Fish scale-derived scaffolds with MSCs loading for photothermal therapy of bone defect

Shen, Siyu; Li, Rui; Song, Chuanhui; Shen, Tao; Zhou, Yiwen; Guo, Jingjie; Kong, Bin; Jiang, Qing

doi:10.1007/s12274-023-5460-1

Cited by 22 publications

(11 citation statements)

References 29 publications

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“…Furthermore, BP nanosheets contributed to photothermal conversion, which enabled the NIR PTT, further facilitating osteogenesis and bone regeneration (Figure 10e). [242] However, due to their easy decomposition, the degradation speed of BP needs to be controlled when applied in vivo, which limits its clinical translation. [243] Furthermore, it is worth highlighting that a core-shell structural nanorod-like array with HAp as a core and PDA as an amorphous shell (PDA@HAp) was found to achieve periodic PTT at a mild temperature (41 ± 1 °C), further accelerating the transition of MΦ adhered to PDA@HAp from M1 to M2 phenotype both in vitro and in vivo (Figure 10f).…”

Section: Photothermal Therapymentioning

confidence: 99%

“…Reproduced with permission. [ 242 ] Copyright 2023, Tsinghua University Press. f) Schematic illustration showing the PTT process in vitro for evaluation of the phenotypic transformation of Mφs cultured on PDA@HAp (top) and the experimental process in vivo to evaluate the immune responses and osteogenesis modulated by the implant with NIR radiation (bottom).…”

Section: Impact Of Heatmentioning

confidence: 99%

Section: Impact Of Heatmentioning

confidence: 99%

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Materials‐Mediated In Situ Physical Cues for Bone Regeneration

Liu,

Zhang,

et al. 2023

Adv Funct Materials

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Physical cues like morphology, light, electric signal, mechanic signal, magnetic signal, and heat can be used as alternative regulators for expensive but short‐acting growth factors in bone tissue engineering to promote osteogenic differentiation and bone regeneration. As physical stimulation applied directly to the tissue cannot be focused on the bone defect area to regulate the cell behaviors and fate in situ, this limits the efficiency of precise bone regeneration. Biomaterials‐mediated in situ physical cues, as an effective strategy combining the synergistic effect of materials themselves, are put forward and studied widely to promote osteogenic differentiation and bone repair efficiently and precisely. Different types of physical cues provide different choices to better satisfy the requirements for targeted bone defect repair. In this review, the recent research about different biomaterials‐mediated physical cues accelerating osteogenesis in vitro and promoting in situ bone formation in vivo is introduced. Meanwhile, the corresponding possible mechanisms of various physical cues regulating cell responses are also discussed. This review provides useful and enlightening guidance for the utilization of intrinsically physical properties of functional materials to achieve efficient bone regeneration, leading to the design and construction of smart biomaterials for practical applications, and eventually promoting clinical translation.

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Section: Photothermal Therapymentioning

confidence: 99%

Section: Impact Of Heatmentioning

confidence: 99%

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Materials‐Mediated In Situ Physical Cues for Bone Regeneration

Liu,

Zhang,

et al. 2023

Adv Funct Materials

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“…18 Moreover, FGel with good biocompatibility and low immunogenicity has been broadly applied in the field of biomedical materials, including bone repair and wound healing. 19,20 However, the mechanical property of FGel hydrogels is usually unsatisfactory, which showed lower stretchable ability. 21−23 At present, various methods for enhancing the mechanical properties of hydrogels have been reported, such as nanoreinforced hydrogels, interpenetrating network hydrogels, DN hydrogels, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Fish gelatin (FGel) obtained from the hydrolysis of fibrin collagen derived from fish skin or fish scales under heat and acidic conditions showed advantages over gelatin from pig skin etc., such as excellent wound healing ability and no religious restrictions . Moreover, FGel with good biocompatibility and low immunogenicity has been broadly applied in the field of biomedical materials, including bone repair and wound healing. , However, the mechanical property of FGel hydrogels is usually unsatisfactory, which showed lower stretchable ability. − At present, various methods for enhancing the mechanical properties of hydrogels have been reported, such as nanoreinforced hydrogels, interpenetrating network hydrogels, DN hydrogels, etc. , Among these methods, fabricating DN hydrogels with two relatively independent single hydrogel networks is a feasible way to improve mechanical properties, due to the unique contrasting network structures, strong interpenetrating network entanglement, and efficient energy dissipation. As a special class of interpenetrating network hydrogels, DN hydrogels have been widely applied in improving the mechanical performance of hydrogels since 2003. − Du et al have fabricated DN hydrogels composed of FGel and agarose, which showed high strength and toughness.…”

Section: Introductionmentioning

confidence: 99%

Highly Stretchable, Transparent, and Adhesive Double-Network Hydrogel Dressings Tailored with Fish Gelatin and Glycyrrhizic Acid for Wound Healing

Sun,

Zang

et al. 2023

ACS Appl. Mater. Interfaces

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Cornea‐Inspired Ultrasound‐Responsive Adhesive Hydrogel Patches for Keratitis Treatment

Kong,

Liu,

et al. 2023

Adv Funct Materials

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Biomedical patches offer significant potential for keratitis treatment. Building on advances in multifunctionality and biomimicry, an innovative, multifunctional hydrogel patch with high therapeutic efficacy, inspired by the native architecture and functions of the cornea, is introduced. By engineering a composite patch comprising recombinant human collagen (RHC) hydrogel, near‐field electrospinning (NFES) microfibers, and gold‐nanoparticle‐decorated tetragonal barium titanates (BTO@Au), structural mimicry, mechanical reinforcement, tissue‐specific adhesion, and bacterial inhibition are achieved. The RHC hydrogel recreates a three‐dimensional (3D) microenvironment that emulates the natural structure of the corneal tissue, demonstrating excellent tissue adhesion. Integrated within this hydrogel, the NFES microfibers, designed to emulate the orthogonal arrangement of native corneal stroma, not only reinforce the mechanical strength of the RHC hydrogel but also act as scaffolds to guide the aligned growth of human keratocytes. A unique aspect of this advanced patch is the incorporation of BTO@Au nanoparticles, which generate reactive oxygen species for effective bacterial eradication when subjected to ultrasound stimulation. Through in vivo studies on rat models with infected corneal wounds, this hydrogel patch exhibits superior therapeutic efficacy compared to the current treatment. It is posited that these cornea‐inspired ultrasound‐responsive adhesive hydrogel patches represent a significant scientific advancement with high potential for clinical applications.

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Fish scale-derived scaffolds with MSCs loading for photothermal therapy of bone defect

Cited by 22 publications

References 29 publications

Materials‐Mediated In Situ Physical Cues for Bone Regeneration

Materials‐Mediated In Situ Physical Cues for Bone Regeneration

Highly Stretchable, Transparent, and Adhesive Double-Network Hydrogel Dressings Tailored with Fish Gelatin and Glycyrrhizic Acid for Wound Healing

Cornea‐Inspired Ultrasound‐Responsive Adhesive Hydrogel Patches for Keratitis Treatment

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