First Year of Life: Prenatal Craniofacial Development

Sperber, G.H.

doi:10.1597/1545-1569(1992)029<0109:fyolpc>2.3.co;2

Cited by 36 publications

(27 citation statements)

References 7 publications

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“…This is plausible from a developmental perspective, considering the intimate relationship of face and brain development in both normal and pathologic conditions [43,64]. Support for this hypothesis is also garnered by recent studies from our laboratory demonstrating abnormal brain structure associated with ICLP in adult males [51][52][53][54].…”

Section: Introductionmentioning

confidence: 71%

Social function in boys with cleft lip and palate: Relationship to ventral frontal cortex morphology

Boes

Murko

Wood

et al. 2007

Behavioural Brain Research

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Isolated clefts of the lip and/or palate (ICLP) are developmental craniofacial abnormalities that have consistently been linked to increased social inhibition or shyness. Two explanations have been proposed: 1) psychosocial factors related to differences in facial appearance may lead to low selfconcept and subsequent shyness, or 2) abnormal development of brain structures involved in social function, such as the ventral frontal cortex (VFC), may underlie the difference. To investigate these two possibilities this study was designed to evaluate measures of social function in relation to measures of self-concept and VFC morphology. Subjects included 30 boys (age 7-12) with ICLP and a comparison group of 43 boys without cleft in the same age category. Social function and selfconcept were assessed using questionnaires with standardized scoring filled out by subjects and one of their parents. The cortical volume and surface area of the VFC, composed of the orbitofrontal cortex (OFC) and straight gyrus (SG), were evaluated using structural magnetic resonance imaging. The ICLP subjects had significantly impaired social function relative to the comparison group. No difference in self-concept was identified. VFC morphology revealed significant differences between groups, particularly decreased volume and surface area in the left SG of the ICLP group. Moreover, abnormal VFC measures were correlated with social dysfunction but measures of self-concept were

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Section: Introductionmentioning

confidence: 71%

Social function in boys with cleft lip and palate: Relationship to ventral frontal cortex morphology

Boes

Murko

Wood

et al. 2007

Behavioural Brain Research

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“…Attempts to determine the ossification of the Meckel's cartilage were also made by using enzymatic and histochemical methods. Studies conducted by Sperber (1992) showed no activity of acid phosphatase in the chondrocytes of the Meckel's cartilage-a step considered to be necessary during the ossification process. Histochemical studies of Granstrom et al (1988) demonstrated that the Meckel's cartilage showed intense activity with lactate dehydrogenase and dihydronicotinamide adenine dinucleotide (NADH 2 )-diaphorase, and weak activity with acid phosphatase.…”

Section: Discussionmentioning

confidence: 97%

“…It is known that, in the late fetal period (between the 16th and the 30th weeks), the central portion of the Meckel's cartilage regresses (Sperber 1992). The caudal part of the Meckel's cartilage extends to the developing ear, giving rise to the ossicles such as the malleus and the incus via endochondral ossification (Frommer and Margolies 1970;Bhaskar et al 1953;Diewert 1983;GoretNicaise and Pilet 1983).…”

Section: Discussionmentioning

confidence: 99%

The Meckel’s cartilage in human embryonic and early fetal periods

Wyganowska‐Świątkowska

Przystańska

2010

Anat Sci Int

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The Meckel's cartilage itself and the mandible are derived from the first branchial arch, and their development depends upon the contribution of the cranial neural crest cells. The prenatal development of the Meckel's cartilage, along with its relationship to the developing mandible and the related structures, were studied histologically in human embryos and fetuses. The material was obtained from a collection of the Department of Anatomy, and laboratory procedures were used to prepare sections, which were stained according to standard light-microscopy methods. The formation of the Meckel's cartilage and its related structures was observed and documented. Some critical moments in the development of the Meckel's cartilage are suggested. The sequential development of the Meckel's cartilage started as early as stage 13 (32 days) with the appearance of condensation of mesenchymal cells within the mandibular prominence. During stage 17 (41 days), the primary ossification center of the mandible appeared on the inferior margin of the Meckel's cartilage. The muscular attachments to the Meckel's cartilage in embryos were observed at stage 18 (44 days). Their subsequent movement into the developing mandible during the 10th week seemed to diminish the role of the Meckel's cartilage as the supportive core; simultaneously, the process of regression within the cartilage was induced. During the embryonic period, the bilateral Meckel's cartilages were in closest contact at the posterior surface of their superior margins, preceding formation of the symphyseal cartilage at this site. The event sequence in the development of the Meckel's cartilage is finally discussed.

