Fish oil supplementation improves large arterial elasticity in overweight hypertensive patients

Wang, S; Aq, Ma; Sw, Song; Qh, Quan; Xf, Zhao; Zheng, Xueli

doi:10.1038/sj.ejcn.1602886

Cited by 40 publications

(39 citation statements)

References 27 publications

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“…A summary of the International Study of Macro/Micronutrients and Blood Pressure (INTERMAP) reported that total PUFA, linoleic acid (LA), total n-3 FA, and α-linolenic acid (ALA), were inversely associated with BP (10). Data from meta-analyses (11,12) and clinical trials (13,14) have indicated that n-3 PUFA supplementation dose-dependently reduces BP in hypertensive patients, but not in normotensive individuals. A large-scale, population-based INTERMAP indicated that dietary intake of n-3 PUFA was inversely associated with BP levels in middle-aged normotensive individuals (15).…”

Section: Introductionmentioning

confidence: 99%

Low levels of linoleic acid and α-linolenic acid and high levels of arachidonic acid in plasma phospholipids are associated with hypertension

Tsukamoto

Sugawara

2017

biom rep

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Abstract.Dietary fat is an important determinant in the development and progression of high blood pressure (BP), a major risk factor for cardiovascular diseases and mortality. The aim of the present study was to determine the association between plasma phospholipid fatty acids and hypertension in Japanese men. The plasma level of linoleic acid (LA) in the subjects with hypertension (systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg) was identified to be significantly higher than that in the healthy controls. Following adjustment for age, body mass index, physical activity, smoking status, alcohol consumption, salt intake, and serum levels of glucose and hemoglobin A1c, higher plasma levels of LA and α-linolenic acid (ALA), and lower levels of arachidonic acid (AA) were significantly associated with a lower prevalence of hypertension. The odds ratio (OR) for the highest quartile (Q4) versus the lowest quartile (Q1) of LA was 0.17 (P=0.003), the OR for Q4 versus Q1 of ALA was 0.26 (P=0.042) and the OR for Q4 versus Q1 of AA was 2.04 (P= 0.047). These results indicate that elevated levels of LA and ALA, and reduced levels of AA in the plasma prevent hypertension.

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Section: Introductionmentioning

confidence: 99%

Low levels of linoleic acid and α-linolenic acid and high levels of arachidonic acid in plasma phospholipids are associated with hypertension

Tsukamoto

Sugawara

2017

biom rep

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“…Although the underlying mechanisms remain to be elucidated, the rapidity with which oral doses of SLO improve vascular structures and/or functions indicates a direct effect on the physiological components rather than the structural components that regulate the elasticity of the arterial wall, as was observed for vitamin E (34), as well as for fish oil (35,36) and n-3 long-chain fatty acids (37,38).…”

Section: Discussionmentioning

confidence: 99%

Vascular effects and safety of supplementation with shark liver oil in middle-aged and elderly males

Hamadate¹,

Matsumoto²,

Seto³

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Shark liver oil (SLO) has long been used as a traditional health food, with a particular benefit for vascular health, in Japan. The aim of this study was to assess the effect of dietary supplementation with SLO on arterial stiffness and peripheral microvascular function in otherwise healthy middle-aged and older males with slightly increased arterial stiffness. A randomized, double-blind, placebo-controlled, parallel study design was used to assign 41 healthy males with a mean age of 59.0±4.0 years (range, 45-69 years) to either SLO (n=21) or placebo (n=20) treatment for eight weeks. The effects on arterial stiffness and peripheral microvascular function were assessed by the cardio-ankle vascular index (CAVI) and by measurement of hand blood flow to cutaneous tissues using a laser Doppler perfusion imaging (LDPI) technique, respectively. Although the magnitude of the changes in the CAVI value during the eight-week intervention for the SLO group did not significantly differ from that for the placebo group, the changes in the CAVI value for the former group were significantly associated (r=0.575, P<0.01) with age. It was also found that the LDPI values at week 8 were significantly lowered (P<0.05) compared with the baseline values in the placebo group, while no change was observed in the SLO group, resulting in a significant difference in the changes between the two groups (P=0.002). Neither SLO supplementation-related adverse side-effects nor any abnormal changes in routine laboratory tests, including lipid profiles and anthropometric and haemodynamic parameters, were observed throughout the intervention. SLO may have the potential to safely improve vascular health in middle-aged and elderly males. IntroductionShark liver oil (SLO) has long been used as a dietary supplement with health-promoting activities, particularly for cardiovascular health, in Japan. At present, several SLO-containing supplements are commercially available and their dietary consumption is increasing among the Japanese middle-aged and elderly populations, most likely due to the fact that there has been considerable interest in alternative therapies.SLO is known to contain large quantities of squalene and, thus, to be considered as the richest source of the compound. Squalene received its name as a result of its first isolation from liver oil of sharks (Squalus spp.) (1). Later, squalene was found in variety of vegetable oils, including olive, palm, wheat-germ and rice bran oils. Chemically, squalene is a polyprenyl compound, having a structural similarity with β-carotene, coenzyme Q10 and vitamins A, E and K (2). Among these squalene-related compounds, vitamin E, known as the most potent lipid-soluble antioxidant in vivo, has been most intensively studied for its effects on cardiovascular health; there have been a number of studies reporting that vitamin E is effective in decreasing arterial stiffening in overweight hypertensive patients (3,4), and others reporting that vitamin E supplementation improves peripheral vascular disease...

