2003
DOI: 10.1016/s0140-6736(03)14361-9
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Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial

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Cited by 631 publications
(382 citation statements)
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References 26 publications
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“…Accelerated was defined as once daily treatment of 5 weeks duration or less (2.4-2.55 Gy per fraction). Moderately accelerated fractionation schedules were defined as those of total duration greater than 5 weeks, but not more than 6 weeks (RTOG 0022 13 , DAHANCA 14 , and concomitant boost 15 schedules were included in this category). Hyperfractionated radiotherapy was defined as twice daily treatment throughout the course of radiotherapy, and was generally of 4 weeks duration (1.6 Gy per fraction).…”
Section: Methodsmentioning
confidence: 99%
“…Accelerated was defined as once daily treatment of 5 weeks duration or less (2.4-2.55 Gy per fraction). Moderately accelerated fractionation schedules were defined as those of total duration greater than 5 weeks, but not more than 6 weeks (RTOG 0022 13 , DAHANCA 14 , and concomitant boost 15 schedules were included in this category). Hyperfractionated radiotherapy was defined as twice daily treatment throughout the course of radiotherapy, and was generally of 4 weeks duration (1.6 Gy per fraction).…”
Section: Methodsmentioning
confidence: 99%
“…Shorter RT with the same total and fraction doses as those used in conventional radiotherapy improves loco-regional control and DFS. 3,7,[26][27][28][29] This conclusion is also supported by results of meta-analysis of phase III trials that concentrated mainly on accelerated hyperfractionated protocols, published by Bourhis et al 5 Reduced total dose delivered over shorter time produced results similar to conventional RT. 15 Longer than standard treatment duration has a negative impact on outcomes of radiotherapy for head and neck cancer, with loco-regional control loss of 1.2% per day or 12-14% per week.…”
Section: Discussionmentioning
confidence: 74%
“…5 If RT delivery is shortened by 1 week, outcome improves by up to 9%. 6,7 Meta-analysis of trials comparing conventional RT to hyperfractionated and/or accelerated RT for head and neck cancer found a 5-year survival benefit of 3.4% that was higher with hyperfractionated radiotherapy (8%) than with accelerated radiotherapy (1.7-2%).…”
Section: Introductionmentioning
confidence: 99%
“…The benefit of accelerated (six fractions per week) radiation has been conclusively proven in the DAHANCA Trials by Overgaard et al where 1,485 patients with head and neck carcinomas of all stages were treated with 6 versus 5 fractions of conventional radiation per week (i.e., completion of treatment was achieved in 6 vs. 7 weeks by giving an extra fraction each week) [14]. Overall, 5-year locoregional control rates improved (70 vs. 60 %; P = 0.0005) and improved disease-free survival (73 vs. 66 %; P = 0.01), but not overall survival.…”
Section: Discussionmentioning
confidence: 99%
“…Strategies to accelerate radiation can be divided into two categories: (i) pure AF regimens with reduced overall treatment time without concurrent changes in the fraction size or total dose and (ii) hybrid AF regimens with reduced overall treatment time in conjunction with changes in other parameter(s) such as the fraction size, total dose, and time distribution. Three forms of hybrid AF regimens tested in randomized clinical trials include: (a) accelerated with dose reduction, (b) accelerated with split course, and (c) accelerated with concomitant boost [14].…”
Section: Discussionmentioning
confidence: 99%