Fitness and physical activity in youth with type 1 diabetes mellitus in good or poor glycemic control

Nguyen, Thanh Hung; Obeid, Joyce; Walker, Rachel; Krause, Matthew P.; Hawke, Thomas J.; McAssey, Karen; Vandermeulen, J. H.; Timmons, Brian W.

doi:10.1111/pedi.12117

Cited by 58 publications

(89 citation statements)

References 43 publications

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“…The decreased exercise capacity of Akita mice observed in this study is supported by previous work in rodent models of T1D (26,27) as well as in human subjects with T1D (28)(29)(30)(31). Although the precise cause for this diminished capacity remains controversial, a number of factors are thought to contribute to this decline (30,31).…”

Section: Discussionsupporting

confidence: 87%

“…Fibers were fixed immediately after isolation (referred to as Control fibers) or placed in culture dishes with plating media (10% normal horse serum, 0.5% chick embryo extract in DMEM) overnight (18 h; referred to as Activated fibers). For all single-fiber experiments, the minimum and maximum number of fibers analyzed is provided in a range (i.e., [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] and is derived from at least three mice per experimental group.…”

Section: Single Muscle Fiber Isolationmentioning

confidence: 99%

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Decreased Satellite Cell Number and Function in Humans and Mice With Type 1 Diabetes Is the Result of Altered Notch Signaling

et al. 2016

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Type 1 diabetes (T1D) negatively influences skeletal muscle health; however, its effect on muscle satellite cells (SCs) remains largely unknown. SCs from samples from rodents (Akita) and human subjects with T1D were examined to discern differences in SC density and functionality compared with samples from their respective control subjects. Examination of the Notch pathway was undertaken to investigate its role in changes to SC functionality. Compared with controls, Akita mice demonstrated increased muscle damage after eccentric exercise along with a decline in SC density and myogenic capacity. Quantification of components of the Notch signaling pathway revealed a persistent activation of Notch signaling in Akita SCs, which could be reversed with the Notch inhibitor DAPT. Similar to Akita samples, skeletal muscle from human subjects with T1D displayed a significant reduction in SC content, and the Notch ligand, DLL1, was significantly increased compared with control subjects, supporting the dysregulated Notch pathway observed in Akita muscles. These data indicate that persistent activation in Notch signaling impairs SC functionality in the T1D muscle, resulting in a decline in SC content. Given the vital role played by the SC in muscle growth and maintenance, these findings suggest that impairments in SC capacities play a primary role in the skeletal muscle myopathy that characterizes T1D.

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Section: Discussionsupporting

confidence: 87%

Section: Single Muscle Fiber Isolationmentioning

confidence: 99%

Decreased Satellite Cell Number and Function in Humans and Mice With Type 1 Diabetes Is the Result of Altered Notch Signaling

et al. 2016

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“…The HbA 1c median difference between both groups is in accordance with the definition used by Nguyen et al, that defined controlled patients with type 1 DM has having HbA 1c below 7.5%, while uncontrolled patients had values over 9.0% [27]. One of the limitations of this study was not to have performed patient recruitment based on HbA 1c levels.…”

Section: Discussionsupporting

confidence: 57%

Type 1 diabetes does not impair the physical capacity of non-sedentary adolescents

Nascimento

Espindola

Prado

et al. 2017

Diabetol Metab Syndr

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BackgroundType 1 diabetes patients have a higher risk of developing hypoglycemia or hyperglycemia during physical activity, which may compromise their safety during exercise but results regarding the exercise capacity of patients with type 1 DM when compared to control subjects have been contradictory.AimTo evaluate if type 1 diabetes affects the capacity of adolescents to exercise.MethodsThe study enrolled 37 adolescents in stage 2–4 of the Tanner scale, aged from 10 to 14 years, 21 with type 1 diabetes and 16 without any chronic diseases. All subjects performed an incremental submaximal exercise test in a cycle ergometer. At the end of every test stage, glycemia and blood lactate levels were measured. During the test, heart rate was monitored and the Borg rating of perceived exertion (RPE) was used to assess fatigue.ResultsThe two groups displayed no significant differences in anthropometric variables. The response to exercise, as evaluated by Borg RPE (p = 0.829), maximum oxygen uptake (VO2max) (p = 0.977), heart rate (p = 0.998), maximum load (p = 0.977), absolute load at lactate threshold (p = 0.377) and relative load at lactate threshold (p = 0.282), was also similar between the control and the type 1 diabetes group. Finally, there were no significant correlations between HbA1c levels, VO2max, duration of disease and pre-test glycemia levels.ConclusionsWe detected no significant differences in lactate threshold, VO2max and heart rate during exercise between healthy adolescents and non-sedentary adolescents with type I diabetes, indicating that both groups had similar physical fitness and, therefore, that type 1 diabetes is not an obstacle for physical activity. This study was approved by the ethical committee of the Hospital Israelita Albert Einstein (Ethical Committee Number: 53638416.9.0000.0071) and free and informed consent was obtained from all participants and their legal representatives.

