First use of creatine hydrochloride in premanifest Huntington disease

Tuckfield, Chris

doi:10.5694/mja14.01070

Cited by 3 publications

(1 citation statement)

References 154 publications

(207 reference statements)

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“…They found that creatine pyruvate, which has around eight-fold higher aqueous solubility than CM, had a significant (approximately 25%) increase in oral bioavailability compared to the latter [ 38 ]. In addition to providing further evidence of less than complete oral bioavailability for CM, such findings suggest that creatine salts with improved aqueous solubility and oral absorption characteristics could provide improvements over CM in therapeutic applications requiring high doses of creatine [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth

et al. 2018

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Creatine is an ergogenic compound used by athletes to enhance performance. Supplementation with creatine monohydrate (CM) has been suggested for musculoskeletal and neurological disorders. Until now, little is known about its pharmacokinetic profile. Our objective was to determine the oral bioavailability of CM and the influence of dose on oral absorption. Rats were dosed orally with low dose (10 mg/kg) or high dose (70 mg/kg) 13C-labeled CM. Blood samples were removed at various time points. Muscle and brain tissue were collected at the conclusion of the study. Plasma and tissue levels of 13C-labeled creatine were determined using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Physiologically based pharmacokinetic (PBPK) models of CM were built using GastroPlus™. These models were used to predict the plasma concentration–time profiles of creatine hydrochloride (CHCL), which has improved aqueous solubility compared to CM. Absolute oral bioavailability for low dose CM was 53% while high dose CM was only 16%. The simulated Cmax of 70 mg/kg CHCL was around 35 μg/mL compared to 14 μg/mL for CM with a predicted oral bioavailability of 66% with CHCL compared to 17% with CM. Our results suggest that the oral bioavailability of CM is less than complete and subject to dose and that further examination of improved dosage formulations of creatine is warranted.

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Section: Discussionmentioning

confidence: 99%

Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth

et al. 2018

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Creatine hydrochloride or creatine monohydrate plus resistance training: which combination has a greater effect on oxidative stress, muscle damage, performance, and body composition in soldiers?

Eghbali,

Riahy,

Arazi

2024

Sport Sci Health

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Supplementing With Which Form of Creatine (Hydrochloride or Monohydrate) Alongside Resistance Training Can Have More Impacts on Anabolic/Catabolic Hormones, Strength and Body Composition?

Eghbali,

Arazi,

Suzuki

2024

Physiol Res

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The purpose of this study was to determine the effects of resistance training (RT) alongside creatine-hydrochloride (Cr-HCl) or creatine monohydrate (CrM) supplementation on anabolic/catabolic hormones, strength, and body composition. Forty participants with an age range of 18-25 years were randomly divided into four groups (n=10): RT+Cr-HCl (0.03 g.kg-1 of body mass), RT+CrM-loading phase (CrM-LP) (0.3 g.kg-1 of body mass for five days (loading) and 0.03 g.kg-1 body mass for 51 days (maintenance)), RT+CrM-without loading phase (CrM-WLP) (0.03 g.kg-1 body mass), and RT+placebo (PL). The participants consumed supplements and performed RT with an intensity of 70-85 % 1RM for eight weeks. Before and after the training and supplementation period, strength (1RM), body composition (percent body fat (PBF), skeletal muscle mass (SMM), muscular cross-sectional area (MCSA)) and serum levels of testosterone, growth hormone (GH), insulin-like growth factor-1 (IGF-1), cortisol, adrenocorticotropic hormone (ACTH), follistatin and myostatin were measured. The results showed that in the supplementation groups, strength, arm and thigh MCSA, and SMM significantly increased, and PBF significantly decreased (P≤0.05); this change was significant compared to the PL group (P≤0.05). In addition, the results showed a significant increase in GH, IGF-1 levels, the ratio of follistatin/myostatin, testosterone/cortisol (P≤0.05), and a significant decrease in cortisol and ACTH levels (P≤0.05) in the supplementation groups. Hormonal changes in GH, IGF-1, testosterone/cortisol, cortisol, and ACTH levels in the supplementation groups were significant compared to the PL group (P≤0.05). The results showed that CrM and Cr-HCl significantly enhanced the beneficial effects of RT on strength, hypertrophy, and hormonal responses, with Cr-HCl showing no benefit over CrM.

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First use of creatine hydrochloride in premanifest Huntington disease

Cited by 3 publications

References 154 publications

Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth

Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth

Creatine hydrochloride or creatine monohydrate plus resistance training: which combination has a greater effect on oxidative stress, muscle damage, performance, and body composition in soldiers?

Supplementing With Which Form of Creatine (Hydrochloride or Monohydrate) Alongside Resistance Training Can Have More Impacts on Anabolic/Catabolic Hormones, Strength and Body Composition?

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