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“…12 También, se ha asociado la hipodoncia con gran cantidad de síndromes craneofaciales dentro de los que están la secuencia de Pierre Robin (69%), síndrome de Van der Woude (70%), diferentes formas de displasia ectodérmica y otros síndromes craneofaciales relacionados con hendiduras labiopalatinas. 16 La alta frecuencia de hipodoncia en pacientes con labio y paladar sugiere la relación entre los mecanismos de formación de fisuras orales y los procesos de odontogénesis. Los dos procesos dependen de la gobernabilidad de la migración de las células de la cresta neural y de las interacciones epitelio mesén-quima.…”

Section: Discussionunclassified

“…El 35% de las madres presentó antecedente de fumadora y el 43% acostumbraba a tomar alcohol. Se encontró que las mujeres en embarazo que habían consumido alcohol tenían una probabilidad 1,5 veces de tener un hijo/a con labio y/o paladar hendido aunque este valor no fue estadísticamente significativo [OR 1,5 IC 95% 0,[13][14][15][16][17]66]. Conclusiones: al determinar la asociación entre el consumo de cigarrillo y alcohol como factor de riesgo en labio y paladar hendido, no se encontró una relación estadísticamente significativa, pero sí una relación positiva entre las variables mencionadas.…”

Section: Introductionunclassified

Asociación Entre El Consumo De Cigarrillo Y Alcohol en La Gestante Como Factor De Riesgo Para Labio Y/O Paladar Hendido No Sindrómico

2012

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RESUMENObjetivo: determinar la asociación entre el consumo de cigarrillo y alcohol en la mujer embarazada como factor de riesgo para labio y/o paladar hendido no sindrómico e hipodoncia. Materiales y métodos: se realizó un estudio de corte trasversal con una muestra de 79 pacientes entre los 4 y 18 años que habían sido diagnosticados con labio y/o paladar hendido no sindrómico. Se realizó una encuesta a las madres, se diligenció el formulario del Estudio Colaborativo Latinoamericano de Malformaciones Congénitas (ECLAM) y se tomó una radiografía panorámica a los pacientes. Se realizó un análisis descriptivo, se usó la prueba de Chi 2 y Test exacto de Fisher para las variables cualitativas y t de Student o U. de Mann Whitney para las cuantitativas. Una regresión logística determinó la asociación entre las variables consumo de cigarrillo y alcohol con la presencia de labio y/o paladar hendido no sindrómico. Se consideró un valor alpha igual a 0,05. Resultados: el 96% de la población estudiada presentó labio y/o paladar hendido, relacionándose con el lado en que el paciente tenía la hipodoncia, que se presentó en el 85% de la muestra. En los pacientes con labio y paladar hendido se encontró hipodoncia en el 85% de los casos, la hipodoncia del incisivo lateral superior es la más frecuente en el 81% de los casos, seguido de la hipodoncia de premolares, en el 7% de los casos. El 35% de las madres presentó antecedente de fumadora y el 43% acostumbraba a tomar alcohol. Se encontró que las mujeres en embarazo que habían consumido alcohol tenían una probabilidad 1,5 veces de tener un hijo/a con labio y/o paladar hendido aunque este valor no fue estadísticamente significativo [OR 1,5 IC 95% 0,[13][14][15][16][17]66]. Conclusiones: al determinar la asociación entre el consumo de cigarrillo y alcohol como factor de riesgo en labio y paladar hendido, no se encontró una relación estadísticamente significativa, pero sí una relación positiva entre las variables mencionadas. [Torres EA, Gómez G, Pinzón Z. Asociación entre el consumo de cigarrillo y alcohol en la gestante como factor de riesgo para labio y/o paladar hendido no sindrómico. Ustasalud 2012; 11: 88 -94] Palabras clave: Labio leporino, Hábito de fumar, Anodoncia ASSOCIATION BETWEEN CIGARETTE AND ALCOHOL CONSUMPTION IN PREGNANT AS A RISK FACTOR FOR NON-SYNDROMIC CLEFT LIP AND/OR PALATE ABSTRACTObjective: to assess the association between cigarette smoking and alcohol consumption in pregnant women as a risk factor for cleft lip and / or non-syndromic cleft palate and hypodontia. Methods: a cross-sectional study was done with a sample of 79 patients between 4 and 18 years who had been diagnosed with nonsyndromic cleft lip and/or cleft palate. We conducted a survey of mothers, the form from Latin American Collaborative Study of Congenital Malformations (ECLAM) was filled out and a panoramic x-ray was taken for every patient. We performed a descriptive analysis, we used the Chi 2 test and Fisher exact test for qualitative variables and Student t test or U. Mann Whitney test ...

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First Year of Life: Prenatal Craniofacial Development

Cited by 36 publications

References 7 publications

Social function in boys with cleft lip and palate: Relationship to ventral frontal cortex morphology

Social function in boys with cleft lip and palate: Relationship to ventral frontal cortex morphology

The Meckel’s cartilage in human embryonic and early fetal periods

Asociación Entre El Consumo De Cigarrillo Y Alcohol en La Gestante Como Factor De Riesgo Para Labio Y/O Paladar Hendido No Sindrómico

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