Fitness Costs of Antibiotic Resistance

Alifano, Pietro

doi:10.1002/9783527659685.ch5

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2014

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“…Indeed chromosomal mutations conferring resistance to rifampin and streptomycin have been associated with functional alterations in RNA polymerase and ribosomal function respectively [22,12,16,13,5]. There is evidence that these mutations may lead to activation of (p)ppGpp‐regulated bacterial responses and have significant effects on carbon, energy and secondary metabolism, and bacterial fitness [29,27,5,1].…”

Section: Discussionmentioning

confidence: 99%

The respiratory chains of four strains of the alkaliphilic Bacillus clausii

et al. 2014

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HighlightsIt is important to understand how alkaliphilic prokaryotes thrive at high pH.An interesting issue is their ability to cope with bioenergetics at high pH.We show that four genetically similar strains adopt different biochemical behaviors.Two of the strains show a functional redundancy of the terminal part of the respiratory chain.Biochemical data correlate with the expression of cytochrome c oxidase and quinol oxidase genes (heme-copper types).

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Section: Discussionmentioning

confidence: 99%