The beneficial health effects of seafoods are attributed to their lipid components which are rich in long-chain polyunsaturated fatty acids of the omega-3 family. These lipids are responsible for the development of both desirable and undesirable flavors in marine-based food products. However, non-volatile cnstituents of seafoods, such as free amino acids, nucleotides, sugars and minerals, also contribute to the characteristic taste and flavor of seafoods. An overview of the evaluation of seafood flavors, studies related to their lipid constituents and important recent developments in the field is provided.The consumption and popularity of seafoods has consistently increased during recent years. Importance of seafoods in health and nutrition was revealed when Bang and Dyerberg (1-5) reported that Eskimos had low rates of coronary heart disease (CHD) and cancer despite their high-fat diet. It was further noted that fat in the Eskimos diet originated from fish and seal. Other epidemiological studies have also confirmed that the incidence of cardiovascular disease (CVD) in fish eating, non-Eskimo, populations was less prevalent than those who did not eat or consumed little fish (6-10). The potential beneficial health effects of seafoods have been ascribed to their lipids which contain a relatively large amount of long-chain omega-3 fatty acids. These omega-3 fatty acids are known to be effective in curing and treatment of certain CVD by lowering serum triacylglycerol and cholesterol and play an important role in the prevention and treatment of hypertension, arthritis and other inflamatory and autoimmune disorders. In addition, omega-3 forty acids, namely eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaeonic acid (DPA) are essential for normal growth. DHA is a major component of membrane phospholipids in retinal receptors, cerebral grey matter and sperm. Selective incorporation mechanisms appear to exist to supply the fetal brain and retina with the relatively high levels of DHA needed for normal brain development and eye sight Meanwhile, EPA serves as a precursor of eicosanoids which are hormone like substances such as prostaglandins, thromboxanes and leucotriens. These eicosanoids act on cellular messengers and metabolite regulators and are produced by different cell