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“…Em relação à aptidão física, crianças que apresentavam bom controle glicêmico (HbA 1c ≤ 7,5%) não apresentaram sinais de alterações musculares. Enquanto que pacientes com mal controle glicêmico (HbA 1c ≥ 9,5%) apresentaram alterações na capacidade muscular aeróbica 45 . Tendo em vista os aspectos analisados na presente revisão, entende-se que a temática ainda necessita de investigações mais abrangentes devido à heterogeneidade dos dados.…”

Section: Tipos De Exercício Físico E Controle Metabólicounclassified

Efeitos Do Exercício Físico Sobre Diabetes Mellitus Tipo 1: Uma Revisão Sistemática De Ensaios Clínicos E Randomizados

Marçal¹,

Alexandrino²,

Cortez³

et al. 2018

J Phys Educ

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RESUMODiabetes mellitus tipo 1 (DM1) caracteriza-se como patologia crônica autoimune. Exercício físico (EF) é considerado estratégia positiva no processo terapêutico do DM1. O objetivo do estudo foi avaliar evidências científicas sobre os efeitos do EF em indivíduos com DM1. Trata-se de revisão sistemática de literatura, de estudos clínicos e randomizados. Realizou-se levantamento em periódicos indexados nas bases de dados PUBMED, SCOPUS, COCHRANE, LILACS e SCIELO. Os Descritores em Ciências da Saúde utilizados foram: diabetes mellitus, type 1 AND exercise e seus correspondentes em português e espanhol. Foram incluídos 28 artigos publicados entre os anos de 2012 e 2016. Todos os estudos abordaram a relação entre o gerenciamento da patologia e diferentes tipos, frequência, volume, duração e intensidade de exercícios. Diferentes assuntos foram abordados, como: pâncreas artificiais, dieta, suplementação, insulina e hipoglicemia. Um dos grandes desafios para assegurar boa gestão do DM1 com prática de EF são relacionados ao controle da glicemia e à hipoglicemia durante, logo depois ou tardiamente após a intervenção. Os EF aeróbicos, resistidos, pilates e intermitentes, em conjunto com dieta adequada, horários de refeições e suplementação mostraram-se eficazes no gerenciamento de diversas váriáveis metabólicas e clínicas dos pacientes com DM1. Palavras-chave: Diabetes mellitus tipo 1. Exercício. Glicemia. Insulina. ABSTRACTType 1 Diabetes mellitus (DM1) is characterized as chronic autoimmune pathology. Physical exercise (PE) is considered a positive strategy in DM1 therapy. The aim of the study was to systematize scientific evidence linking EF interventions in individuals with DM1. This is a systematic review of the literature, from clinical and randomized studies. A survey was carried out in indexed journals in the PUBMED, SCOPUS, COCHRANE, LILACS and SCIELO databases. The Descritors Health Sciences used were: diabetes mellitus, type 1 AND exercise and their correspondents in portuguese and spanish. We included 28 articles published between the years 2012 and 2016. All studies addressed the relationship between pathology management and different types, frequency, volume, duration and intensity of exercises. Different subjects were approached, such as: artificial pancreas, diet, supplementation, insulin and hypoglycemia. One of the great challenges to ensure good management of DM1 with EF practice is related to glycemic control and hypoglycemia during, shortly after or after intervention. The aerobic, resisted, pilates and intermittent PE, along with adequate diet, meal times and supplementation were effective in managing the various metabolic and clinical variables of patients with DM1. Keywords: Diabetes mellitus, type 1. Exercise. Glycemia. Insulin. IntroduçãoO Diabetes Mellitus Tipo 1 (DM1) caracteriza-se como uma patologia autoimune causada pela destruição das células beta-pancreáticas, responsáveis pela produção de insulina, esse quadro resulta na dependência, ao longo da vida, da administração do hormônio via e...

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Fitness and physical activity in youth with type 1 diabetes mellitus in good or poor glycemic control

Abstract: Children with T1DM-G did not display signs of impaired muscle function, while children with T1DM-P have signs of altered aerobic muscle capacity.

Cited by 58 publications

References 43 publications

Decreased Satellite Cell Number and Function in Humans and Mice With Type 1 Diabetes Is the Result of Altered Notch Signaling

Decreased Satellite Cell Number and Function in Humans and Mice With Type 1 Diabetes Is the Result of Altered Notch Signaling

Type 1 diabetes does not impair the physical capacity of non-sedentary adolescents

Efeitos Do Exercício Físico Sobre Diabetes Mellitus Tipo 1: Uma Revisão Sistemática De Ensaios Clínicos E Randomizados

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