Fish consumption and major depression

Hibbeln, Joseph R.

doi:10.1016/s0140-6736(05)79168-6

Cited by 791 publications

(445 citation statements)

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“…In the present study, all subjects were Japanese, whose dietary habits are different from those in Western subjects, particularly in the elderly (Sugano and Hirahara, 2000), and who are reported to have relatively high intakes and high serum levels of omega-3 FAs (more than three times those of Caucasian Americans) (Iso et al, 1989). Hibbeln reported a higher consumption of seafood and a lower prevalence of major depression in Japan than in Western countries (Hibbeln, 1998). The small amount of EPA and DHA, which was hypothesised as one of the mechanisms of causing major depression in previous reports, may have had little contribution towards developing major depression in Japanese populations, who consume large quantities of seafood.…”

Section: Serum Fatty Acid and Depression In Cancer Patients M Kobayakmentioning

confidence: 91%

“…Docosahexaenoic acid (DHA), one of the omega-3 fatty acids (FAs), is a major component of membrane FAs in brain neural cells and lack of DHA has been shown to alter neural transmission in animal studies (Bruinsma and Taren, 2000;Innis, 2000;Ng and Innis, 2003). Previous studies have shown associations between DHA or its precursor, eicosapentaenoic acid (EPA, omega-3 FA), and major depression in subjects without cancer (Edwards et al, 1998;Hibbeln, 1998;Peet et al, 1998;Maes et al, 1999). Other studies have shown their possible therapeutic potential with few adverse effects in clinical trials (Nemets et al, 2002;Peet and Horrobin, 2002;Su et al, 2003).…”

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confidence: 99%

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Levels of omega-3 fatty acid in serum phospholipids and depression in patients with lung cancer

et al. 2005

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Previous studies suggested that omega-3 fatty acids (FAs) have therapeutic effects against depression, but there is no evidence in the oncological setting. Our preliminary study reported the association between lower omega-3 FA intake and occurrence of depression in lung cancer patients. To explore the association further, the present study examined whether depression was associated with lower levels of omega-3 FAs in serum phospholipids. A total of 717 subjects in the Lung Cancer Database Project were divided into three groups by two cutoff points of the Hospital Anxiety and Depression Scale depression subscale (HADS-D). In all, 81 subjects of the nondepression and minor depression groups (HADS-Do5 and 5pHADS-Dp10, respectively) were selected to match with 81 subjects of the major depression group (HADS-D410) for age, gender, clinical stage, and performance status. Fatty acids were assayed by gas chromatography and compared among the three matched groups. There were no differences between the major depression group and nondepression group in any FAs. The minor depression group had higher mean levels of docosahexaenoic acid (mean7s. Major and minor depressions are one of the most common psychiatric problems in clinical oncological settings (Derogatis et al, 1983;Razavi and Stiefel, 1994;McDaniel et al, 1995). Docosahexaenoic acid (DHA), one of the omega-3 fatty acids (FAs), is a major component of membrane FAs in brain neural cells and lack of DHA has been shown to alter neural transmission in animal studies (Bruinsma and Taren, 2000;Innis, 2000;Ng and Innis, 2003). Previous studies have shown associations between DHA or its precursor, eicosapentaenoic acid (EPA, omega-3 FA), and major depression in subjects without cancer (Edwards et al, 1998;Hibbeln, 1998;Peet et al, 1998;Maes et al, 1999). Other studies have shown their possible therapeutic potential with few adverse effects in clinical trials (Nemets et al, 2002;Peet and Horrobin, 2002;Su et al, 2003). In the oncological setting, the use of antidepressants has been limited due to their adverse effects (Akizuki et al, 2002;Fisch, 2004). In our previous pilot study to obtain information for planning interventional research, depression in cancer patients was not associated with either EPA or DHA intakes, but was associated with lower intake of alpha-linolenic acid (ALA: major omega-3 FAs in diet, precursor of EPA and DHA) (Suzuki et al, 2004). To elucidate any such association in detail, the present study was designed to examine our hypothesis that lower levels of omega-3 FAs (EPA, DHA) in serum phospholipids are associated with major and minor depression in lung cancer patients. MATERIALS AND METHODS Study design and subjectsThe present study was a three matched group case -control study, based in part on the Lung Cancer Database Project, which was a prospective cohort study for investigation of the pathogenesis of and development of new therapy for lung cancer at the National Cancer Center Hospital East and the National Cancer Center Research Institute East, ...

