Firstborn microcrystallization method to prepare nanocapsules containing artesunate

Xiao, Xincai; Hong, Zongguo

doi:10.2147/ijn.s10907

Cited by 9 publications

(5 citation statements)

References 14 publications

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“…Due to the regulation of pH and the addition of electrolytes, gelatin was preferentially coacervation to the nanocrystal surface based on the high surface energy of the Cur nanocrystals. After formaldehyde crosslinking, the coacervated gelatin formed a closed core-shell structure [ 50 ]. In order to improve the targeting properties, chondroitin sulfate was used to modify the Cur-TGNCs.…”

Section: Discussionmentioning

confidence: 99%

Chondroitin sulfate-modified tragacanth gum–gelatin composite nanocapsules loaded with curcumin nanocrystals for the treatment of arthritis

Sun,

Du,

Liu

et al. 2024

J Nanobiotechnol

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Rheumatoid arthritis (RA) is a chronic autoimmune disease of yet undetermined etiology that is accompanied by significant oxidative stress, inflammatory responses, and damage to joint tissues. In this study, we designed chondroitin sulfate (CS)-modified tragacanth gum–gelatin composite nanocapsules (CS-Cur-TGNCs) loaded with curcumin nanocrystals (Cur-NCs), which rely on the ability of CS to target CD44 to accumulate drugs in inflamed joints. Cur was encapsulated in the form of nanocrystals into tragacanth gum–gelatin composite nanocapsules (TGNCs) by using an inborn microcrystallization method, which produced CS-Cur-TGNCs with a particle size of approximately 80 ± 11.54 nm and a drug loading capacity of 54.18 ± 5.17%. In an in vitro drug release assay, CS-Cur-TGNCs showed MMP-2-responsive properties. During the treatment of RA, CS-Cur-TGNCs significantly inhibited oxidative stress, promoted the polarization of M2-type macrophages to M1-type macrophages, and decreased the expression of inflammatory factors (TNF-α, IL-1β, and IL-6). In addition, it also exerted excellent anti-inflammatory effects, and significantly alleviated the swelling of joints during the treatment of gouty arthritis (GA). Therefore, CS-Cur-TGNCs, as a novel drug delivery system, could lead to new ideas for clinical therapeutic regimens for RA and GA. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Chondroitin sulfate-modified tragacanth gum–gelatin composite nanocapsules loaded with curcumin nanocrystals for the treatment of arthritis

Sun,

Du,

Liu

et al. 2024

J Nanobiotechnol

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“…The cytotoxicity effect of formulation on L1210 and MCF7 cell lines was decreased compared to the free drug [ 63 ]. Xiao et al prepared nanocapsules containing artesunate by microcrystallization method with a potential to increase the bioavailability of artesunate [ 64 ]. Encapsulation of artemisinin and its derivatives onto nanocapsules resulted in improved drug stability, prolonged drug release mechanism and enhanced bioavailability [ 61 , 62 , 63 , 64 ].…”

Section: Delivery Systems Loaded With Artemisinin and Its Derivatimentioning

confidence: 99%

“…Xiao et al prepared nanocapsules containing artesunate by microcrystallization method with a potential to increase the bioavailability of artesunate [ 64 ]. Encapsulation of artemisinin and its derivatives onto nanocapsules resulted in improved drug stability, prolonged drug release mechanism and enhanced bioavailability [ 61 , 62 , 63 , 64 ]. The drug linker used influenced the release mechanism of artemisinin from the nanocapsules [ 63 ].…”

Section: Delivery Systems Loaded With Artemisinin and Its Derivatimentioning

confidence: 99%

Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives

Aderibigbe

2017

Molecules

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Artemisinin and its derivatives have been reported to be experimentally effective for the treatment of highly aggressive cancers without developing drug resistance, they are useful for the treatment of malaria, other protozoal infections and they exhibit antiviral activity. However, they are limited pharmacologically by their poor bioavailability, short half-life in vivo, poor water solubility and long term usage results in toxicity. They are also expensive for the treatment of malaria when compared to other antimalarials. In order to enhance their therapeutic efficacy, they are incorporated onto different drug delivery systems, thus yielding improved biological outcomes. This review article is focused on the currently synthesized derivatives of artemisinin and different delivery systems used for the incorporation of artemisinin and its derivatives.

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“…Especially in recent years, nanocarriers including nanospheres or nanocapsules have been hot issues on their design, characterization and fabrication because of their small size being able to traverse the smallest capillaries in the body, higher specific surface area [4], and multifunction. In the biomedical field [5][6][7][8], because of improving the stability and bioavailability of hydrophobic drugs, the nanocarriers have significance on science and technology research.…”

Section: Introductionmentioning

confidence: 99%

Nanofabrication method of amphiphilic spheres using linear hydrophobic polymer chains as templates

Yan¹,

Wang²,

Guan³

et al. 2019

Preprint

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Investigation about nanocarriers has been a hot issue and nanofabrication method still plays an important role. In this work, a phenomenon that reacting linear polystyrene chains can collapse when a reaction media changed from tetrahydrofuran to water was utilized as templates to prepare nanospheres. Free radicals on the surface of the collapsed templates can initiate hydrophilic monomers N-isopropylacrylamide and N,N’-methylenebisacrylamide in water. Effect levels of some factors including stirring rate, N-isopropylacrylamide concentration and reaction time of styrene on size and monodispersity of the spheres were investigated. The results show the obtained spheres had polystyrene cores and crosslinked poly(N-isopropylacrylamide) shells. Monodispersed nanospheres with mean diameter 63nm can be obtained under optimized condition. The results also display that the first effect factor was the reaction time of styrene, and the second was the stirring rate. The proposed technology provides a mode to prepare monodisperse nanospheres or nanocapsules, which are highly attractive for targeting hydrophobic-drug delivery systems, oil-water separation, single molecule detect, colloid science and so on.

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Firstborn microcrystallization method to prepare nanocapsules containing artesunate

Cited by 9 publications

References 14 publications

Chondroitin sulfate-modified tragacanth gum–gelatin composite nanocapsules loaded with curcumin nanocrystals for the treatment of arthritis

Chondroitin sulfate-modified tragacanth gum–gelatin composite nanocapsules loaded with curcumin nanocrystals for the treatment of arthritis

Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives

Nanofabrication method of amphiphilic spheres using linear hydrophobic polymer chains as templates

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