First trimester trophoblast and placental bed vascular volume measurements in IVF or IVF/ICSI pregnancies

Rifouna, Maria S.; Reus, A.; Koning, Anton H. J.; Spek, Peter J. van der; Exalto, N.; Steegers, Eric A.P.; Laven, Joop S.E.

doi:10.1093/humrep/deu273

Cited by 26 publications

(21 citation statements)

References 28 publications

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“…(30) As these diseases of placental alterations have been shown to have detectably smaller placental volumes on first trimester ultrasound, only one small study investigated whether there is a difference in placental volume in IVF conceptions compared to spontaneous conceptions, finding no difference, but it was limited to sample size. (17) We also did not find a difference in placental size based on volume and chorionic villi obtained at CVS comparing pregnancies from couples with infertility to spontaneous conceptions nor did we find differences among the fertility treatments (NIFT versus IVF). Our study was significantly larger and was adequately powered to detect a clinically significant difference in EPV that has been associated with fetal growth restriction, an outcome noted in gestations conceived with fertility treatments.…”

Section: Discussionmentioning

confidence: 55%

“…(12–16) Thus, placental volume may be a marker of placental insufficiency in early gestation. To date, there has only been one small study comparing 1 st trimester placental volume based on mode of conception and while these authors found no differences in 10 week placental volumes between 84 pregnancies conceived spontaneously compared to 70 pregnancies conceived by IVF, this was largely limited by small sample size (17). In addition, these investigators did not address NIFT conceptions which are also associated with increased risk of pregnancy related complications (6)…”

Section: Introductionmentioning

confidence: 99%

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Mode of conception does not appear to affect placental volume in the first trimester

Churchill

Wang

Goldstein

et al. 2017

Fertility and Sterility

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Objective To study whether infertility treatments, including IVF and non-IVF fertility treatments (NIFT), are associated with diseases of placental insufficiency in early gestation. First trimester placental volumes by ultrasound and chorionic villi weight during sampling (CVS) were performed to detect differences between pregnancies conceived spontaneously versus with fertility treatments. Design Retrospective cohort Setting Academic tertiary center Patients Women with singleton pregnancies undergoing CVS and first trimester ultrasound from 4–2007 to 11–2015. Interventions Estimated placental volume (EPV) was calculated from ultrasound images using a validated computation and CVS estimated tissue weight was performed using a validated visual analog scale. Main Outcomes Measured Adjusted linear regression was used to compare EPV and CVS weight based on mode of conception. Results 1977 spontaneous, 334 conceived with fertility treatments (133 NIFT, and 201 IVF) were included. Significant differences in maternal age, gravidity, hypertension and smoking status were identified. EPV and CVS weight were correlated with maternal age, gestational age, and maternal hypertension. Adjusted linear regression showed no difference in EPV in pregnancies conceived with fertility treatments versus spontaneously. CVS weight was significantly lower in the IVF conceptions in unadjusted univariate analyses. However, following adjusted regression, this was no longer significant. Conclusions Mode of conception does not appear to affect first trimester placental size. As differences in maternal age, hypertension and smoking status differ among the groups and are correlated to placental size, it may be the underlying patient population leading to abnormal placentation and insufficiency, not the fertility treatments utilized.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Mode of conception does not appear to affect placental volume in the first trimester

Churchill

Wang

Goldstein

et al. 2017

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

“…Recently, Rifouna et al analyzed 70 IVF pregnancies and found no difference with respect to control pregnancies in placental vascular volume at 12 weeks and trophoblastic volume at 10 weeks of gestation. The difference in the technique used to evaluate the placenta and the difference in the characteristics of IVF pregnancies (oocyte donation occurred only in two cases) and in the sample size analyzed (70 vs 416 in the present study) may explain the differences observed.…”

Section: Discussionmentioning

confidence: 99%

Placental volume and uterine artery Doppler evaluation at 11 + 0 to 13 + 6 weeks' gestation in pregnancies conceived with in‐vitro fertilization: comparison between autologous and donor oocyte recipients

Rizzo

Aiello

Pietrolucci

et al. 2016

Ultrasound in Obstet & Gyne

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“…Other studies have also suggested that IVF pregnancies have an increased risk of placenta previa and placenta abruption (27), as well as a higher incidence of marginal cord insertion and abnormal placental shapes (28). Small studies on first trimester trophoblast and placental bed vascular volume as an indicator of normal placentation did not show a difference between IVF and spontaneous conceptions (29). Frozen embryo transfers may create an environment more prone to abnormal placentation, which in turn translates to the higher risk of biochemical pregnancy and pregnancy loss observed in this study.…”

Section: Discussionmentioning

confidence: 88%

Abnormal implantation after fresh and frozen in vitro fertilization cycles

Wang

Kathiresan

Bresee

et al. 2017

Fertility and Sterility

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Objective To determine whether fresh embryo transfers are at a higher risk of abnormal implantation compared to frozen embryo transfers while accounting for the embryo stage at transfer. Design Retrospective cohort study. Patients We used data from the Society for Assisted Reproductive Technologies (SART) to identify all fresh and frozen autologous IVF cycles from 2004–2013 resulting in a positive pregnancy test. The cycles were parameterized into a four-level predictor of 1) fresh blastocyst transfer, 2) fresh non-blastocyst transfer, 3) frozen blastocyst transfer, and 4) frozen non-blastocyst transfer. Intervention None. Main Outcome Measure We examined a composite outcome of abnormal implantation, defined as biochemical pregnancy, ectopic/heterotopic pregnancy, and first trimester pregnancy loss. Regression modeling was performed with repeated measures multivariable logistic regression, adjusted for age, parity, number of embryos transferred, infertility diagnosis, and calendar year of treatment. Results Of 509,938 cycles analyzed, 31.8% resulted in abnormal implantation. Compared to a fresh blastocyst transfer, a fresh non-blastocyst transfer had a 22% increase risk of abnormal implantation, a frozen blastocyst transfer had a 36% increase risk, and a frozen non-blastocyst transfer had a 57% increase risk. When individual outcomes were analyzed, fresh embryo transfers had a lower risk of biochemical pregnancy and pregnancy loss, but a higher risk for ectopic/heterotopic pregnancy. Conclusion Fresh blastocyst transfers had the lowest overall risk of abnormal implantation, but a higher risk of ectopic/heterotopic pregnancy. Although embryo cryopreservation is indicated in certain treatment cycles, elective embryo cryopreservation may not be the optimal strategy to adopt for all cycles.

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First trimester trophoblast and placental bed vascular volume measurements in IVF or IVF/ICSI pregnancies

Abstract: This study was financially supported by the Erasmus Trustfonds, the Meindert de Hoop foundation and the Fonds NutsOhra. No competing interests are declared.

Cited by 26 publications

References 28 publications

Mode of conception does not appear to affect placental volume in the first trimester

Mode of conception does not appear to affect placental volume in the first trimester

Placental volume and uterine artery Doppler evaluation at 11 + 0 to 13 + 6 weeks' gestation in pregnancies conceived with in‐vitro fertilization: comparison between autologous and donor oocyte recipients

Abnormal implantation after fresh and frozen in vitro fertilization cycles

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