Fishing for New Glomerular Disease-Related Genes

Mangos, Steve; Reiser, Jochen

doi:10.1681/asn.2011090928

Journal of the American Society of Nephrology

2011

DOI: 10.1681/asn.2011090928

|View full text |Cite

Fishing for New Glomerular Disease-Related Genes

Steve Mangos

Jochen Reiser

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2012

2013

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, zebrafish being fairly easy to cultivate and showing largely conserved function of many glomerular genes is a promising in vivo model. 25 Existing zebrafish models of proteinuria rely on the injection of fluorescently labeled dextrans, which is timeconsuming and labor-intensive and cannot be used in adult zebrafish. 26 Other studies used protein detection in fish water as an indicator of proteinuria.…”

mentioning

confidence: 99%

A Photo Shoot of Proteinuria

Benzing

2012

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

mentioning

confidence: 99%

A Photo Shoot of Proteinuria

Benzing

2012

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

The podocyte slit diaphragm—from a thin grey line to a complex signalling hub

2013

View full text Add to dashboard Cite

The architectural design of our kidneys is amazingly complex, and culminates in the 3D structure of the glomerular filter. During filtration, plasma passes through a sieve consisting of a fenestrated endothelium and a broad basement membrane before it reaches the most unique part, the slit diaphragm, a specialized type of intercellular junction that connects neighbouring podocyte foot processes. When podocytes become stressed, irrespective of the causative stimulus, they undergo foot process effacement and loss of slit diaphragms--two key steps leading to proteinuria. Thus, proteinuria is the unifying denominator of a broad spectrum of podocytopathies. With the rising prevalence of chronic kidney disease and the fact that glomerular diseases account for the majority of patients with end-stage renal disease, further investigation and elucidation of this unique structure is of paramount importance. This Review recounts how perception of the slit diaphragm has changed over time as a result of intense research, from its first anatomical description as a thin intercellular connection, to an appreciation of its role as a dynamic signalling hub. These observations led to the introduction of novel concepts in podocyte biology, which could pave the way to development of highly desired, specific therapeutic strategies for glomerular diseases.

show abstract

The role of the podocyte in albumin filtration

2013

View full text Add to dashboard Cite

In the past decade, our understanding of the role of podocytes in the function of the glomerular filtration barrier, and of the role of podocyte injury in the pathogenesis of proteinuric kidney disease, has substantially increased. Landmark genetic studies identified mutations in genes expressed by podocytes as a cause of albuminuria and nephrotic syndrome, leading to breakthrough discoveries from many laboratories. These discoveries contributed to a dramatic change in our view of the glomerular filtration barrier of the kidney and of the role of podocyte injury in the development of albuminuria and progressive kidney disease. In the past several years, studies have demonstrated that podocyte injury is a major cause of marked albuminuria and nephrotic syndrome, and have confirmed that podocytes are important for the maintenance of an intact glomerular filtration barrier. An essential role of loss of these cells in the pathogenesis of glomerulosclerosis and progressive proteinuric kidney disease has also been identified. In this Review, we discuss the importance of podocytes for the maintenance of an intact glomerular filtration barrier and their role in albumin handling.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Fishing for New Glomerular Disease-Related Genes

Cited by 3 publications

References 20 publications

A Photo Shoot of Proteinuria

A Photo Shoot of Proteinuria

The podocyte slit diaphragm—from a thin grey line to a complex signalling hub

The role of the podocyte in albumin filtration

Contact Info

Product

Resources

About