First trimester neutrophil-to-lymphocyte ratio (NLR) and pregnancy outcomes in medically assisted reproduction (MAR): a case control study

Siristatidis, Charalambos; Christoforaki, Viktoria; Mastorakos, George; Vrantza, Tereza

doi:10.1080/09513590.2018.1534949

Cited by 6 publications

(5 citation statements)

References 36 publications

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“…Higher cytokine levels, such as mononuclear cells secreted from TNF-a, IFN-g, TNF-b, and IL-2 and increased inflammatory response, were detected in RPL patients when compared with normal pregnancy [8,9]. Incremental neutrophil and leukocyte counts were reported from the first trimester to the third trimester in non-complicated pregnancy cases, and conversely, decremental lymphocyte counts were identified from the first trimester to the second trimester [10]. Therefore, the NLR was investigated as a predictive marker for pathologic gestational events [11,12,13,14,15].…”

Section: Resultsmentioning

confidence: 90%

Could Fibrinogen to Albumin Ratio be a Predictive Marker for Recurrent Pregnancy Loss

Cimsir¹,

Yildiz²

2021

Preprint

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Aims: Recurrent pregnancy loss (RPL) is usually defined by two or more consecutive clinical miscarriages, which causes psychological trauma for couples. In this study, we aimed to investigate the predictive role of Fibrinogen to albumin ratio (FAR) in patients with RPL. Methods: Pregnant women in their first trimester of pregnancy were included in the study and divided in to two groups as RPL patients (n:44) and patients with no previous recurrent miscarriage (n:60) as control group. Demographical parameters and routine blood parameters (fibrinogen, D-dimer, fibrinogen to albumin ratio (FAR), neutrophil to lymphocyte ratio (NLR), platelet count, main platelet volume (MPV), and red cell distribution width (RDW) values) were compared between the RPL group and the control group. Results: The groups were determined to be statistically different in regards to gravidity and parity (p<0.05). The difference between the groups was statistically different in regards to fibrinogen (mg/dl), albumin (g/dl), FAR (%), NLR (%), RDW-coefficient of variation (CV) (%), RDW-standard deviation (SD) (fL), and platelet counts (10-3/ uL). However, MPV (fL) and D-dimer (ug/L) levels were similar in both groups. The receiver operating characteristic (ROC) curve analysis revealed that the NLR levels were 84.1% sensitive and 75% specific with a cut-off value of 4.27 and the FAR levels were 79.5% sensitive and 88.3% specific with a cut-off value of 105.69 for predicting RPL. Conclusion: Our results indicate that the FAR and NLR levels seem to be effective parameters for predicting RPL with high sensitivity and specificity.

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Section: Resultsmentioning

confidence: 90%

Could Fibrinogen to Albumin Ratio be a Predictive Marker for Recurrent Pregnancy Loss

Cimsir¹,

Yildiz²

2021

Preprint

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“…This underscores the potential utility of NLR as a prognostic indicator for IVF outcomes. However, it is essential to acknowledge that previous studies have presented divergent data regarding the predictive efficacy of NLR in delineating IVF outcomes [9, 10, 20]. Our study was the first to achieve a robust independent predictive ability for NLR in identifying IVF outcomes, potentially owing to our relatively larger sample size and more precise sample selection.…”

Section: Discussionmentioning

confidence: 91%

Predicting the Outcomes of In Vitro Fertilization Using Baseline Maternal Serum Inflammatory Markers: A Retrospective Cohort Study

