Microstructural data has recently become available on a single heat of 316 stainless steel irradiated in EBR-II and HFIR, over a wide range of irradiation temperature (55 to 750 C), dose (7 to 75 dpa), and helium generation rate (0.5 to 55 at. ppm He/dpa). dislocation and bubble evolution. Analysis of this data suggests a mechanism which relates to the origin and subsequent growth of precipitate associated voids.