Fish and Polyunsaturated Fatty Acid Intake and Carotid Intima–Media Thickness in Japan: the Aidai Cohort Study in Yawatahama, Uchiko, Seiyo, and Ainan

Miyake, Yoshihiro; Tanaka, Keiko; Nagata, Chisato; Senba, Hidenori; Hasebe, Yasuko; Miyata, Toyohisa; Hatori, Takashi; Kimura, Eizen; Matsuura, Bunzo; Kawamoto, Ryuichi

doi:10.5551/jat.63781

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…The AICOS is an ongoing, population-based, prospective study that was started in 2015 (Fukui et al 2019 ; Miyake et al 2020 , 2021 , 2023 ; Hara et al 2020 ; Tanaka et al 2021 ; Nobori et al 2022 ; Kumon et al 2022 ). The baseline survey of the AICOS was conducted in Yawatahama City in 2015, Uchiko Town in 2016, Seiyo City in 2017, and Ainan Town in 2017, with total populations of approximately 36,000, 17,000, 38,000, and 22,000, respectively; these four municipalities are among the 20 municipalities in Ehime Prefecture on Shikoku Island, situated south of Japan’s main island.…”

Section: Methodsmentioning

confidence: 99%

Functional AGXT2 SNP rs180749 variant and depressive symptoms: Baseline data from the Aidai Cohort Study in Japan

Kumon,

Miyake,

Yoshino

et al. 2024

J Neural Transm

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No study has shown the relationship between alanine-glyoxylate aminotransferase 2 (AGXT2) single nucleotide polymorphisms (SNPs) and depressive symptoms. The present case–control study examined this relationship in Japanese adults. Cases and control participants were selected from those who participated in the baseline survey of the Aidai Cohort Study, which is an ongoing cohort study. Cases comprised 280 participants with depressive symptoms based on a Center for Epidemiologic Studies Depression Scale (CES-D) score ≥ 16. Control participants comprised 2034 participants without depressive symptoms based on the CES-D who had not been diagnosed by a physician as having depression or who had not been currently taking medication for depression. Adjustment was made for age, sex, smoking status, alcohol consumption, leisure time physical activity, education, body mass index, hypertension, dyslipidemia, and diabetes mellitus. Compared with the GG genotype of rs180749, both the GA and AA genotypes were significantly positively associated with the risk of depressive symptoms assessed by the CES-D: the adjusted odds ratios for the GA and AA genotypes were 2.83 (95% confidence interval [CI] 1.23–8.24) and 3.10 (95% CI 1.37–8.92), respectively. The TGC haplotype of rs37370, rs180749, and rs16899974 was significantly inversely related to depressive symptoms (crude OR 0.67; 95% CI 0.49–0.90), whereas the TAC haplotype was significantly positively associated with depressive symptoms (crude OR 1.24; 95% CI 1.01–1.52). This is the first study to show significant associations between AGXT2 SNP rs180749, the TGC haplotype, and the TAC haplotype and depressive symptoms.

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Section: Methodsmentioning

confidence: 99%

Functional AGXT2 SNP rs180749 variant and depressive symptoms: Baseline data from the Aidai Cohort Study in Japan

Kumon,

Miyake,

Yoshino

et al. 2024

J Neural Transm

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“…The AICOS is a currently ongoing prospective cohort study designed to clarify risk and protective factors for various health problems that was initiated in 2015 17,18 . The baseline AICOS survey was conducted in Yawatahama City in 2015, Uchiko Town in 2016, and in Seiyo City and Ainan Town in 2017, with total approximate populations of 36000, 17000, 38000, and 22000, respectively.…”

Section: Study Populationmentioning

confidence: 99%

Smoking and secondhand smoke exposure and carotid intima-media thickness: Baseline data from the Aidai Cohort Study in Japan

Saito,

Miyake,

Tanaka

et al. 2024

Tob. Induc. Dis.

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INTRODUCTION Epidemiological evidence regarding the relationship between smoking and secondhand smoke (SHS) exposure and carotid intima-media thickness (CIMT) has been limited in Asian populations. Employing baseline data from the Aidai Cohort Study, Japan, we evaluated the evidence in this cross-sectional study. METHODS Study subjects were 727 men aged 35-88 years and 1297 women aged 34-85 years. Information on smoking, SHS exposure, and confounders was obtained through a self-administered questionnaire. An automated carotid ultrasonography device was used to measure the right and left CIMT. The greatest CIMT measurement in the left or right common carotid artery was considered the maximum CIMT, and a maximum CIMT >1.0 mm was indicative of carotid wall thickening. Age, alcohol consumption, leisure time physical activity, hypertension, dyslipidemia, diabetes mellitus, body mass index, waist circumference, employment, and education level were adjusted at one time. RESULTS The prevalence of carotid wall thickening was 13.0%. The prevalence of never smoking was 30.5% in men and 90.1% in women. Among those who had never smoked, the prevalence of never SHS exposure at home and work was 74.3% and 48.2% in men and 38.3% and 56.3% in women, respectively. Active smoking and pack-years of smoking were independently positively related to carotid wall thickening regardless of sex, although the association with current smoking in women was not significant. Independent positive relationships were shown between former smoking and pack-years of smoking and maximum CIMT in men but not in women. No significant relationships were found between SHS exposure at home and work and carotid wall thickening or maximum CIMT in either men or women. CONCLUSIONS Active smoking, especially pack-years of smoking, was positively associated with carotid wall thickening in both sexes. Such positive associations with maximum CIMT were found only in men; however, interactions between smoking and sex were not significant.

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Fish and Polyunsaturated Fatty Acid Intake and Carotid Intima–Media Thickness in Japan: the Aidai Cohort Study in Yawatahama, Uchiko, Seiyo, and Ainan

Cited by 2 publications

References 29 publications

Functional AGXT2 SNP rs180749 variant and depressive symptoms: Baseline data from the Aidai Cohort Study in Japan

Functional AGXT2 SNP rs180749 variant and depressive symptoms: Baseline data from the Aidai Cohort Study in Japan

Smoking and secondhand smoke exposure and carotid intima-media thickness: Baseline data from the Aidai Cohort Study in Japan

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