First‐trimester chorionic bump‐‐Association with fetal aneuploidy in a high‐risk population

Abstract

Agreement in identifying chorionic bumps is near-perfect. A sonographically nonisolated chorionic bump is not associated with significant additional aneuploidy risk, whereas a sonographically isolated chorionic bump confers a significantly increased likelihood of aneuploidy in high-risk fetuses. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45:3-7, 2017.

Chorionic bump at 11 to 13 weeks' gestation: Prevalence and clinical significance

“…After the late first‐trimester period, the possibility of fetal demise or pregnancy loss later on in pregnancy decreases dramatically, especially in fetuses with no abnormal findings on scan . The incidental reported association with ectopic pregnancy, fetal malformations such as acrania or forearm reduction defect, and chromosomal abnormalities were also absent from our series, although one of our fetuses had trisomy 21.…”

“…Since the original report describing the sonographic characteristics and prognostic significance of the chorionic bump in 2006, subsequent reports have confirmed its association with a higher rate of pregnancy loss than in pregnancies without a chorionic bump . This is true for the general population as well as for patients with a history of infertility treatment.…”

“…This is true for the general population as well as for patients with a history of infertility treatment. A computerized search of the Pubmed/MEDLINE database using the term “chorionic bump” revealed six larger series describing between eight to 57 cases and eight isolated reports describing one or two cases. Our report adds an additional 23 cases, for a total of 190 cases reported in the English literature.…”

“…Our report adds an additional 23 cases, for a total of 190 cases reported in the English literature. Among them, only one report has included cases detected at 11 to 13 weeks' gestation, stating that “12 of 16 cases were referred for nuchal translucency thickness measurement.” However, this was a retrospective study based on high‐risk pregnancies in which available cytogenetic information was the main entry criterion. Furthermore, specific details of the sonographic and clinical findings in this group of patients were not provided by the authors …”

A bump inside the bump: a case report of a chorionic bump

“…Wax, Cartin, Litton, Pinette, and Lucas performed a retrospective cohort study that included 690 singleton pregnancies between 2010 and 2015, where both ultrasound and chromosomal testing were performed. Since it was not their practice at the time to report the finding of the chorionic bump on the ultrasound report, two examiners who were blinded to all patient information (including chromosomal testing result and pregnancy outcomes) retrospectively reviewed all patients' ultrasound images for the presence or absence of chorionic bumps.…”