First trimester prediction of small‐ and large‐for‐gestation neonates by an integrated model incorporating ultrasound parameters, biochemical indices and maternal characteristics

Abstract

Prediction for birthweight deviations is feasible using data available at the routine 11-14 weeks' examination. Delta CRL and delta nuchal translucency were significant independent predictors for both SGA and LGA.

Elevated placental growth factor concentrations at 11–14weeks of gestation to predict gestational diabetes mellitus

“…Variance inflation factor for co-linearity assessment and White's test for heteroscedasticity were used. We adjusted first trimester ultrasound parameters for CRL according to previous published first trimester nomogramms [27]. Thus we converted NT and FHR to d-NT and d-FHR respectively.…”

Fetal volume at 11–14 gestational weeks: reference ranges and association with first trimester biochemical and biophysical markers

“…The fact that FV captures more efficiently fetal growth in the first trimester could be important as recent studies support a potential link between early fetal growth deviations, assessed by CRL, with pregnancy complications, such as preterm birth, low birth weight, or small for gestational age [5,13,14]. We have previously reported that birth weight deviations are predictable by using an integrated model incorporating the delta-CRL value and ultrasound parameters, biochemical indices, and maternal characteristics [14].…”

“…The same analysis was repeated for mean Ut-PI. We used previous published formulas to calculate delta values for nuchal translucency (d-NT) and fetal heart rate (d-FHR) [14,25]. Delta values were computed by subtracting the expected value from the observed.…”

Cribado precoz de diabetes gestacional y macrosomía

“…Sin embargo, en fetos macrosómicos, la TN en el primer trimestre era mayor que en fetos con peso adecuado para la edad gestacional [71][72][73]75,76 .…”

“…Los modelos de predicción de macrosomía incluyen factores de la historia clínica materna, como edad, peso, talla, raza, antecedente de feto macrosómico, tabaquismo, diabetes mellitus e hipertensión crónica, marcadores biofísicos como la TN y el IP medio de arterias uterinas, y marcadores bioquímicos como la PAPP-A y la b-hCG libre en sangre materna, obteniendo tasas de detección alrededor de un 35 y un 20% para tasas de falsos positivos del 10 y el 5%, respectivamente 33,[71][72][73]76 .…”