Fisiopatologia e terapia do cão com sepse: revisão

Barbosa, Breno Curty; Alves, Francisco José dos Santos; Beier, Suzane; Faleiros, Rafael Resende; Freitas, Patrícia

doi:10.22256/pubvet.v10n1.13-20

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…Through this analysis, it was possible to obtain the data for statistical processing that showed a positive correlation between the number of total leukocytes and segmented neutrophil (r = 0.974) and between the number of segmented neutrophil and the number of rods (r = 0.629). In sepsis, there is an exacerbated inflammatory response of the body to an infectious stimulus, leading to the production of pro-inflammatory cytokines, tumor necrosis factor-α (TNF) and interleukin 1 (IL-1) (Barbosa et al, 2016). These cytokines induce the release of neutrophils from the medulla that are attracted to the infectious focus in an attempt to control.…”

Section: Resultsmentioning

confidence: 99%

Sepsis: Correlation of laboratory findings and animal survival rate

Oliveira¹,

Costa²,

Sepúlveda³

et al. 2023

Connecting Expertise Multidisciplinary Development for the Future

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Sepsis has become one of the biggest challenges in veterinary medicine. Sepsis is defined as an organic dysfunction resulting from an inadequate immune response to an infectious agent, threatening the life of the animal. The aim of this study was to verify the occurrence of the most frequent diseases that led animals to sepsis in the consultations performed at the Veterinary Hospital (HV) of the Universidade Vila Velha (UVV), in Vila Velha/ Espírito Santo, Brazil, observing the laboratorial alterations related to sepsis and correlating them with the life expectancy of those animals. Through a retrospective study, there was a survey of the cases seen in the period from August to December 2019. The data were tabulated and analyzed by software using a 5% significance level. The main diseases that led to sepsis were in order of frequency erliquiosis, pyometra and gastroenteritis; furthermore, it was observed that the factors influencing the survival of these animals were alteration in the values of total leukocytes (p=0.042) and the presence of azotemia (urea p <0.001 and creatinine p=0.003). This demonstrated the importance of laboratory findings in conjunction with clinical changes, allowing agility in the identification of an ongoing systemic inflammatory response syndrome (SIRS).

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Section: Resultsmentioning

confidence: 99%

Sepsis: Correlation of laboratory findings and animal survival rate

Oliveira¹,

Costa²,

Sepúlveda³

et al. 2023

Connecting Expertise Multidisciplinary Development for the Future

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“…The death of the animal probably occurred due to septic shock, although it is not very common cases of septicemia and death by S. pseudintermedius. The physiopathology of the septic shock is quite complex involving several mechanisms and intrinsic factors of the patient, as well as of the pathogen involved in the clinical picture [2,4,15]. The organic system probably suffered a dysfunction due to the action of endotoxins produced by the pathogen, which culminated with the death of the animal.…”

Section: Discussionmentioning

confidence: 99%

“…On cardiopulmonary auscultation, arrhythmia was identified. Samples of the nasal secretion and of the secretion of the abdominal pustules were collected using sterile swabs (Absorve ® ) 1 stored in Stuart medium (HiMEDIA M306 ® ) 2 and sent to the Veterinary Microbiology Laboratory of the same institution. The initial clinical suspicion was pyoderma, therefore an enrofloxacin-based broad-spectrum antibiotic was prescribed [Enrotrat tab ®3 25 mg, 5 mg/kg, SID, PO, for 5 consecutive days], and a follow-up consultation of the patient was requested for monitoring at the end of the treatment.…”

Section: Casementioning

confidence: 99%

Systemic Infection by Methicillin-resistant Staphylococcus pseudintermedius in a Bitch

Santos

Souza

Pereira

et al. 2021

Acta Scientiae. Vet.

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Background: Staphylococcus pseudintermedius is an opportunistic pathogen, belonging to the genus Staphylococcus. The methicillin-resistant Staphylococci have the mecA-gene, which confers them with the ability of becoming resistant to methicillin and multiple classes of antimicrobials, which makes the treatment of the affections caused by these specimens difficult. This work describes a case of systemic infection and death by methicillin-resistant S. pseudintermediusin a bitch.Case: A crossbred bitch (Canis lupus familiaris), was admitted to the University Veterinary Hospital of the Federal University of Western Bahia (HVU-UFOB). The main complaint reported by the owner was the presence of mammary nodules and constant nasal secretion. During the clinical examination was observed reactivity in the popliteal and left submandibular lymph nodes, pale mucous membranes, stomatitis, bilateral mucopurulent nasal secretion, abdominal pustules, serous secretion in the inguinal mammary gland and focal alopecia on the dorsum. On auscultation, was identified only arrhythmia and the other physiological parameters of the animal were within normality for the species. Samples of the nasal secretion and of the secretion from the abdominal pustules were collected, and sent to the Veterinary Microbiology Laboratory of the same institution. The samples collected were sown in 5% Blood Agar (BA), Sabouraud Agar (SAB) and MacConkey Agar (MCK), after 24 h was observed in BA the growth of macroscopically white colonies, with a humid aspect, creamy consistency, with presence of catalase and α-hemolysis. Microscopically, was observed the presence of Gram-positive cocci, suggestive of Staphylococcus sp. Microscopically, was observed the presence of Gram-positive cocci, suggestive of Staphylococcus sp. In the MALDI-TOF mass spectrometry, was identified S. pseudintermedius. Enrofloxacin [Enrotrat tab® 25 mg, 5 mg/kg, SID, PO, 5 days] was prescribed and a follow-up consultation was requested. Two weeks after leaving the University Veterinary Hospital, the animal was admitted in emergency and was submitted to the support protocol and died during the procedure. After the owner’s authorization, the anatomopathological examination was carried out, and fragments of the liver, lung and kidney were collected, in addition to sample of the liquid of the abdominal cavity for microbiological examination, and was evidenced the growth of S. pseudintermedius in all the specimens. The bacterium’s susceptibility to 19 antibiotics was tested, and a high degree of resistance was found, with sensitivity only to amoxicillin+ clavulanate (20-10 μg), chloramphenicol (30 μg) and vancomycin (30 μg). Given the detection of MRSP in Chromogenic Agar and in cefoxitin disks, all the specimens were MRSP positive.Discussion: The diagnosis based on the bacteriological culture and anatopathological findings were essential for the confirmation of the clinical presentation of septicemia. The isolation of S. pseudintermedius in all the analyzed samples, associated to the identification by MALDI-TOF Mass Spectrometry confirmed the clinical suspicion of systemic infection. Based on the result of the antibiogram and phenotypic tests, it was evidenced that all the isolates were MRSP positive, presenting multiple resistance to antibiotics, which may have interfered in the efficiency of the treatment. The results obtained in this report are worrying and signal the need for the implementation of phenotypical researches associated to anti-microbial susceptibility tests in bacteria isolated from animals attended in veterinary clinics and hospitals, in order to monitor and avoid the dissemination of pathogens with a multi-resistant profile.

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“…A sepse tem sido diagnosticada com maior frequência nos atendimentos médico-veterinários e, hoje, refere-se a uma das afecções mais recorrentes na clínica de pequenos animais 5,6 . Trata-se de uma síndrome com alta mortalidade e que pode evoluir para um quadro ainda mais grave, de choque séptico, com taxa de mortalidade maior 5 . Sendo assim, verifica-se a importância do conhecimento dessas síndromes, tanto para o seu correto diagnóstico, como para seu tratamento.…”

Section: Discussionunclassified