Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential

Kashyap, Dharambir; Garg, Vivek Kumar; Tuli, Hardeep Singh; Yerer, Mükerrem Betül; Sak, Katrin; Sharma, Anil Kumar; Kumar, Manoj; Aggarwal, Vaishali; Sandhu, Sardul Singh

doi:10.3390/biom9050174

Cited by 201 publications

(126 citation statements)

References 184 publications

(191 reference statements)

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“…Although numerous reports have described the proapoptotic effects of flavonoids and thus their possible use in cancer prevention [ 142 , 143 ], several flavonoids have also been shown to have potent antiapoptotic activity and protect cells against damage caused by various stimuli, both in vitro and in vivo in animal disease models. The involved mechanisms include the inhibition of the intrinsic apoptotic pathway by the preservation of mitochondrial function (i.e., maintaining mΔΨ), regulation of redox potential and MOMP by downregulation of BAX and BAK or upregulation of BCL-2 and BCL-xL [ 144 ].…”

Section: Flavonoids In Mitochondrial Pathwaysmentioning

confidence: 99%

Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?

Kicińska

Jarmuszkiewicz

2020

Molecules

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A large number of diverse mechanisms that lead to cytoprotection have been described to date. Perhaps, not surprisingly, the role of mitochondria in these phenomena is notable. In addition to being metabolic centers, due to their role in cell catabolism, ATP synthesis, and biosynthesis these organelles are triggers and/or end-effectors of a large number of signaling pathways. Their role in the regulation of the intrinsic apoptotic pathway, calcium homeostasis, and reactive oxygen species signaling is well documented. In this review, we aim to characterize the prospects of influencing cytoprotective mitochondrial signaling routes by natural substances of plant origin, namely, flavonoids (e.g., flavanones, flavones, flavonols, flavan-3-ols, anthocyanidins, and isoflavones). Flavonoids are a family of widely distributed plant secondary metabolites known for their beneficial effects on human health and are widely applied in traditional medicine. Their pharmacological characteristics include antioxidative, anticarcinogenic, anti-inflammatory, antibacterial, and antidiabetic properties. Here, we focus on presenting mitochondria-mediated cytoprotection against various insults. Thus, the role of flavonoids as antioxidants and modulators of antioxidant cellular response, apoptosis, mitochondrial biogenesis, autophagy, and fission and fusion is reported. Finally, an emerging field of flavonoid-mediated changes in the activity of mitochondrial ion channels and their role in cytoprotection is outlined.

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Section: Flavonoids In Mitochondrial Pathwaysmentioning

confidence: 99%

Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?

Kicińska

Jarmuszkiewicz

2020

Molecules

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“…Along with protecting cells from oxidative stress, flavonoids can promote apoptosis and genotoxicity of tumor cells through pro-oxidant activities [ 14 , 15 ]. In addition to the pro-oxidative action and the initiation of apoptosis, other anti-tumorigenic mechanisms of QU action include inhibition of glycolysis and enzyme synthesis, interaction with estrogen type II binding sites, and modulation of numerous molecular targets [ 16 , 17 , 18 ]. The antitumor activity of QU has been investigated in different types of cancers including breast, colon, gastric, leukemia, melanoma, head and neck, and bladder cells [ 13 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Interactions between Cisplatin and Quercetin at Physiological and Hyperthermic Conditions on Cancer Cells In Vitro and In Vivo

et al. 2020

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Quercetin (QU), a hyperthermic sensitizer, when combined with cisplatin (CP) affects tumor growth. To determine the effects of QU and CP and their interactions, multimodal treatment in vitro and in vivo models under physiological and hyperthermic conditions was performed. In vitro, different sensitivity of T24 and UMUC human bladder cancer cells was observed after short-term exposure to QU (2 h) and CP (1 h). Effects of both compounds were investigated at low and high micromolar concentrations (1 and 50 µM, respectively) under both thermal conditions. QU acted in additive or synergistic manner in combination with CP between physiological condition and hyperthermia. As determined by 3-(4,5-dimethylthiazol2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, short-term application of QU and CP reduced cell viability. Clonal assay also indicated that combined treatment with QU and CP is lethal to bladder cancer cells in both conditions. In vivo, CP (5 or 10 mg kg−1) and QU (50 mg kg−1) acted synergistically with hyperthermia (43 °C) and inhibited tumor growth, activated immune effectors and increased mice survival. Our results demonstrate that combined treatment with CP and QU may increase death of tumor cells in physiological and hyperthermic conditions which could be clinically relevant in locoregional chemotherapy.

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“…Quercetin is one of the most prevalent plant flavonoids contained in many fruits and vegetables. Within the flavonoid family, quercetin is the most potent scavenger of ROS [ 33 , 34 ]. Previous studies reported that quercetin could ameliorate pulmonary fibrosis, renal fibrosis, liver fibrosis [ 35 – 37 ].…”

Section: Discussionmentioning

confidence: 99%

Quercetin reduces tendon adhesion in rat through suppression of oxidative stress

Liang

Zhang

et al. 2020

BMC Musculoskelet Disord

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Background Tendon adhesion is one of the most common clinical problems, which poses a considerable challenge to orthopedics doctors. Quercetin (QUE) as a popular drug at present, it has various biological functions, including anti-inflammatory, anti-ischemic, anti-peroxidation, and antioxidant. The purpose of this study was to investigate the effect of quercetin on tendon adhesion and whether quercetin can inhibit oxidative stress. Method Thirty-six rats were randomly divided into three groups, including control group, low QUE (50 mg/kg/day) group, and high QUE (100 mg/kg/day) group. After 1 week, the levels of SOD, MDA and GPx were measured. The degree of tendon adhesion was assessed by macroscopic evaluation and histological evaluation. After 4 weeks. Besides, the pharmacological toxicity of quercetin to main organs were evaluated by histological analysis. Results The extent of superoxide dismutase (SOD) and glutathione peroxidase (GPx) of tendon tissue in high QUE group was significantly higher than those of low QUE group and control group. And the extent of malondialdehyde (MDA) of tendon tissue in high QUE group was significantly lower than that of low QUE group and control group. By macroscopic evaluation and histological analysis, the extent of tendon adhesion in high QUE group was lower than low QUE group and control group. However, there were no significant changes of the major organs through histological analysis. Conclusions Quercetin may be a good and safe strategy in preventing tendon adhesion. But further clinical research is needed before its recommendation in the prevention and treatment of tendon adhesion.

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Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential

Cited by 201 publications

References 184 publications

Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?

Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?

Interactions between Cisplatin and Quercetin at Physiological and Hyperthermic Conditions on Cancer Cells In Vitro and In Vivo

Quercetin reduces tendon adhesion in rat through suppression of oxidative stress

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