Fish Oil And/Or Probiotics Intervention in Overweight/Obese Pregnant Women and Overweight Risk in 24-Month-Old Children

Saros, Lotta; Vahlberg, Tero; Koivuniemi, Ella; Houttu, Noora; Niinikoski, Harri; Tertti, Kristiina; Laitinen, Kirsi

doi:10.1097/mpg.0000000000003659

Cited by 6 publications

(4 citation statements)

References 49 publications

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“…Step 3 establishes the appropriate dosage of the bioactive compounds [45][46]. In this review, we discovered that dosage varied from study to study [27,28,[30][31][32][33][34][35][36][37][38][39][45][46]. Therefore, researchers will need to refine the proper dosage for maximum benefits and minimal harm.…”

Section: Discussionmentioning

confidence: 99%

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Exploring the effectiveness of lactobacillus probiotics in weight management: A literature review

Williams¹,

Oo²,

Martirosyan³

2023

FFS

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The objective of this literature review was to evaluate the effectiveness of the exploring the effectiveness of lactobacillus probiotics in weight management: a literature review in weight management. Obesity is defined as the accumulation of excessive fat, which may result in many potential health risks. A body mass index over 30 is considered obese, and obesity rates have increased by over 400% since 1975. Obesity is one of the leading underlying causes of health issues in developed nations, causing problems such as cardiovascular disease, stroke, and certain cancers. Additionally, obesity is also known to be heavily associated with type ii diabetes, high blood pressure (hypertension), and musculoskeletal disorders. To combat the issues connected with obesity, diet, and exercise are essential. In this article, we recommend the use of probiotics’ biocompound from the genus lactobacillus in addition to diet and exercise as an intervention for obese individuals. Probiotics may facilitate weight loss by increasing microbiome quantity and variety, regulating immune responses, and improving metabolic rates. An online search was conducted in the following databases: pubmed® and the functional food center’s journal database. Studies published between January 1, 2010, and April 1, 2023, were included. More rcts are needed to increase the certainty of the evidence and to verify our conclusions, especially in those who have conditions that are comorbid with obesity, such as type 2 diabetes.Another major objective of this research will be reviewing accumulated data from the perspective of functional food definition and steps on how to create ideal functional food products. Functional foods, products that contain bioactive compounds, such as vitamins, minerals, antioxidants, and other beneficial substances, are crucial in promoting health and preventing diseases. Functional food science involves isolating and combining bioactive compounds to create functional ingredients that provide targeted health benefits. The development of functional food incorporates a multidisciplinary approach to food science, nutrition, biotechnology, and other related fields. Hence, by accumulating data on functional food science and by using quantum end tempus theories about bioactive compounds, researchers can provide valuable insights for creating ideal and innovative functional food products that meet consumer demands for healthier food options. Keywords:Obesity, probiotics, Lactobacillus, quantum theory of functional foods, type 2 diabetes

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Section: Discussionmentioning

confidence: 99%

“…Throughout the previous research, common biomarkers were body weight, BMI, WC, and HC [27,28,[30][31][32][33][34][35][36][37][38][39].…”

Section: Discussionmentioning

confidence: 99%

Exploring the effectiveness of lactobacillus probiotics in weight management: A literature review

Williams¹,

Oo²,

Martirosyan³

2023

FFS

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“…Findings revealed a significant improvement in longevity and cardiometabolic risk factors in treated subjects, including reduced serum lipids, inflammation (e.g., high-sensitivity CRP), blood pressure, insulin resistance, and a remarkable 50% reduction in diagnostic criteria for cardiometabolic syndrome and 38% decrease in Framingham 10-year cardiovascular risk. Supplementation of probiotics with fish oil and Vitamin D has also been investigated in overweight or obese individuals, resulting in decreased systemic inflammation after an eight-week treatment period [226] . A similar treatment was evaluated in a recent mother-infant clinical trial conducted in Finland [227] .…”

Section: Synbioticsmentioning

confidence: 99%

Probiotics, prebiotics, synbiotics and other microbiome-based innovative therapeutics to mitigate obesity and enhance longevity via the gut-brain axis

