First trimester complete blood cell indices in early and late onset preeclampsia

Abstract

Objective: This study aimed to compare the first trimester complete blood count (CBC) indices of pregnancies complicated by early-onset preeclampsia (EOPE) or late-onset preeclampsia (LOPE). Material and Methods: A retrospective case-control study was conducted with 186 patients. Patients were classified into three subgroups: EOPE, LOPE, and control groups. First trimester CBC results were obtained for each patient. Hemoglobin, hematocrit, red blood cell distribution width, mean corpuscular volume, white blood cell (WBC) count, neutrophil, eosinophil, basophil, lymphocyte, monocyte, mean platelet volume, platelet distribution width, plateletcrit, and platelet count were compared. The neutrophil lymphocyte ratio was calculated by dividing the absolute lymphocyte count by the absolute neutrophil count. The platelet lymphocyte ratio was calculated by dividing the absolute lymphocyte count by the absolute platelet count. Results: The total number of cases was 21, 42, and 123, in the EOPE, LOPE, and control groups, respectively. There were statistically significant differences in the total WBC and neutrophil counts between the three groups (both p<0.05). WBC and neutrophil counts were found to be highest in the EOPE group, and the LOPE group had higher levels compared with controls. The optimal cut-off values to predict EOPE for WBC and neutrophil counts were 9.55×10 3 / μL (sensitivity 71.4% and specificity 70.7%) and 6.45×10 3 /μL (sensitivity 66.7% and specificity 74.8%), respectively. Conclusion: Increased first trimester WBC and neutrophil counts may be predictive for EOPE.

A cut‐off value for systemic immune‐inflammation index in the prediction of adverse neonatal outcomes in preterm premature rupture of the membranes

“…The efficacy of evaluating maternal complete blood count parameters and indices for the prediction of adverse obstetric outcomes were investigated in many studies. [13][14][15][16] Inflammation-related complications like preeclampsia, preterm delivery, placentation anomalies and intrahepatic cholestasis of pregnancy are the leading subjects of these investigations. [13][14][15][16] However, to the best of our knowledge, no study in the literature evaluated the performance of SII in the prediction of adverse obstetric outcomes.…”

“…[13][14][15][16] Inflammation-related complications like preeclampsia, preterm delivery, placentation anomalies and intrahepatic cholestasis of pregnancy are the leading subjects of these investigations. [13][14][15][16] However, to the best of our knowledge, no study in the literature evaluated the performance of SII in the prediction of adverse obstetric outcomes. On the other hand, SII has been widely used in the field of oncology with promising results and it has become to be used in the other branches of medicine as a prognostic factor.…”

“…[9][10][11][12] Moreover, cost-effective, practical and noninvasive estimation of inflammation based on maternal complete blood count parameters has become popular in recent years, especially in the field of obstetrics. [13][14][15][16] Neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), mean platelet volume (MPV) and red blood cell distribution width (RDW) are the most commonly used parameters in the literature. [13][14][15][16] However, each parameter has its own advantages along with its limitations.…”

“…[13][14][15][16] Neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), mean platelet volume (MPV) and red blood cell distribution width (RDW) are the most commonly used parameters in the literature. [13][14][15][16] However, each parameter has its own advantages along with its limitations. Therefore, mentioned parameters are generally used in combinations and interpretation of the results may be confusing for the physicians.…”

“…Therefore, mentioned parameters are generally used in combinations and interpretation of the results may be confusing for the physicians. [13][14][15][16] Thus, a novel index named Systemic Immune-Inflammation Index (SII)(neutrophil × platelet /lymphocyte) was developed based on peripheral lymphocyte, neutrophil and platelet counts in 2014. 17 Although mostly used in the field of oncology, SII has come to be preferred by other fields of medicine in recent years.…”