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Section: Serum Fatty Acid and Depression In Cancer Patients M Kobayakmentioning

confidence: 91%

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confidence: 99%

Levels of omega-3 fatty acid in serum phospholipids and depression in patients with lung cancer

et al. 2005

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“…Epidemiological findings linking depression and low levels of fish intake have been reported (Hibbeln, 1998;Tanskanen et al, 2001), and biochemical research has also shown that the concentrations of each o-3 FA are significantly lower in the serum or red blood cell membranes of depressed patients than in control subjects (Edwards et al, 1998;Peet et al, 1998;Maes et al, 1999). Ethyl-EPA augmentation therapy has been reported to improve depressive symptoms in patients with major depression in randomised placebo-controlled double-blind clinical trials (Nemets et al, 2002;Peet and Horrobin, 2002) and in one clinical report (Puri et al, 2002).…”

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confidence: 99%

Daily omega-3 fatty acid intake and depression in Japanese patients with newly diagnosed lung cancer

et al. 2004

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The aim of the present study was to examine the association between daily omega-3 fatty acid intake and depression in Japanese cancer patients. Omega-3 fatty acid intake in 771 patients with newly diagnosed primary lung cancer was evaluated using a foodfrequency questionnaire, and the prevalence of depression was examined using the cutoff values for the depression subscale included in the Hospital Anxiety and Depression Scale. After adjustment for potential confounding factors, the odds ratio (OR) for depression among patients in the highest quartile of the total eicosapentaenoic acid-(C20:5n-3) and docosapentaenoic acid (C22:6n-3)-intake group compared with patients in the lowest quartile was not significantly different. On the other hand, the OR among the highest quartile of a-linolenic acid (C18:3n-3) intake (adjusted OR ¼ 0.50, 95% CI: 0.31 -0.71, P for trend ¼ 0.004) and the highest quartile of total omega-3 fatty acid intake (adjusted OR ¼ 0.55, 95% CI: 0.35 -0.88, P for trend ¼ 0.022) were significantly different. These results suggest that total eicosapentaenoic acid and docosapentaenoic acid intake might not be associated with depression in Japanese patients with newly diagnosed lung cancer, but that a-linolenic acid intake and total omega-3 fatty acid intake might be.

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“…Taken together the results indicate that there are no immediate effects on mental health after short-term intervention with either healthy school meals or n-3 LCPUFA supplementation in typically developing children and adolescents. Cross-sectional and prospective studies show that fish consumption is associated with reduced levels of mental health problems in both children and adults [20–24], thus a longer exposure time than 3 months is possibly required in order to influence mental health. Given the low dietary compliance in the fatty fish group compared to the two other intervention groups, it is not certain whether an extension of time in the present study would have yielded a sufficient intake of fatty fish.…”

Section: Discussionmentioning

confidence: 99%

“…One study found an inverse relationship between fish consumption and major depression across countries [20] and two surveys from Finland found an association between infrequent fish intake and depression in women [21,22]. Longitudinal studies have also found a negative association between maternal intake of seafood during pregnancy and suboptimal child outcomes, such as IQ, social development and communication skills [23], as well as a negative association between the n-3 LCPUFAs, docosahexaenoic (DHA) status early in life and child internalizing problems (anxious/depressed) at 7 years of age [24].…”

Section: Introductionmentioning

confidence: 99%

The effect of school meals with fatty fish on adolescents’ self-reported symptoms for mental health: FINS-TEENS - a randomized controlled intervention trial

Skotheim

Handeland

Kjellevold³

et al. 2017

Food & Nutrition Research

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There is a growing body of evidence linking fish consumption and n-3 LCPUFAs to mental health. Still, the results from randomized trials with n-3 LCPUFAs show conflicting results, and it is possible that the combined effect of several nutrients in fish may explain the observed associations. To aim of the present study was to investigate if school meals with fatty fish three times per week for 12 weeks could alter mental health in a sample of typically developing adolescents. In the Fish Intervention Studies-TEENS (FINS-TEENS), adolescents from eight secondary schools (n=425) in Norway, were randomized to receive school meals with fatty fish, meat or n-3 LCPUFA supplements. Mental health was assessed with the Strengths and Difficulties Questionnaire (SDQ) and the differences between the groups were assessed with linear mixed effect models, unadjusted and adjusted for baseline and dietary compliance. The results showed no effects of school meals with fatty fish compared to similar meals with meat or n-3 LCPUFAs on the adolescents’ self-reported symptom scores for mental health. Among adolescents scoring above the SDQ cut-offs (high-scorers), the fish- improved less than the meat group in the self-reported symptom scores for total difficulties- and emotional problems. However, the findings should be regarded as preliminary, as the analyses for the high-scorer group were underpowered. In conclusion, serving school meals with fatty fish did not alter mental health in a typically developing sample of adolescents. It is possible that serving healthy school meals with meat is more beneficial than similar meals with fatty fish in adolescents scoring high on mental health problems. However, the results should be seen as preliminary, as the dietary compliance in the fish group was low and the analyses in the high score group underpowered. Thus, further studies should investigate the associations between fish consumption and adolescents’ mental health.

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Fish consumption and major depression

Cited by 791 publications

References 3 publications

Levels of omega-3 fatty acid in serum phospholipids and depression in patients with lung cancer

Levels of omega-3 fatty acid in serum phospholipids and depression in patients with lung cancer

Daily omega-3 fatty acid intake and depression in Japanese patients with newly diagnosed lung cancer

The effect of school meals with fatty fish on adolescents’ self-reported symptoms for mental health: FINS-TEENS - a randomized controlled intervention trial

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