Boyajian,

Islam,

Abosalha

et al. 2024

Microbiome Res Rep

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The global prevalence of obesity currently exceeds 1 billion people and is accompanied by an increase in the aging population. Obesity and aging share many hallmarks and are leading risk factors for cardiometabolic disease and premature death. Current anti-obesity and pro-longevity pharmacotherapies are limited by side effects, warranting the development of novel therapies. The gut microbiota plays a major role in human health and disease, with a dysbiotic composition evident in obese and aged individuals. The bidirectional communication system between the gut and the central nervous system, known as the gut-brain axis, may link obesity to unhealthy aging. Modulating the gut with microbiome-targeted therapies, such as biotics, is a novel strategy to treat and/or manage obesity and promote longevity. Biotics represent material derived from living or once-living organisms, many of which have therapeutic effects. Pre-, pro-, syn- and post-biotics may beneficially modulate gut microbial composition and function to improve obesity and the aging process. However, the investigation of biotics as next-generation therapeutics has only just begun. Further research is needed to identify therapeutic biotics and understand their mechanisms of action. Investigating the function of the gut-brain axis in obesity and aging may lead to novel therapeutic strategies for obese, aged and comorbid (e.g., sarcopenic obese) patient populations. This review discusses the interrelationship between obesity and aging, with a particular emphasis on the gut microbiome, and presents biotics as novel therapeutic agents for obesity, aging and related disease states.

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“…According to Saros et al, probiotics (Lactobacillus rhamnosus HN001 and Bifidobacterium animalis ssp. lactis 420) administration alone or combined with fish oil during pregnancy and in the first 6 months postpartum decreased the risk of obesity in their offspring at the age of 24 months [81]. Interestingly, recent evidence suggests that probiotics administered in pregnant women might act as a gene-targeted therapy since they might significantly decrease the DNA methylation in certain gene promoters of obesity in both mothers and their children, subsequently decreasing the risk for excessive weight gain [82].…”

Section: Obesity Microbiota and Prebiotics Probiotics And Synbioticsmentioning

confidence: 99%

Prebiotics, Probiotics, and Synbiotics—A Research Hotspot for Pediatric Obesity

Borka Balas,

Meliț,

Lupu

et al. 2023

Microorganisms

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Childhood obesity is a major public health problem worldwide with an increasing prevalence, associated not only with metabolic syndrome, insulin resistance, hypertension, dyslipidemia, and non-alcoholic fatty liver disease (NAFLD), but also with psychosocial problems. Gut microbiota is a new factor in childhood obesity, which can modulate the blood lipopolysaccharide levels, the satiety, and fat distribution, and can ensure additional calories to the host. The aim of this review was to assess the differences and the impact of the gut microbial composition on several obesity-related complications such as metabolic syndrome, NAFLD, or insulin resistance. Early dysbiosis was proven to be associated with an increased predisposition to obesity. Depending on the predominant species, the gut microbiota might have either a positive or negative impact on the development of obesity. Prebiotics, probiotics, and synbiotics were suggested to have a positive effect on improving the gut microbiota and reducing cardio-metabolic risk factors. The results of clinical trials regarding probiotic, prebiotic, and synbiotic administration in children with metabolic syndrome, NAFLD, and insulin resistance are controversial. Some of them (Lactobacillus rhamnosus bv-77, Lactobacillus salivarius, and Bifidobacterium animalis) were proven to reduce the body mass index in obese children, and also improve the blood lipid content; others (Bifidobacterium bifidum, Bifidobacterium longum, Lactobacillus acidophilus, Lacticaseibacillus rhamnosus, Enterococcus faecium, and fructo-oligosaccharides) failed in proving any effect on lipid parameters and glucose metabolism. Further studies are necessary for understanding the mechanism of the gut microbiota in childhood obesity and for developing low-cost effective strategies for its management.

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Fish Oil And/Or Probiotics Intervention in Overweight/Obese Pregnant Women and Overweight Risk in 24-Month-Old Children

Cited by 6 publications

References 49 publications

Exploring the effectiveness of lactobacillus probiotics in weight management: A literature review

Exploring the effectiveness of lactobacillus probiotics in weight management: A literature review

Probiotics, prebiotics, synbiotics and other microbiome-based innovative therapeutics to mitigate obesity and enhance longevity via the gut-brain axis

Prebiotics, Probiotics, and Synbiotics—A Research Hotspot for Pediatric Obesity

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