Fish oil and COVID-19 thromboses

Merritt, Russell; Bhardwaj, Vrinda; Jami, Mohammad M.

doi:10.1016/j.jvsv.2020.07.002

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…Currently, there are a few publications analysing the antithrombotic properties of omega-3 PUFAs in patients hospitalized due to COVID-19 [ 84 , 85 ]. It is known that coagulopathy is frequently observed in many—especially severe—cases of COVID-19 and manifests as disseminated intravascular coagulation (DIC).…”

Section: Novel Perspectives Of Omega-3 Pufasmentioning

confidence: 99%

“…Omega-3 PUFAs are well known to have antithrombotic, anti-inflammatory, and pro-resolving properties that can yield positive effects in COVID-19 patients [ 87 ]. Since beneficial effects of fish oil/omega-3 PUFAs in limiting thrombosis have been confirmed in many disorders and clinical settings, it now appears logical to investigate the potential role of fish oil/omega-3 PUFAs supplementation as an adjunct to pharmacotherapy in COVID-19 patients at risk of vascular thrombotic complications [ 84 ].…”

Section: Novel Perspectives Of Omega-3 Pufasmentioning

confidence: 99%

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Effects of Omega-3 Polyunsaturated Fatty Acids and Their Metabolites on Haemostasis—Current Perspectives in Cardiovascular Disease

Golański

Szymańska

Różalski

2021

IJMS

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The beneficial effects of long-chain polyunsaturated omega-3 fatty acids (omega-3 PUFAs) in cardioprotection are widely known and generally accepted. In this literature review, we have focused on the known and postulated mechanisms of action of omega-3 PUFAs and their metabolites on various components of the haemostatic system, in particular on blood platelets and endothelium. We have also made an attempt to provide a comprehensive review of epidemiological studies with particular regard to clinical trials. Notably, the results of these studies are contradictory, and some of them failed to report the beneficial effects of taking or supplementing omega-3 PUFAs in the diet. A potential explanation, in our opinion, could be the need to use higher doses of omega-3 PUFAs and a proper ratio of omega-3 and omega-6 PUFAs. An additional problem which is difficult to solve is the use of a proper neutral placebo for interventional studies. Despite some controversies regarding the beneficial effects of supplementation of omega-3 PUFAs in cardiovascular disease, our review suggests that a promising aspect of future studies and applications is to focus on the anti-thrombotic properties of these compounds. An argument supporting this assumption is the recent use of omega-3 PUFAs as a supporting tool for the treatment of COVID-19 complications.

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Section: Novel Perspectives Of Omega-3 Pufasmentioning

confidence: 99%

Section: Novel Perspectives Of Omega-3 Pufasmentioning

confidence: 99%

Effects of Omega-3 Polyunsaturated Fatty Acids and Their Metabolites on Haemostasis—Current Perspectives in Cardiovascular Disease

Golański

Szymańska

Różalski

2021

IJMS

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“…Парентеральные формы жировых эмульсий (ЖЭ) уже имеют положительный опыт применения при поражении легких в условиях заражения COVID-19 [70] за счет улучшения оксигенации крови. Кроме того, внутривенные эмульсии на основе рыбьего жира, как считают некоторые исследователи [71,72], могут улучшать клинические результаты лечения септических состояний и ОРДС при COVID-19 при невозможности или неэффективности энтерального приема ЕРА и DHA. Это совпадает с результатами исследований этих ЖЭ в других областях медицины, связанных с регуляцией иммунитета.…”

Section: современные парентеральные формы омега-3 пнжкunclassified

Omega-3 fatty acids as component of nutritional and metabolic treatment of patients with COVID-19 and other viral diseases (literature review)

Дмитриев

Machulina

Шестопалов³

2021

Medicinskij alfavit

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Nutritional deficit in patients with viral diseases, including COVID-19, can reduce the efficacy of specific treatment, decrease the survival rate, and increase medical expenses. According to international guidelines, timely correction of nutritional status with supplemental enteral and parenteral nutrition containing omega-3 polyunsaturated fatty acid from fish oil (omega-3 PUFAs: ЕРА and DHA) is able to improve clinical outcomes of specific antiviral treatment. The authors conducted an analytical review to assess the results from the study of clinical use of omega-3 PUFAs for the prevention and treatment of COVID-19 and other viral infections. Supplementation of clinical (enteral and parenteral) nutrition with omega-3 PUFAs allows for symptom reduction, shorter stay in hospital, and quicker recovery of patients infected with SARS-CoV-2 and other viruses. When used in combination with adequate macronutrient support, it can reverse nutritional deficit and improve clinical outcomes.

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Strengthening the immunity of the Swiss population with micronutrients: A narrative review and call for action

Berger¹,

Herter-Aeberli²,

Zimmermann³

et al. 2021

Clinical Nutrition ESPEN

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Background The enormous health impact of the COVID-19 pandemic has refocused attention on measures to optimize immune function and vaccine response. Dietary deficiencies of micronutrients can weaken adaptive immunity. The aim of this review was to examine links between micronutrients, immune function and COVID-19 infection, with a focus on nutritional risks in subgroups of the Swiss population. Methods Scoping review on the associations between selected micronutrients (vitamins D and C, iron, selenium, zinc, and n-3 PUFAs) and immunity, with particular reference to the Swiss population. These nutrients were chosen because previous EFSA reviews have concluded they play a key role in immunity. Results The review discusses the available knowledge on links between sufficient nutrient status, optimal immune function, and prevention of respiratory tract infections. Because of the rapid spread of the COVID-19 pandemic, controlled intervention studies of micronutrients in the context of CIOVIUD-19 infection are now underway, but evidence is not yet available to draw conclusions. The anti-inflammatory properties of n-3 PUFAs are well established. In Switzerland, several subgroups of the population are at clear risk of nutrient deficiencies; e.g., older adults, multiple comorbidities, obesity, pregnancy, and institutionalized. Low intakes of n-3 PUFA are present in a large proportion of the population. Conclusion There are clear and strong relationships between micronutrient and n-3 PUFA status and immune function, and subgroups of the Swiss population are at risk for deficient intakes. Therefore, during the COVID-19 pandemic, as a complement to a healthy and balanced diet, it may be prudent to consider supplementation with moderate doses of Vitamins C and D, as well as of Se, Zn and n-3 PUFA, in risk groups.

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Fish oil and COVID-19 thromboses

Cited by 5 publications

References 11 publications

Effects of Omega-3 Polyunsaturated Fatty Acids and Their Metabolites on Haemostasis—Current Perspectives in Cardiovascular Disease

Effects of Omega-3 Polyunsaturated Fatty Acids and Their Metabolites on Haemostasis—Current Perspectives in Cardiovascular Disease

Omega-3 fatty acids as component of nutritional and metabolic treatment of patients with COVID-19 and other viral diseases (literature review)

Strengthening the immunity of the Swiss population with micronutrients: A narrative review and call for action

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