Fischer et al. reply

Fischer, Julia; Koch, Linda; Emmerling, Christian; Vierkotten, Jeanette; Peters, Thomas; Rüther, Ulrich

doi:10.1038/nature08808

Cited by 32 publications

(40 citation statements)

References 10 publications

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“…In protostellar systems, model grids, such as the one discussed here, are most accurate and useful when multiwavelength data are available to provide as many constraints as possible (see e.g. Fischer et al 2010). Nonetheless, PACS and SPIRE sample the peak of the protostar's SED and we expect Herschel data alone to provide a relatively good estimate of the envelope properties in particular.…”

Section: Synthetic Photometrymentioning

confidence: 99%

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Predicted colors and flux densities of protostars in theHerschelPACS and SPIRE filters

Ali¹,

Tobin

Fischer

et al. 2010

A&A

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Upcoming surveys with the Herschel Space Observatory will yield far-IR photometry of large samples of young stellar objects, which will require careful interpretation. We investigate the color and luminosity diagnostics based on Herschel broad-band filters to identify and discern the properties of low-mass protostars. We compute a grid of 2016 protostars in various physical congurations, present the expected flux densities and flux density ratios for this grid of protostars, and compare Herschel observations of three protostars to the model results. These provide useful constraints on the range of colors and fluxes of protostar in the Herschel filters. We find that Herschel data alone is likely a useful diagnostic of the envelope properties of young stars.

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Section: Synthetic Photometrymentioning

confidence: 99%

“…The HOPS program (Fischer et al 2010) imaged 4 protostars in Orion L 1641 region for which PACS 70 and 160 μm photometry is available for 3 sources. These stars are shown with the diamond symbol in Fig.…”

Section: The Hops Protostars Samplementioning

confidence: 99%

Predicted colors and flux densities of protostars in theHerschelPACS and SPIRE filters

Ali¹,

Tobin

Fischer

et al. 2010

A&A

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“…The last years' studies, including the full genomic analysis demonstrated the essential connection between obesity and rs9939609 single nucleotide polymorphism in the first intron of FTO fat gene, fat mass and obesity associated [17,18]. But mechanisms of this gene influence still insufficiently studied.…”

Section: Discussion Of Research Resultsmentioning

confidence: 99%

Detection of Rs9939609 Polymorphism of Fto Gene and Rs324011 Polymorphism of Stat6 Gene and Severity Degree of Bronchial Asthma Associated With Obesity

Федів

Mеlnik

2017

EUREKA: Health Sciences

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The aim of this research was to analyze the distribution of FTO and STAT6 genes polymorphism in patients with bronchial asthma (BA), associated with obesity (Ob) depending on the main disease severity degree. Materials and methods. The study included 117 patients 18–48 years old, divided in 3 groups. The main group (bronchial asthma, associated with obesity) included 57 patients, two groups of comparison – 30 patients with the diagnosis BA and a normal body weight, and 30 patients with obesity, but without the pathology of the bronchopulmonary system. The general genomic DNA was extracted from blood according to the standard protocol. The genetic typing was realized by the method of allele-specific amplification with the detection of results in the real time regime using TaqMan-probes, complementary to polymorphic parts of DNA. The detection of deletions in FTO and STAT 6 genes was realized by the method of polymerase chain reaction (PCR) using specific primers. Results. In the main group, among patients with BA and Ob, carriers of Т/Т genotype were 36,84 %, Т/А – 45,61 %, А/А – 17,55 % against 40 %, 60 % and 0 % respectively in PHP group by FTO gene. Carriers of С/С genotype in the main group were 38,6 %, С/Т – 35,09 %, Т/Т – 26,31 % against 40 %, 55 % and 5 % respectively in PHP group by STAT6 gene. In the main group the light persisting BA was diagnosed in 20,0 % of cases, middle severity – in 60,0 % and severe – in 20,0 % of patients. In the group of comparison this disease severity was observed in 17,7 %, 66,5 % and 15,8 % of observations, respectively. Conclusions. So, among patients with BA, associated with Ob with the middle and severe course of asthma the percent of heterozygous (Т/А) and mutant carriers (А/А) rs9939609 polymorphism of FTO gene is higher than at the light course. The analogous situation is observed at the study of rs324011 polymorphism of STAT6 (C2892T) gene among this category of patients. So, the determination of FTO and STAT6 genes polymorphism in patients with BA, associated with Ob, can be considered as a marker of the more severe course of asthma.

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“…The properties of ClC-Ka/barttin and ClC-Kb/barttin tabulated are those observed in mammalian expression systems: in oocytes the channels display time-and voltage-dependent gating. The rodent homologue (ClC-K1) of ClC-Ka demonstrates limited expression as a homomer, but its function is enhanced by barttin which increases both channel opening probablility in the physiological range of potentials [27,32,88] reviewed in [29]). ClC-Ka is approximately 5 to 6-fold more sensitive to block by 3-phenyl-CPP and DIDS than ClC-Kb, while newly synthesized benzofuran derivatives showed the same blocking affinity ( 10 M) on both CLC-K isoforms [50].…”

Section: Overviewmentioning

confidence: 99%

The Concise Guide to PHARMACOLOGY 2015/16: Other ion channels

Alexander

Kelly

Marrion

et al. 2015

British J Pharmacology

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The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/ 10.1111/bph.13351/full. Other ion channels are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed version of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and GRAC and provides a permanent, citable, point-in-time record that will survive database updates. Conflict of interestThe authors state that there are no conflicts of interest to declare.

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Fischer et al. reply

Cited by 32 publications

References 10 publications

Predicted colors and flux densities of protostars in theHerschelPACS and SPIRE filters

Predicted colors and flux densities of protostars in theHerschelPACS and SPIRE filters

Detection of Rs9939609 Polymorphism of Fto Gene and Rs324011 Polymorphism of Stat6 Gene and Severity Degree of Bronchial Asthma Associated With Obesity

The Concise Guide to PHARMACOLOGY 2015/16: Other ion channels

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