Fish oil supplementation enhances colon recovery after experimental colitis

Fish Oil Ameliorates Vibrio parahaemolyticus Infection in Mice by Restoring Colonic Microbiota, Metabolic Profiles, and Immune Homeostasis

“…Dietary n -3 PUFAs have made great achievements in the management of various diseases, such as intestine pathological damage . FO appears to be able to restore the damaged colonic tissue to a healthy state . Interestingly, pretreatment with 4 mg of FO improved the Vp-induced colonic damage, suggesting that the specific dose of FO was a potential intestinal structure and function-enhancer.…”

“…41 FO appears to be able to restore the damaged colonic tissue to a healthy state. 42 Interestingly, pretreatment with 4 mg of FO improved the Vp-induced colonic damage, suggesting that the specific dose of FO was a potential intestinal structure and function-enhancer. Our findings are consistent with other recent studies that showed that FO can provide relief in inflammatory bowel disease.…”

Effect of Lifelong Exposure to Dietary Plant and Marine Sources of n-3 Polyunsaturated Fatty Acids on Morphologic and Gene Expression Biomarkers of Intestinal Health in Early Life

“…The intestinal-health-promoting effects of n -3 PUFA supplementation have been studied in the context of established conditions with compromised intestinal health, such as obesity [ 11 ], obesity-associated colitis [ 46 ], or IBD/experimental colitis studies using long-chain n -3 PUFA from marine/fish oil [ 47 , 48 , 49 , 50 ] or plant/flaxseed oil [ 47 , 51 , 52 , 53 ], with some studies reporting no beneficial effects [ 54 , 55 , 56 ]. Additionally, there is evidence that n -3 PUFA can also promote intestinal healing and restoration of the intestinal epithelial barrier [ 48 , 54 ].…”

“…The intestinal-health-promoting effects of n -3 PUFA supplementation have been studied in the context of established conditions with compromised intestinal health, such as obesity [ 11 ], obesity-associated colitis [ 46 ], or IBD/experimental colitis studies using long-chain n -3 PUFA from marine/fish oil [ 47 , 48 , 49 , 50 ] or plant/flaxseed oil [ 47 , 51 , 52 , 53 ], with some studies reporting no beneficial effects [ 54 , 55 , 56 ]. Additionally, there is evidence that n -3 PUFA can also promote intestinal healing and restoration of the intestinal epithelial barrier [ 48 , 54 ]. This indicates that the overall effect of n -3 PUFA within the intestinal microenvironment can both strengthen intestinal barrier defenses and promote resolution of compromised barrier defenses, but the specific mechanisms in an unchallenged intestinal microenvironment need to be determined.…”