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“…Based on secular trends in the United States and the United Kingdom, the greater reduction in stroke mortality from 1990 through 2002 in the U.S. have been tentatively attributed to the introduction of folic acid fortification [8]. A previous meta-analysis of published results from some of the folic acid trials, reported that folic acid could reduce the risk of stroke [9]. Under normal metabolic circumstances, there is a strict balance between Hcy formation and elimination.…”

Section: Homocysteine and Risk Of Cvdmentioning

confidence: 99%

Impact of Intervention with Co-Enzyme Q10 on Homocysteine Levels of Cardiac Patients with Established Angiographic Evidence

Mathur¹

2014

JCTCD

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Nutritionists and Health care professionals, epidemiologists and International agencies like WHO have been sounding an alarm on the remarkable increase in the incidence of Cardiovascular Diseases (CVD) for the past 15 years all around the world. It has been estimated that by 2020, CVD will be the largest cause of disability and death in India, which is the major reason why clinical research in this field is extremely relevant. The present study was undertaken to assess the nutritional status of twenty subjects suffering from coronary artery disease, cardiomyopathy, hypertension, mitral valve prolapse or coronary revascularisation with established angiographic evidence. Complete nutritional status assessment was done which included anthropometric, dietary and biochemical estimations. These subjects were then given 100 mg soft gel capsules of Coenzyme Q10 for a period of 60 days (this Intervention Trial was duly approved by the Institutional Ethics Committee). The study revealed that although the Body Mass Index (BMI) of the subjects was in the normal range they had high Waist/Hip Ratios indicating that central obesity was one of the risk factors for their CVD. The diets were found to be high in total fats and saturated fats, low in protein, fibre, and omega 3 fatty acids. The biochemical profile showed that the subjects had high levels of fasting and PP blood sugar and Lipoprotein A. homocysteine levels were found to be very high as compared to the normal values (p ≤ 0.01) in all the cardiac subjects prior to intervention. The subjects were asked to give their consent for the 60 days Intervention Trial with 100 mg of Coenzyme Q10 on Informed Consent Sheets. After Intervention all the Biochemical tests were conducted again. Results revealed that the impact of Coenzyme Q10 in lowering blood Sugar, Cholesterol, TG, LDL and Lipoprotein A levels was not significant which may be due to a modest dose and short intervention period of 60 days. homocysteine is a new emerging and independent risk factor for CVD There was a significant reduction (p ≤ 0.01) in the blood homocysteine (Hcy) levels of the subjects (from 22.52 ± 10.13 to17.08 ± 6.21). Hence in conclusion it can be said that Coenzyme Q10 is a rich, powerful and safe antioxidant with many beneficial therapeutic properties. Its supplements in the diet along with a diet which is rich in folic acid, both of which have a role in the correction of hyper homocysteinemia, can go a long way in the prevention of the global epidemic of CVD in the future times to come.

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Fish oil supplementation improves large arterial elasticity in overweight hypertensive patients

Cited by 40 publications

References 27 publications

Low levels of linoleic acid and α-linolenic acid and high levels of arachidonic acid in plasma phospholipids are associated with hypertension

Low levels of linoleic acid and α-linolenic acid and high levels of arachidonic acid in plasma phospholipids are associated with hypertension

Vascular effects and safety of supplementation with shark liver oil in middle-aged and elderly males

Impact of Intervention with Co-Enzyme Q10 on Homocysteine Levels of Cardiac Patients with Established Angiographic Evidence

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