First trimester serum concentrations of placental proteins in singleton and multiple IVF pregnancies: implications for Down syndrome screening

Background Down's syndrome occurs when a person has three copies of chromosome 21-or the specific area of chromosome 21 implicated in causing Down's syndrome-rather than two. It is the commonest congenital cause of mental retardation. Noninvasive screening based on biochemical analysis of maternal serum or urine, or fetal ultrasound measurements, allows estimates of the risk of a pregnancy being a ected and provides information to guide decisions about definitive testing. Objectives To estimate and compare the accuracy of second trimester serum markers for the detection of Down's syndrome.

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Second trimester serum tests for Down's Syndrome screening

Alldred

Deeks

Guo

et al. 2012

Cochrane Database of Systematic Reviews

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First trimester serum tests for Down's syndrome screening

Alldred

Takwoingi

Guo

et al. 2015

Cochrane Database of Systematic Reviews

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Tests involving two markers in combination with maternal age, specifically PAPP-A, free βhCG and maternal age are significantly better than those involving single markers with and without age. They detect seven out of 10 Down's affected pregnancies for a fixed 5% FPR. The addition of further markers (triple tests) has not been shown to be statistically superior; the studies included are small with limited power to detect a difference.The screening blood tests themselves have no adverse effects for the woman, over and above the risks of a routine blood test. However some women who have a 'high risk' screening test result, and are given amniocentesis or chorionic villus sampling (CVS) have a risk of miscarrying a baby unaffected by Down's. Parents will need to weigh up this risk when deciding whether or not to have an amniocentesis or CVS following a 'high risk' screening test result.

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Urine tests for Down's syndrome screening

Alldred

Guo

Takwoingi

et al. 2015

Cochrane Database of Systematic Reviews

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First trimester serum concentrations of placental proteins in singleton and multiple IVF pregnancies: implications for Down syndrome screening

Cited by 6 publications

References 29 publications

Second trimester serum tests for Down's Syndrome screening

Second trimester serum tests for Down's Syndrome screening

First trimester serum tests for Down's syndrome screening

Urine tests for Down's syndrome screening

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