Fish oil suppresses obesity more potently in lean mice than in diet-induced obese mice but ameliorates steatosis in such obese mice

Okue, Sachiko; Ishikawa, Emi; Nakahara, Ren; Ito, Tsubasa; Okura, Takumi; Sakae, Mana; Miura, Asako; Ozaki-Masuzawa, Yori; Hosono, Takashi; Seki, Taiichiro

doi:10.1093/bbb/zbaa038

Cited by 3 publications

(3 citation statements)

References 34 publications

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“…In addition, the changes in gene expression involved in heat production identified in BAT of mice fed the LD and the FOD were not similarly observed in the inguinal WAT in this study. Okue et al [10] reported that UCP-1 expression did not increase in the inguinal WAT of DIO mice fed diets containing FO for 4 weeks, which is consistent with our results. It has been reported that a high-fat diet decreases β3AR and UCP-1 expression in WAT [25,26].…”

Section: Discussionsupporting

confidence: 93%

“…However, most of these studies on the thermogenic effects of FO in mice have been conducted in nonobese mice, and it is unclear whether FO exerts its thermogenic effects in obese mice. Okue et al [10] reported that FO did not induce the expression of UCP1 in inguinal WAT in diet-induced obese (DIO) mice, but they did not report the effects of FO on BAT or body temperature. To determine whether FO has a thermogenic effect in obese animals, we fed FO to DIO mice and examined changes in body weight, rectal temperature, and expression of heat production-related genes in BAT and inguinal WAT.…”

Section: Introductionmentioning

confidence: 99%

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The anti-obesity effect of fish oil in diet-induced obese mice occurs via the induction of heat production in brown but not white adipose tissue

Obo,

Hashiguchi,

Matsuda

et al. 2023

Preprint

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Aims/Introduction: The ω3 polyunsaturated fatty acids in fish oil enhance heat production in adipocytes and exert anti-obesity effects, but the effects of fish oil on heat production in diet-induced obese (DIO) mice are unclear. In this study, we examined whether diets containing fish oil increased the expression of heat-producing genes in adipose tissue and increased body temperature in DIO mice, resulting in weight loss. We also examined fibroblast growth factor 21 (FGF21) levels in blood and the expression of the FGF21 gene in adipose tissue of DIO mice fed fish oil. Materials and Methods: C57BL6/J mice were fed a lard-based high-fat diet for 8 weeks starting at 5 weeks of age and then divided into two groups: one group was fed a fish oil-based high-fat diet, and the other group was fed a lard-based high-fat diet continuously for another 8 weeks. Mice fed a control diet for 16 weeks from the age of 5 weeks served as the control group. Mice were dissected at 21 weeks and used for analysis. Results: Mice fed a fish oil-based high-fat diet lost body weight gain, adipose tissue weight gain, and reduced insulin/leptin resistance. In addition, the rectal temperatures of mice fed a fish oil-based high-fat diet remained higher. The administration of fish oil increased the expression of heat-producing genes in brown adipose tissue (BAT) but did not alter heat-producing genes in inguinal white adipose tissue (WAT). In DIO mice fed a fish oil-based high-fat diet, the FGF21 expression in BAT increased. Furthermore, βklotho expression in BAT increased and the blood FGF21 concentration was decreased compared to mice fed a lard-based high-fat diet. Conclusions: In DIO mice, fish oil was shown to increase rectal temperature and ameliorate obesity. Furthermore, fish oil enhanced heat production in BAT, but not WAT, in DIO mice.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

The anti-obesity effect of fish oil in diet-induced obese mice occurs via the induction of heat production in brown but not white adipose tissue

Obo,

Hashiguchi,

Matsuda

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…In addition, the changes in gene expression involved in heat production identi ed in BAT of mice fed the LD and the FOD were not similarly observed in the inguinal WAT in this study. Okue et al [10] reported that UCP-1 expression did not increase in the inguinal WAT of DIO mice fed diets containing FO for 4 weeks, which is consistent with our results. It has been reported that a high-fat diet decreases β3AR and UCP-1 expression in WAT [25,26].…”

Section: Discussionsupporting

confidence: 93%

Fish oil induces thermogenesis in diet-induced obese mice in brown adipose tissue, but not in white adipose tissue.

Obo,

Hashiguchi,

Matsuda

et al. 2024

Preprint

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The ω3 polyunsaturated fatty acids in fish oil enhance heat production in adipocytes and exert anti-obesity effects, but the effects of fish oil on heat production in diet-induced obese (DIO) mice are unclear. We examined whether diets containing fish oil increased the expression of heat-producing genes in adipose tissue and increased body temperature in DIO mice, resulting in weight loss. C57BL6/J mice were fed a lard-based high-fat diet for 8 weeks starting at 5 weeks of age and then divided into two groups: one group was fed a fish oil-based high-fat diet, and the other group was fed a lard-based high-fat diet continuously for another 8 weeks. Mice fed a fish oil-based high-fat diet lost body weight gain, adipose tissue weight gain, and reduced insulin/leptin resistance. In addition, the rectal temperatures of mice fed a fish oil-based high-fat diet remained higher. In DIO mice fed a fish oil-based high-fat diet, the FGF21 expression in BAT increased. In conclusion, the administration of fish oil increased the expression of heat-producing genes in brown adipose tissue (BAT) but did not alter heat-producing genes in inguinal white adipose tissue (WAT).

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Thermogenic adipose tissues: Promising therapeutic targets for metabolic diseases

Pahlavani,

Pham,

Kalupahana

et al. 2025

The Journal of Nutritional Biochemistry

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Fish oil suppresses obesity more potently in lean mice than in diet-induced obese mice but ameliorates steatosis in such obese mice

Cited by 3 publications

References 34 publications

The anti-obesity effect of fish oil in diet-induced obese mice occurs via the induction of heat production in brown but not white adipose tissue

The anti-obesity effect of fish oil in diet-induced obese mice occurs via the induction of heat production in brown but not white adipose tissue

Fish oil induces thermogenesis in diet-induced obese mice in brown adipose tissue, but not in white adipose tissue.

Thermogenic adipose tissues: Promising therapeutic targets for metabolic diseases

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