First‐trimester crown–rump length and embryonic volume of aneuploid fetuses measured in virtual reality

Baken, Leonie; Heesch, P. N. A. C. M. van; Wildschut, H. I. J.; Koning, Anton H. J.; Spek, Peter J. van der; Steegers, Eric A.P.; Exalto, N.

doi:10.1002/uog.12365

Cited by 20 publications

(14 citation statements)

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“…Furthermore, we performed automatic EV measurement on the same datasets with high success rates. A retrospective study recently showed that EV represents a more effective measurement of first‐trimester growth restriction in aneuploidy fetuses compared with CRL, since all three dimensions are taken into account instead of only one dimension. We minimized confounding of gestational age by including women with strict pregnancy dating only, based on a known LMP, regular cycle and concordant CRL.…”

Section: Discussionmentioning

confidence: 99%

Periconceptional maternal ‘high fish and olive oil, low meat’ dietary pattern is associated with increased embryonic growth: The Rotterdam Periconceptional Cohort (Predict) Study

Parisi

Rousian

Huijgen

et al. 2017

Ultrasound in Obstet & Gyne

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Section: Discussionmentioning

confidence: 99%

Periconceptional maternal ‘high fish and olive oil, low meat’ dietary pattern is associated with increased embryonic growth: The Rotterdam Periconceptional Cohort (Predict) Study

Parisi

Rousian

Huijgen

et al. 2017

Ultrasound in Obstet & Gyne

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“…It is not surprising that embryonic growth is related to fetal growth in the second and third trimester of pregnancy and to newborn birthweight (Mook-Kanamori et al 2010;van Uitert et al 2013b). Moreover, when an embryo is relatively small, it has an increased risk of complications during pregnancy, such as fetal chromosomal abnormalities, miscarriage, low birthweight, fetal growth restriction and prematurity (Smith et al 1998;Bukowski et al 2007;Mook-Kanamori et al 2010;Salomon et al 2011;Abuelghar et al 2013;Baken et al 2013;van Uitert et al 2013avan Uitert et al , 2013b. In future, it would be interesting to see whether not only embryonic size, but also embryonic developmental stages are affected by environmental exposures.…”

Section: Dogma Of Uniform Embryonic Growthmentioning

confidence: 99%

Embryonic health: new insights, mHealth and personalised patient care

Steegers‐Theunissen

Steegers

2015

Reprod. Fertil. Dev.

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The worldwide epidemic of non-communicable diseases (NCD), including obesity, is a burden to which poor lifestyles contribute significantly. Events in early life may enhance susceptibility to NCD, with transmission into succeeding generations. This may also explain, in part, why interventions in adulthood are less effective to reduce NCD risk. New insights reveal that the early embryo, in particular, is extremely sensitive to signals from gametes, trophoblastic tissue and periconception maternal lifestyles. Embryonic size and growth as determinants of embryonic health seem to impact future health. A relatively small embryo for gestational age is associated with pregnancy complications, as well as with the risk of early features of NCD in childhood. Although personal lifestyles are modifiable, they are extremely difficult to change. Therefore, adopting a life course approach from the periconception period onwards and integrated into patient care with short-term reproductive health benefits may have important implications for future prevention of NCD. The current reproductive population is used to Internet and social media. Therefore, they can be reached via mobile phone (mHealth) platforms that provide personalised lifestyle (pre)pregnancy programs. This will offer opportunities and possibly great benefits for the health of current and succeeding generations.

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“…Animal experiments have shown that IGF-1and IGF-2 are principally involved in fetal growth and placental development, respectively [ 21 , 22 , 23 ]. Fetuses with ES are known to be small for gestational age in the first trimester [ 24 ], and therefore the expression of IGFBP-1 may be altered. Miell et al [ 25 ] was the first to find that maternal serum levels of IGFBP-1 in ES pregnancies were elevated compared to mothers with normal or DS fetuses.…”

Section: Discussionmentioning

confidence: 99%

Two-Dimensional Differential Gel Electrophoresis to Identify Protein Biomarkers in Amniotic Fluid of Edwards Syndrome (Trisomy 18) Pregnancies

et al. 2016

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BackgroundEdwards syndrome (ES) is a severe chromosomal abnormality with a prevalence of about 0.8 in 10,000 infants born alive. The aims of this study were to identify candidate proteins associated with ES pregnancies from amniotic fluid supernatant (AFS) using proteomics, and to explore the role of biological networks in the pathophysiology of ES.MethodsAFS from six second trimester pregnancies with ES fetuses and six normal cases were included in this study. Fluorescence-based two-dimensional difference gel electrophoresis (2D-DIGE) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) were used for comparative proteomic analysis. The identified proteins were further validated by Western blotting and the role of biological networks was analyzed.ResultsTwelve protein spots were differentially expressed by more than 1.5-fold in the AFS of the ES pregnancies. MALDI-TOF/MS identified one up-regulated protein: apolipoprotein A1 (ApoA1), and four under-regulated proteins: vitamin D binding protein (VDBP), alpha-1-antitrypsin (A1AT), insulin-like growth factor-binding protein 1 (IGFBP-1), and transthyretin (TTR). Western blot and densitometric analysis of ApoA1, A1AT, IGFBP-1, and TTR confirmed the alteration of these proteins in the amniotic fluid samples. Biological network analysis revealed that the proteins of the ES AFS were involved mainly in lipid and hormone metabolism, immune response, and cardiovascular disease.ConclusionsThese five proteins may be involved in the pathogenesis of ES. Further studies are needed to explore.

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First‐trimester crown–rump length and embryonic volume of aneuploid fetuses measured in virtual reality

Cited by 20 publications

References 21 publications

Periconceptional maternal ‘high fish and olive oil, low meat’ dietary pattern is associated with increased embryonic growth: The Rotterdam Periconceptional Cohort (Predict) Study

Periconceptional maternal ‘high fish and olive oil, low meat’ dietary pattern is associated with increased embryonic growth: The Rotterdam Periconceptional Cohort (Predict) Study

Embryonic health: new insights, mHealth and personalised patient care

Two-Dimensional Differential Gel Electrophoresis to Identify Protein Biomarkers in Amniotic Fluid of Edwards Syndrome (Trisomy 18) Pregnancies

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