Five Cases of MRSA-Infected Patients with Cerebrovascular Disorder and in a Bedridden Condition, for Whom Bu-Zhong-Yi-Qi-Tang (Hochu-ekki-to) Was Useful

Itoh, Tadanobu; Itoh, Hironobu; Kikuchi, Takashi

doi:10.1142/s0192415x00000477

Cited by 8 publications

(6 citation statements)

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“…Several studies of HET on microbial infections have been investigated. In a small-scale clinical trial about MRSA infection, eradication of MRSA was successful when HET was administered to five MRSA carriers’ patients [ 12 ]. Another study showed that when HET was administered to 34 asymptomatic patients from which MRSA was isolated from urine, MRSA was not isolated from urine in 12 patients, and 10 patients decreased the bacterial volume to less than 1/100 [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hochuekkito extract (HET) has been used to treat severe infirmity such as weakness and loss of appetite of the elderly [ 11 ]. As HET is a popular alternative medicine in Japan, limited scientific evidence is available on the use of HET for the treatment of MRSA colonization [ 12 , 13 ]. Thus, the clarification of the precise mechanism of Hochuekkito efficacy against MRSA colonization has been desired.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Hochuekkito (Buzhongyiqitang) on Nasal Cavity Colonization of Methicillin-Resistant Staphylococcus aureus in Murine Model

2018

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Background: Methicillin-resistant Staphylococcus aureus (MRSA) infections are largely preceded by colonization with MRSA. Hochuekkito is the formula composing 10 herbal medicines in traditional Kampo medicine to treat infirmity and to stimulate immune functions. We evaluated the efficacy of hochuekkito extract (HET) against MRSA colonization using a nasal infection murine model. Methods: We evaluated the effects of HET as follows: (1) the growth inhibition by measuring turbidity of bacterial culture in vitro, (2) the nasal colonization of MRSA by measuring bacterial counts, and (3) the splenocyte proliferation in mice orally treated with HET by the 3H-thymidine uptake assay. Results: HET significant inhibited the growth of MRSA. The colony forming unit (CFU) in the nasal fluid of HET-treated mice was significantly lower than that of HET-untreated mice. When each single crude drug—Astragali radix, Bupleuri radix, Zingiberis rhizoma, and Cimicifugae rhizome—was removed from hochuekkito formula, the effect of the formula significantly weakened. The uptake of 3H-thymidine into murine splenocytes treated with HET was significantly higher than that from untreated mice. The effects of the modified formula described above were also significantly weaker than those of the original formula. Conclusions: Hochuekkito is effective for the treatment of MRSA nasal colonization in the murine model. We suggest HET as the therapeutic candidate for effective therapy on nasal cavity colonization of MRSA in humans.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Hochuekkito (Buzhongyiqitang) on Nasal Cavity Colonization of Methicillin-Resistant Staphylococcus aureus in Murine Model

2018

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“…In the field of skin diseases, few clinical studies have reported on the efficacy of HET. In these studies, HET is reportedly effective for methicillin‐resistant Staphylococcus aureus skin infection and atopic dermatitis …”

Section: Introductionmentioning

confidence: 99%

“…In these studies, HET is reportedly effective for methicillin-resistant Staphylococcus aureus skin infection and atopic dermatitis. 29,30 To date, there has been no clinical study on the relationship between HET and wound healing. We hypothesized that HET as an adjunctive therapy would be useful for promoting the healing of chronic wounds, as wounds are microecological environments filled with large amounts of diverse and often virulent microbes.…”

Section: Introductionmentioning

confidence: 99%

The beneficial effect of traditional Japanese herbal (Kampo) medicine, Hochu‐ekki‐to (Bu‐Zhong‐Yi‐Qi‐Tang), for patients with chronic wounds refractory to conventional therapies: A prospective, randomized trial

Akita

Namiki

Kawasaki

et al. 2019

Wound Repair Regeneration

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Hochu‐ekki‐to (HET) is a traditional Japanese herbal (Kampo) medicine for the treatment of severe weakness, loss of appetite, and indigestion in elderly patients and for the prevention of opportunistic infections. The impact of HET on patients with chronic wounds refractory to conventional therapies was investigated in a prospective, randomized trial, including 18 patients divided into medication (7.5 g oral HET per day, n = 9) and control (n = 9) groups. Wound healing during the 12‐week study period was scored based on depth, exudate, size, inflammation/infection, granulation tissue, necrotic tissue, and pocket size. At 12 weeks, wound healing progressed in all nine patients in the medication group, whereas wound healing progressed in only three patients in the control group (significant difference, p < 0.01; relative risk: 3.00). In the medication group, the total score decreased significantly at 8 weeks and later. To the best of our knowledge, this study was the first to show that HET promoted the healing of chronic wounds resistant to conventional treatments. HET may be a choice as an adjunctive therapy for chronic wounds, particularly for patients with malnutrition. This trial was registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN000031620).

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“…In experimental animal models, orally administered HOT was protective against several microbes, including Listeria monocytogenes [4,5], Helicobacter pylori [6], influenza virus [7], candida [8], and cytomegalovirus [9]. In human study, HOT was reported to be effective against MRSA infection [10]. Mice administered HOT showed enhanced production of IFN-g by CD4+ T cells and antigen-presenting capacity by tissue macrophages in experimental L. monocytogenes infection [5].…”

Section: Introductionmentioning

confidence: 99%

Maturation of monocyte-derived dendritic cells by Hochu-ekki-to, a traditional Japanese herbal medicine

Nabeshima¹,

Murata²,

Hamada³

et al. 2004

International Immunopharmacology

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Five Cases of MRSA-Infected Patients with Cerebrovascular Disorder and in a Bedridden Condition, for Whom Bu-Zhong-Yi-Qi-Tang (Hochu-ekki-to) Was Useful

Cited by 8 publications

References 0 publications

Effect of Hochuekkito (Buzhongyiqitang) on Nasal Cavity Colonization of Methicillin-Resistant Staphylococcus aureus in Murine Model

Effect of Hochuekkito (Buzhongyiqitang) on Nasal Cavity Colonization of Methicillin-Resistant Staphylococcus aureus in Murine Model

The beneficial effect of traditional Japanese herbal (Kampo) medicine, Hochu‐ekki‐to (Bu‐Zhong‐Yi‐Qi‐Tang), for patients with chronic wounds refractory to conventional therapies: A prospective, randomized trial

Maturation of monocyte-derived dendritic cells by Hochu-ekki-to, a traditional Japanese herbal medicine

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