Do crises bring people together or pull them apart? Here we examine how people’s willingness to help others and their perceived interdependence with others changed during the COVID-19 pandemic, and assess what factors are associated with any change. We collected data at 4 time points from the same cohort of 497 paid participants, starting on March 6th, before the pandemic was declared, through April 2. We found that perceived interdependence with neighbors and with humanity increased over time on multiple measures. However, regarding cooperation, agreement with the statement that helping someone in need “is the right thing to do” decreased over time (towards both a neighbor and a citizen of another country). Although the changes per time period were small for some of these effects, cumulatively they were non-trivial (ranging from a .33 to a .75 change on a 7 point likert scale). There was no change over time in participants' reported willingness to help somebody in their neighborhood (cooperation) or their feelings that when “All of humanity succeeds” they feel good (interdependence). We found reliable associations of change in cooperation and interdependence with sex, age, and pre-existing medical condition. We are collecting data on an ongoing basis which will allow us to investigate how these variables continue to change or not as the pandemic unfolds.