Background: Because abnormal vital signs indicate the potential for clinical deterioration, it is logical to make emergency physicians immediately aware of those patients who present with abnormal vital signs. Objectives: To determine if a clinical triggers program in the emergency department (ED) setting that utilized predetermined abnormal vital signs to activate a rapid assessment by an emergency physician-led multidisciplinary team had a measurable effect on inpatient hospital metrics. Methods: The study design was a retrospective pre and post intervention study. The intervention was the implementation of an ED clinical "triggers" program. Abnormal vital sign criteria that warranted a trigger response included: heart rate <40 beats/minute or >130 beats/minutes, respiratory rate <8 breaths/minute or >30 breaths/minute, systolic blood pressure <90 mm Hg, or oxygen saturation <90% on room air. The primary outcome investigated was the median days admitted with secondary outcomes of median days in special care unit, in-hospital 30-day mortality and proportion of patients who required an upgrade in inpatient care level. Results: There was no difference in median days admitted for inpatient care (3.8 v. 4.0 days, p = 0.21) or median days spent in a special care unit (5.0 v. 5.6 days, p = 0.42) between the groups. There was no difference in the percentage of in-hospital patient deaths (6.0% v. 5.6%, p = 0.66) or frequency of upgrade in level of care within 24 hours (4.9% v. 4.0%, p = 0.52). Conclusions: In our study, the implementation of an ED clinical triggers program did not result in a significant change in measured inpatient outcomes.