Fish c-Jun N-Terminal Kinase (JNK) Pathway Is Involved in Bacterial MDP-Induced Intestinal Inflammation

Qu, Fufa; Xu, Wenqian; Deng, Zhangren; Xie, Yifang; Tang, Jianzhou; Chen, Zhiguo; Luo, Wenjie; Ding, Xiong; Zhao, Dongxin; Fang, Jiamei; Zhou, Zhigang; Liu, Zhen

doi:10.3389/fimmu.2020.00459

Cited by 14 publications

(4 citation statements)

References 46 publications

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“…Inflammatory processes trigger the activation of the p38 and ERK signaling pathways, which have been shown to be critical in IL-6 production [ 33 ]. JNK has a role in the development and function of T cells, as well as the production of proinflammatory cytokines like IL-2, IL-6, and TNF-α [ 34 ]. Additionally, it was indicated that probiotics notably decreased the production of examined proinflammatory cytokines in cell culture, potentially by hindering the activation of the NF-κB and MAPK signaling pathways through TLR4 [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of Paraprobiotic Lactiplantibacillus plantarum KU15122 in LPS-Induced RAW 264.7 Cells

Lee,

Jung,

Lee

et al. 2024

J. Microbiol. Biotechnol.

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Inflammation is a biodefense mechanism that provides protection against painful conditions such as inflammatory bowel disease, other gastrointestinal problems, and irritable bowel syndrome. Paraprobiotics have probiotic characteristics of intestinal modulation along with merits of safety and stability. In this study, heat-killed Lactiplantibacillus plantarum KU15122 (KU15122) was investigated for its anti-inflammatory properties. KU15122 was subjected to heat-killed treatment for enhancement of its safety, and its concentration was set at 8 log CFU/mL for conducting different experiments. Nitric oxide production was most remarkably reduced in the KU15122 group, whereas it was increased in the LPS-treated group. In RAW 264.7 cells, KU15122 inhibited the expression of inducible nitric oxide synthase, cyclooxygenase-2, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α. ELISA revealed that among the tested strains, KU15122 exhibited the most significant reduction in PGE 2 , IL-1β, and IL-6. Moreover, KU15122 inhibited various factors involved in the nuclear factor-kappa B, activator protein-1, and mitogen-activated protein kinase pathways. In addition, KU15122 reduced the generation of reactive oxygen species. The anti-inflammatory effect of KU15122 was likely attributable to the bacterial exopolysaccharides. Conclusively, KU15122 exhibits anti-inflammatory potential against inflammatory diseases.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of Paraprobiotic Lactiplantibacillus plantarum KU15122 in LPS-Induced RAW 264.7 Cells

Lee,

Jung,

Lee

et al. 2024

J. Microbiol. Biotechnol.

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“…NF-κB is just two of the different signaling pathways that TNF uses to carry out its biological actions (JNK). While chronic JNK activation promotes cell death, NF-κB is an anti-apoptotic key cell survival signal ( 86 ). In determining cellular responses to TNF, NF-κB and JNK interact.…”

Section: Serum Cytokine Levels As Possible Immunotherapeutic Targetsmentioning

confidence: 99%

Serum cytokine levels and other associated factors as possible immunotherapeutic targets and prognostic indicators for lung cancer

Zhao

Jia²,

Zhang³

2023

Front. Oncol.

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Lung cancer is one of the most prevalent cancer types and the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) accounts for 80-85% of all cancer incidences. Lung cancer therapy and prognosis largely depend on the disease’s degree at the diagnosis time. Cytokines are soluble polypeptides that contribute to cell-to-cell communication, acting paracrine or autocrine on neighboring or distant cells. Cytokines are essential for developing neoplastic growth, but they are also known to operate as biological inducers following cancer therapy. Early indications are that inflammatory cytokines such as IL-6 and IL-8 play a predictive role in lung cancer. Nevertheless, the biological significance of cytokine levels in lung cancer has not yet been investigated. This review aimed to assess the existing literature on serum cytokine levels and additional factors as potential immunotherapeutic targets and lung cancer prognostic indicators. Changes in serum cytokine levels have been identified as immunological biomarkers for lung cancer and predict the effectiveness of targeted immunotherapy.

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“…MAPK/JNK signaling can be induced by many types of environmental stress and inflammatory responses. Additionally, the stimulators of MAPK-JNK and MAPK-p38 partially overlap, such as TNF-α, IL-1, ultraviolet light, H 2 O 2, and heat shock [ 130 , 131 , 132 ].…”

Section: Signal Transduction Pathwaymentioning

confidence: 99%

Critical Signaling Transduction Pathways and Intestinal Barrier: Implications for Pathophysiology and Therapeutics

Gao,

Cao,

Zhao

et al. 2023

Pharmaceuticals

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The intestinal barrier is a sum of the functions and structures consisting of the intestinal mucosal epithelium, mucus, intestinal flora, secretory immunoglobulins, and digestive juices. It is the first-line defense mechanism that resists nonspecific infections with powerful functions that include physical, endocrine, and immune defenses. Health and physiological homeostasis are greatly dependent on the sturdiness of the intestinal barrier shield, whose dysfunction can contribute to the progression of numerous types of intestinal diseases. Disorders of internal homeostasis may also induce barrier impairment and form vicious cycles during the response to diseases. Therefore, the identification of the underlying mechanisms involved in intestinal barrier function and the development of effective drugs targeting its damage have become popular research topics. Evidence has shown that multiple signaling pathways and corresponding critical molecules are extensively involved in the regulation of the barrier pathophysiological state. Ectopic expression or activation of signaling pathways plays an essential role in the process of shield destruction. Although some drugs, such as molecular or signaling inhibitors, are currently used for the treatment of intestinal diseases, their efficacy cannot meet current medical requirements. In this review, we summarize the current achievements in research on the relationships between the intestinal barrier and signaling pathways. The limitations and future perspectives are also discussed to provide new horizons for targeted therapies for restoring intestinal barrier function that have translational potential.

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Fish c-Jun N-Terminal Kinase (JNK) Pathway Is Involved in Bacterial MDP-Induced Intestinal Inflammation

Cited by 14 publications

References 46 publications

Anti-Inflammatory Effects of Paraprobiotic Lactiplantibacillus plantarum KU15122 in LPS-Induced RAW 264.7 Cells

Anti-Inflammatory Effects of Paraprobiotic Lactiplantibacillus plantarum KU15122 in LPS-Induced RAW 264.7 Cells

Serum cytokine levels and other associated factors as possible immunotherapeutic targets and prognostic indicators for lung cancer

Critical Signaling Transduction Pathways and Intestinal Barrier: Implications for Pathophysiology and Therapeutics

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