Fish Oncology

Vergneau‐Grosset, Claire; Nadeau, Marie-Ève; Groff, J. M.

doi:10.1016/j.cvex.2016.07.002

Cited by 38 publications

(44 citation statements)

References 144 publications

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“…Intriguingly, non-mammalian organisms, which rely more on innate immunity-based mechanisms for their defence from microbes and parasites, suffer from tumours that have different behaviours from those occurring in mammals. Indeed, tumours in fish mostly affect blood cells, and solid tumours including carcinomas and sarcomas which are rare in these species, are mostly locally invasive and rarely metastatic [ 104 ]. Amphibians are also very resistant to cancer development as only two types of tumours are known in these species, including the renal adenocarcinoma of Rana pipiens and the lymphosarcoma of Xenopus laevis [ 105 ].…”

Section: Discussionmentioning

confidence: 99%

“…8: 180081 selection and likely reproductive rates, predation, lifespan and many other factors determine overall cancer rates. It is, however, worth mentioning that placental mammals, in particular the ones with highly invasive haemochorial placentas, have the highest malignant cancer rates among all animals [103]. It would be interesting to compare different types of placentation with the rates of malignancies in different species.…”

Section: Discussionmentioning

confidence: 99%

“…It would be interesting to compare different types of placentation with the rates of malignancies in different species. Interestingly, metastatic solid tumours have not been reported so far in non-placental mammals such as monotremes, which lay eggs rather than bearing live young [103]. Intriguingly, non-mammalian organisms, which rely more on innate immunity-based mechanisms for their defence from microbes and parasites, suffer from tumours that have different behaviours from those occurring in mammals.…”

Section: Discussionmentioning

confidence: 99%

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Exploring the links between cancer and placenta development

et al. 2018

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The development of metastatic cancer is a multistage process, which often requires decades to complete. Impairments in DNA damage control and DNA repair in cancer cell precursors generate genetically heterogeneous cell populations. However, despite heterogeneity most solid cancers have stereotypical behaviours, including invasiveness and suppression of immune responses that can be unleashed with immunotherapy targeting lymphocyte checkpoints. The mechanisms leading to the acquisition of stereotypical properties remain poorly understood. Reactivation of embryonic development processes in cells with unstable genomes might contribute to tumour expansion and metastasis formation. However, it is unclear whether these events are linked to immune response modulation. Tumours and embryos have non-self-components and need to avoid immune responses in their microenvironment. In mammalian embryos, neo-antigens are of paternal origin, while in tumour cells DNA mismatch repair and replication defects generate them. Inactivation of the maternal immune response towards the embryo, which occurs at the placental–maternal interface, is key to ensuring embryonic development. This regulation is accomplished by the trophoblast, which mimics several malignant cell features, including the ability to invade normal tissues and to avoid host immune responses, often adopting the same cancer immunoediting strategies. A better understanding as to whether and how genotoxic stress promotes cancer development through reactivation of programmes occurring during early stages of mammalian placentation could help to clarify resistance to drugs targeting immune checkpoint and DNA damage responses and to develop new therapeutic strategies to eradicate cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Exploring the links between cancer and placenta development

et al. 2018

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“…In fact, a study by Madsen et al [ 20 ] demonstrates that reptiles in French zoo parks even have significantly higher cancer frequency than mammals. Similarly, cancer is widespread in fish, although malignant neoplasms with or without metastasis are reported ‘less commonly than in mammals’ [ 15 ]. Indeed, some amphibians (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Xenopus ) and fish (e.g. Danio/Bracydanio rerio , zebrafish) are used as models in cancer research specifically because they show high cancer frequency, regeneration, effects of regenerative tissue on cancer growth (negative), and because their tumours resemble human tumours both histologically and at a genetic level of expression [ 15 ]. While plants have orthologous tumour suppressors and oncogenes, mutations in these genes usually do not become cancerous and cell walls prevent metastasis [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Ectothermic telomeres: it's time they came in from the cold

Olsson

Wapstra

Friesen

2018

Phil. Trans. R. Soc. B

122

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We review the evolutionary ecology and genetics of telomeres in taxa that cannot elevate their body temperature to a preferred level through metabolism but do so by basking or seeking out a warm environment. This group of organisms contains all living things on earth, apart from birds and mammals. One reason for our interest in this synthetic group is the argument that high, stable body temperature increases the risk of malignant tumours if long, telomerase-restored telomeres make cells ‘live forever’. If this holds true, ectotherms should have significantly lower cancer frequencies. We discuss to what degree there is support for this ‘anti-cancer’ hypothesis in the current literature. Importantly, we suggest that ectothermic taxa, with variation in somatic telomerase expression across tissue and taxa, may hold the key to understanding ongoing selection and evolution of telomerase dynamics in the wild. We further review endotherm-specific effects of growth on telomeres, effects of autotomy (‘tail dropping’) on telomere attrition, and costs of maintaining sexual displays measured in telomere attrition. Finally, we cover plant ectotherm telomeres and life histories in a separate ‘mini review’.This article is part of the theme issue ‘Understanding diversity in telomere dynamics'.

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Noninfectious Diseases (Other)

Hadfield

2021

Clinical Guide to Fish Medicine

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Fish Oncology

Cited by 38 publications

References 144 publications

Exploring the links between cancer and placenta development

Exploring the links between cancer and placenta development

Ectothermic telomeres: it's time they came in from the cold

Noninfectious Diseases (Other)

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