First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies

Yamada, Takashi; Morikawa, Mamoru; Yamada, Takahiro; Kishi, Reiko; Sengoku, Kazuo; Endo, Toshiaki; Saito, Tsuyoshi; Cho, Kazutoshi; Minakami, Hisanori

doi:10.1007/s00404-012-2501-5

Cited by 18 publications

(13 citation statements)

References 33 publications

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“…In nonpregnant adults, exposure to smoking is negatively associated with folate and (Yamada et al, ) vitamin B12 levels and positively associated with homocysteine levels (Mannino, Mulinare, Ford, & Schwartz, ; O'Callaghan, Meleady, Fitzgerald, & Graham, ). A number of studies have examined this association in pregnant women, but a complete overview of published literature is currently not available (Bakker, Timmermans, Steegers, Hofman, & Jaddoe, ; Bergen et al, ; Nilsen et al, ; Relton, Pearce, & Parker, ; Yamada et al, ). Therefore, we aimed to systematically review the literature evaluating the associations of exposure to smoking during pregnancy with levels of folate, vitamin B12, and homocysteine in maternal and cord blood.…”

Section: Introductionmentioning

confidence: 99%

Folate, vitamin B12, and homocysteine in smoking‐exposed pregnant women: A systematic review

Tuenter

Bautista-Niño

Vitezova

et al. 2018

Maternal & Child Nutrition

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Smoking exposure is associated with pregnancy complications, as are levels of folate, vitamin B12, and homocysteine. In nonpregnant adults, smoking exposure is associated negatively with folate and vitamin B12 levels and positively with homocysteine levels. A complete overview of the literature on this topic in pregnant women is lacking. To evaluate evidence of associations of maternal smoking exposure during pregnancy and levels of folate, homocysteine, and vitamin B12 in pregnancy and in cord blood, we searched MEDLINE, Embase, CINAHL, Cochrane, Scopus, Web of Science, and reference lists of relevant studies until August 2017. We selected studies in pregnant women describing the association of passive or active smoking and levels of folate, homocysteine, and/or vitamin B12. Data were extracted by two independent reviewers. We included 32 studies of 2,015 identified references with a total of 37,822 participants and more than 6,000 smokers. Twenty-eight studies measured folate, 14 measured vitamin B12, and 13 measured homocysteine. Nineteen out of 28 studies assessing folate reported significantly lower levels in pregnant women exposed to smoking compared with those unexposed. Vitamin B12 levels were lower in smoking mothers in eight out of 14 studies. Homocysteine levels tended to be higher in mothers exposed to smoking. Smoking exposure during pregnancy is generally associated with lower folate and vitamin B12 levels and higher homocysteine levels. This may help raise further awareness about the consequences of smoking and the need to encourage stopping smoking in all, especially in pregnant women.

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Section: Introductionmentioning

confidence: 99%

Folate, vitamin B12, and homocysteine in smoking‐exposed pregnant women: A systematic review

Tuenter

Bautista-Niño

Vitezova

et al. 2018

Maternal & Child Nutrition

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“…Observational studies have suggested that a higher level of folate in pregnancy is associated with higher birth weight, increased placental weight and fewer preterm births [28,55-57], although these results have not been confirmed in other populations recently [58]. At present the association between folate insufficiency and the onset of placenta-mediated diseases, such as spontaneous abortion [58-65], preterm birth [66-75], foetal growth retardation [76-80], pre-eclampsia [81-88], abruptio placentae [89] and stillbirth [90] is still not entirely clear.…”

Section: Introductionmentioning

confidence: 99%

“…At present the association between folate insufficiency and the onset of placenta-mediated diseases, such as spontaneous abortion [58-65], preterm birth [66-75], foetal growth retardation [76-80], pre-eclampsia [81-88], abruptio placentae [89] and stillbirth [90] is still not entirely clear.…”

Section: Introductionmentioning

confidence: 99%

Prevention of congenital malformations and other adverse pregnancy outcomes with 4.0 mg of folic acid: community-based randomized clinical trial in Italy and the Netherlands

