2008
DOI: 10.1038/cr.2008.26
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FIT interacts with AtbHLH38 and AtbHLH39 in regulating iron uptake gene expression for iron homeostasis in Arabidopsis

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Cited by 539 publications
(589 citation statements)
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“…The FIT basic helix-loop-helix (bHLH) transcription factor controls the transcription of FRO2 and partly that of IRT1 in response to iron starvation in Arabidopsis (Colangelo and Guerinot, 2004;Jakoby et al, 2004;Yuan et al, 2005). FIT directly binds to FRO2 and IRT1 promoters in yeast, presumably through E-box motifs presents in both promoters (Colangelo and Guerinot, 2004;Jakoby et al, 2004;Yuan et al, 2008). Consistently, a fit loss-of-function mutant displays low FRO2 and IRT1 expression in roots (Colangelo and Guerinot, 2004;Jakoby et al, 2004;Yuan et al, 2005).…”
Section: Introductionmentioning
confidence: 70%
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“…The FIT basic helix-loop-helix (bHLH) transcription factor controls the transcription of FRO2 and partly that of IRT1 in response to iron starvation in Arabidopsis (Colangelo and Guerinot, 2004;Jakoby et al, 2004;Yuan et al, 2005). FIT directly binds to FRO2 and IRT1 promoters in yeast, presumably through E-box motifs presents in both promoters (Colangelo and Guerinot, 2004;Jakoby et al, 2004;Yuan et al, 2008). Consistently, a fit loss-of-function mutant displays low FRO2 and IRT1 expression in roots (Colangelo and Guerinot, 2004;Jakoby et al, 2004;Yuan et al, 2005).…”
Section: Introductionmentioning
confidence: 70%
“…However, constitutive expression of FIT is not sufficient to further upregulate FRO2 and IRT1 in irondeficient roots, or to induce FRO2 and IRT1 mRNA accumulation under iron-sufficient conditions (Colangelo and Guerinot, 2004;Jakoby et al, 2004;Yuan et al, 2005). FIT has been shown to heterodimerize with two other ironregulated bHLH transcription factors, bHLH38 and bHLH39, to induce expression of the iron-uptake machinery (Yuan et al, 2008). Interestingly, the master regulator FIT is itself transcriptionally regulated by iron starvation, leading to an increase in FIT mRNA level in the root epidermis (Colangelo and Guerinot, 2004;Jakoby et al, 2004).…”
Section: Introductionmentioning
confidence: 99%
“…We tested if MED25 interacted with transcription factors involved in the regulation of iron homeostasis in Arabidopsis, i.e., FIT, PYE, bHLH038, bHLH039, EIN3 and EIL1 (Colangelo and Guerinot, 2004;Yuan et al, 2008;Long et al, 2010;Lingam et al, 2011). We found that MED25 interacted directly with EIN3 and EIL1, whereas YID1/ MED16 showed no interaction (Figure 5a).…”
Section: Med25 But Not Yid1/med16 Interacts With the Transcription Famentioning
confidence: 97%
“…During iron uptake in Arabidopsis, the bHLH transcription factor FIT, the master regulator, forms heterodimers with other bHLH proteins to regulate the ferrous iron transporter IRT1 and the ferric-chelate reductase FRO2 in response to iron deficiency in plants (Robinson et al, 1999;Varotto et al, 2002;Vert et al, 2002;Connolly et al, 2003;Colangelo and Guerinot, 2004;Yuan et al, 2008;Wang et al, 2012). Our data support that FIT, rather than the interacting proteins bHLH38 or bHLLH39, plays a significant role in regulation of iron homeostasis in the yid1/med16 or med25 mutants ( Figure S6), since the induction of the two genes encoding FIT-interacting-protein, bHLH38 and bHLH39, was unaffected under iron-deficient conditions in the yid1/med16 or med25 mutants.…”
Section: Discussionmentioning
confidence: 99%
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