Fish Oil Feeding Up-Regulates the Expression of 5-Aminolevulinate Synthase 2 mRNA in Rat Brain

Haraguchi, Tomoaki; Yanaka, Noriyuki; Eguchi, Yuko; Kudo, Takahiro; Hirata, A; Katô, Norihisa

doi:10.1271/bbb.110121

Cited by 2 publications

(1 citation statement)

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“…DHA, EPA and their metabolites are demonstrated to possess anti-excitotoxic, antioxidant, anti-apoptotic, and anti-inflammatory properties [3]. Further, DHA is shown to reduce oxidative stress in the brain [4], and recent experimental evidence ascribes a neurotrophic action of EPA [5].…”

Section: Introductionmentioning

confidence: 99%

Fish Oil Prophylaxis Protects against 3-Nitropropinic Acid-Induced Oxidative Impairments in Striatum and Cerebellum in Male Rat Brain

Kollareth¹,

Babu²,

Bharath³

et al. 2017

Neurochem Neuropharm

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Increasing evidence supports a role for fish oil (FO) and the n-3 polyunsaturated fatty acids (n-3 PUFA) -docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), in protecting against neurodegeneration. However, experimental evidence on their neuroprotective efficacy in neurotoxin models is rather limited. In the present study, we examined whether pretreatment with n-3 PUFA in SH-SY5Y cells and FO prophylaxis in rats would render them less susceptible to 3-nitropropionic acid (a mitochondrial toxin, NPA) exposure. Cells pretreated with DHA/EPA were more resistant to NPA-induced perturbations in antioxidant defenses and exhibited higher survival rate. Further, we validated these findings among growing rats provided with FO (4 mL/kg bw) prophylaxis for 4 weeks and subjected to NPA challenge (25 mg/kg bw/d during last 4 d). Interestingly, FO prophylaxis offered significant protection against NPA -induced oxidative dysfunctions and depleted dopamine levels in striatum. Based on our in vitro and in vivo findings, we hypothesize that the protective effect of FO may be wholly or in part related to its potential to enhance GSH, thiols and antioxidant defenses in specific regions of brain of rats. Thus FO prophylaxis is likely to offer a therapeutic advantage as a neuroprotective strategy under oxidative stress-mediated neurodegenerative conditions.

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Section: Introductionmentioning

confidence: 99%