Bortolus

Blom

Filippini

et al. 2014

BMC Pregnancy Childbirth

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BackgroundIn 2010 a Cochrane review confirmed that folic acid (FA) supplementation prevents the first- and second-time occurrence of neural tube defects (NTDs). At present some evidence from observational studies supports the hypothesis that FA supplementation can reduce the risk of all congenital malformations (CMs) or the risk of a specific and selected group of them, namely cardiac defects and oral clefts. Furthermore, the effects on the prevention of prematurity, foetal growth retardation and pre-eclampsia are unclear.Although the most common recommendation is to take 0.4 mg/day, the problem of the most appropriate dose of FA is still open.The aim of this project is to assess the effect a higher dose of peri-conceptional FA supplementation on reducing the occurrence of all CMs. Other aims include the promotion of pre-conceptional counselling, comparing rates of selected CMs, miscarriage, pre-eclampsia, preterm birth, small for gestational age, abruptio placentae.Methods/DesignThis project is a joint effort by research groups in Italy and the Netherlands. Women of childbearing age, who intend to become pregnant within 12 months are eligible for the studies. Women are randomly assigned to receive 4 mg of FA (treatment in study) or 0.4 mg of FA (referent treatment) daily. Information on pregnancy outcomes are derived from women-and-physician information.We foresee to analyze the data considering all the adverse outcomes of pregnancy taken together in a global end point (e.g.: CMs, miscarriage, pre-eclampsia, preterm birth, small for gestational age). A total of about 1,000 pregnancies need to be evaluated to detect an absolute reduction of the frequency of 8%. Since the sample size needed for studying outcomes separately is large, this project also promotes an international prospective meta-analysis.DiscussionThe rationale of these randomized clinical trials (RCTs) is the hypothesis that a higher intake of FA is related to a higher risk reduction of NTDs, other CMs and other adverse pregnancy outcomes. Our hope is that these trials will act as catalysers, and lead to other large RCTs studying the effects of this supplementation on CMs and other infant and maternal outcomes.Trial registrationItalian trial: ClinicalTrials.gov Identifier: NCT01244347.Dutch trial: Dutch Trial Register ID: NTR3161.

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“…24,25 In addition, 5-MTHF was observed to be an equally effective alternative to folic acid in decreasing total homocysteine concentrations(tHcy)in women. 15 Daily use of 400 μg folic acid per day has been recommended by public health authorities worldwide before and during early week of gestation to reduce the risk of NTDs. 4,5 Despite proven efficacy, the use of iron and folic acid (IFA) supplements during pregnancy is low with only 38% of women reporting regular intake during their last pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Folic Acid; Is Simple Folic Acid Effective to Replenish RBC Folate Stores Among Pakistani Femal Epatients? Small Case.

Yasmin

2017

TPMJ

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ABSTRACT… Objectives: The objective of our study was to assess the effectiveness of folic acid in optimizing the red blood cells folate levels and to observe the frequency of folate resistance among Pakistani female patients. Setting: Outpatient Department of Obstetrics & Gynaecology, Jinnah Post graduate Medical Centre (JPMC), Karachi. Period: January-July 2016. Methodology: Participants fulfilling the inclusion criteria were included after informed consent. Detail history and physical examination was done in each participant. All study participants received 5mg (400 µg) folic acid as a daily supplement for 24 weeks. Red blood cell folate concentrations were measured at baseline and after 24 weeks of therapy. Paired sample t-test was used to find out significant difference between folate levels. Results: A total of 44 women (23 pregnant while 21 non pregnant) were included in the study. Mean age of the participants was 27.6 ± 5.9years and mean BMI was 23.9 ± 4.1kg/m 2 respectively. The mean values of Red blood cells folate at baseline and at 24 weeks were 623.6 ± 406.6 and 861.9 ± 432.4respectively. Paired sample t-test results showed that there was no significant difference. Thirty-two (70.4%) women showed an increase in RBC folate status while 13 (29.6%) women had steady or decreased levels of folate after taking folic acid for 24 weekswhich may be due to RBS enzyme methylenetetrahydrofolate reductase (MTHFR) deficiency. Conclusion: Simple folic acid supplementation is not very helpful in improving folate status in female Pakistani patients. Resistant to improvement may be due to MTHFR deficiency in our study subjects. Key words:Folic

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First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies

Cited by 18 publications

References 33 publications

Folate, vitamin B12, and homocysteine in smoking‐exposed pregnant women: A systematic review

Folate, vitamin B12, and homocysteine in smoking‐exposed pregnant women: A systematic review

Prevention of congenital malformations and other adverse pregnancy outcomes with 4.0 mg of folic acid: community-based randomized clinical trial in Italy and the Netherlands

Folic Acid; Is Simple Folic Acid Effective to Replenish RBC Folate Stores Among Pakistani Femal Epatients? Small Case.

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