Hantoushzadeh,

Poorabdoli,

Parsaei

et al. 2024

American J Rep Immunol

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ProblemAchieving pregnancy through in vitro fertilization (IVF) remains a challenge, with less than one‐third of women succeeding. There is a pressing need for reliable predictive tools to assess the likelihood of post‐IVF pregnancy. While some serum inflammatory biomarkers have been investigated for their predictive potential, substantial knowledge gaps persist. This study examined the utility of different inflammatory markers in predicting IVF outcomes.Method of StudyInflammatory markers including the white blood cell count, neutrophil‐to‐lymphocyte ratio (NLR), platelet count, mean platelet volume, platelet distribution width, platelet‐to‐lymphocyte ratio (PLR), C‐reactive protein (CRP), erythrocyte sedimentation rate, and vitamin D3 were assessed. Study outcomes were chemical pregnancy (positive serum beta‐human chorionic gonadotropin 2 weeks post‐embryo transfer), clinical pregnancy (detection of pregnancy sac via transvaginal ultrasonography), and viable pregnancy (detection of fetal heart rate). Univariate and multivariate logistic regression analyses were conducted, with multivariate analysis incorporating age, body mass index, infertility duration, type, and etiology, as well as all studied serum inflammatory markers, embryo count, stage, quality, and endometrial thickness.ResultsLower NLR (p < 0.001, odds ratio [OR] = 0.372 [0.247–0.559]) and CRP (p = 0.035, odds ratio = 0.956 [0.916–0.997]) predicted chemical pregnancy in univariate analysis, with NLR maintaining significance in multivariate analysis (p = 0.022, OR = 0.319 [0.120–0.848]). Lower NLR (p < 0.001, OR = 0.309 [0.198–0.482]) and PLR (p = 0.013, OR = 0.994 [0.990–0.999]) predicted clinical pregnancy, with NLR surviving multivariate analysis (p = 0.005, OR = 0.217 [0.075–0.626]). Lower NLR (p < 0.001, OR = 0.320 [0.198–0.516]) also predicted viable pregnancy, maintaining statistical significance in multivariate analysis (p = 0.002, OR = 0.177 [0.058–0.541]). Other studied inflammatory markers did not predict IVF outcomes.ConclusionsNLR emerged as a robust independent predictor of pregnancy attainment after IVF.

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“…Previous studies have also investigated whether hematological parameters investigated in the first trimester can predict poor obstetric outcomes [13][14][15][16]. First trimester a platelet cut-off value of ≥240,500 (62% sensitivity and 73.6% specificity) best predicted the subsequent development of IO.…”

Section: Discussionmentioning

confidence: 99%

Can systemic immune inflammation index measured in the first trimester predict later occurring isolated oligohydramnios?

Dinç¹,

Naykı²

2023

Med-Science

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The aim of our study is to determine whether the first trimester systemic immune inflammation index (SII) and other hematological markers can be useful as new markers of isolated oligohydramnios that may develop later. Two main groups were formed in this retrospective study. In the first group, 57 pregnant women with isolated oligohydramnios in their third trimester (between 28-40 weeks) were included. The control group consisted of 137 healthy pregnant women with a normal amniotic index (AFI) in the third trimester. First trimester and delivery hemogram values and newborn results of all pregnant women in both groups included in the study were noted for statistical comparison. Platelet (261.895+8.04), which is the hematological marker that best predicts IO in the first trimester, was found to be higher than the healthy group (244.390±4.79) (p=0.03). PLR was the best predictor of oligohydramnios in the third trimester. The PLR level was determined as 113,288, and the cut-off value was 64.91%, the upper limit was 95% CI, the specificity was 51.09%, the positive predictive value was 35.58%, and the negative predictive value was 77.78%. The platelet count in the first trimester and the progressive increase in the number of PLR in the third trimester are significantly related in the prediction of oligohydromnus. SII, NLR and PLR measured in the first trimester are useless in predicting isolated oligohydramnios that may develop in the future.

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First trimester neutrophil-to-lymphocyte ratio (NLR) and pregnancy outcomes in medically assisted reproduction (MAR): a case control study

Cited by 6 publications

References 36 publications

Could Fibrinogen to Albumin Ratio be a Predictive Marker for Recurrent Pregnancy Loss

Could Fibrinogen to Albumin Ratio be a Predictive Marker for Recurrent Pregnancy Loss

Predicting the Outcomes of In Vitro Fertilization Using Baseline Maternal Serum Inflammatory Markers: A Retrospective Cohort Study

Can systemic immune inflammation index measured in the first trimester predict later occurring isolated oligohydramnios?

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