FIRST-TRIMESTER URINE FREE BETA hCG, BETA CORE, AND TOTAL OESTRIOL IN PREGNANCIES AFFECTED BY DOWN'S SYNDROME: IMPLICATIONS FOR FIRST-TRIMESTER SCREENING WITH NUCHAL TRANSLUCENCY AND SERUM FREE BETA hCG

Spencer, Kevin; Noble, P. L.; Snijders, R. J. M.; Nicolaides, Kypros H.

doi:10.1002/(sici)1097-0223(199706)17:6<525::aid-pd105>3.0.co;2-i

Cited by 37 publications

(14 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the data indicate that in 45,X pregnancies maternal serum PAPP-A is signi®cantly reduced. In contrast to a previous study of eight affected pregnancies, where maternal serum free b-hCG was increased (Spencer et al, 1997), in this larger study free b-hCG was not signi®cantly different from normal. In pregnancies with other sex chromosomal defects maternal serum PAPP-A and free b-hCG were not signi®cantly different from normal.…”

Section: Discussioncontrasting

confidence: 99%

Maternal serum free ?-hCG and PAPP-A in fetal sex chromosome defects in the first trimester

Spencer¹,

Tul²,

Nicolaides³

2000

Prenat. Diagn.

104

View full text Add to dashboard Cite

We have studied maternal serum free beta-hCG and PAPP-A, and fetal nuchal translucency (NT) in a series of 46 cases of fetal Turner's syndrome, 13 cases of other sex chromosomal anomalies and compared these with 947 control pregnancies in the first trimester. In cases of Turner's syndrome (45,X) the median fetal NT was significantly higher than in controls (4.76 MoM), the median PAPP-A was significantly lower (0.49 MoM), whilst the free beta-hCG was not significantly different (1.11 MoM). For NT, 93% (43/46) of cases were equal to or greater than the 95th centile of controls, for PAPP-A 35% (16/46) of cases were less than or equal to the 5th centile of controls and for free beta-hCG 15% (7/46) of cases were equal to or greater than the 95th centile of controls. For other sex chromosomal anomalies (47XXX, XXY, XYY) the median NT was increased (2.07 MoM) whilst PAPP-A was not significantly decreased (0.88 MoM) and free beta-hCG was not significantly different (1.07 MoM) from controls. Using a previously derived multivariate risk algorithm for trisomy 21, incorporating NT, PAPP-A, free beta-hCG and maternal age, 96% of the Turner's cases and 62% of the other sex chromosomal anomalies would have been identified.

show abstract

Section: Discussioncontrasting

confidence: 99%

Maternal serum free ?-hCG and PAPP-A in fetal sex chromosome defects in the first trimester

Spencer¹,

Tul²,

Nicolaides³

2000

Prenat. Diagn.

104

View full text Add to dashboard Cite

show abstract

“…In addition, the only first-trimester sample in the Cuckle et al (1995) study had a MoM of 1·01. Spencer et al (1997), however, demonstrated a median Down syndrome MoM of 2·91 in 22 first-trimester samples. The median MoM in five first-trimester Down syndrome samples in the present study was 2·89, similar to results observed by Spencer et al (1997).…”

Section: Discussionmentioning

confidence: 93%

“…Spencer et al (1997), however, demonstrated a median Down syndrome MoM of 2·91 in 22 first-trimester samples. The median MoM in five first-trimester Down syndrome samples in the present study was 2·89, similar to results observed by Spencer et al (1997). Larger data sets are needed to better assess the degree of elevation of beta-core (hCG) in the first trimester.…”

Section: Discussionmentioning

confidence: 93%

Comparison of urinary free beta (hCG) and beta-core (hCG) in prenatal screening for chromosomal abnormalities

Hallahan¹,

Krantz²,

Tului³

et al. 1998

Prenat. Diagn.

View full text Add to dashboard Cite

“…Although an increase is also seen in the first trimester the clinical results are less encouraging (Cuckle et al, 1996;Korman et al, 1997;Macintosh et al, 1997;Spencer et al, 1997).…”

Section: Introductionmentioning

confidence: 97%

Measures of urine concentration in maternal urine screening for Down syndrome

et al. 1998

View full text Add to dashboard Cite

A study was carried out to assess eight methods of normalizing the level of urinary β‐core human chorionic gonadotropin (hCG) for variable urine concentration. We compared the standard approach—creatinine determination by the Jaffe method—with high performance liquid chromatography (HPLC) measurement of creatinine, osmolarity and optical density at five wavelengths. Urine samples were included from a total of 472 women with unaffected singleton pregnancies at 15 weeks' gestation. The median β‐core hCG value was determined for each decile group when the results were ranked in turn according to the different measures of urine concentration. Creatinine using the Jaffe method had a much stronger relationship with median β‐core hCG than the other measures. Linear regression across the decile groups gave an R2 value for Jaffe of 0·85 compared with HPLC of 0·53, osmolarity of 0·52, optical density at 405nm of 0·72, at 450nm of 0·57, at 490nm of 0·33, at 570nm of 0·34 and at 630nm of 0·33. We conclude that when screening with urinary β‐core hCG measuring creatinine appears to be an adequate method of allowing for variable urine concentration. Copyright © 1998 John Wiley & Sons, Ltd.

show abstract

FIRST-TRIMESTER URINE FREE BETA hCG, BETA CORE, AND TOTAL OESTRIOL IN PREGNANCIES AFFECTED BY DOWN'S SYNDROME: IMPLICATIONS FOR FIRST-TRIMESTER SCREENING WITH NUCHAL TRANSLUCENCY AND SERUM FREE BETA hCG

Cited by 37 publications

References 30 publications

Maternal serum free ?-hCG and PAPP-A in fetal sex chromosome defects in the first trimester

Maternal serum free ?-hCG and PAPP-A in fetal sex chromosome defects in the first trimester

Comparison of urinary free beta (hCG) and beta-core (hCG) in prenatal screening for chromosomal abnormalities

Measures of urine concentration in maternal urine screening for Down syndrome

Contact Info

Product

Resources

About