Five-membered [C,N] and [N,O] metallocyclic complexes of palladium(II) with monoalkyl [α-(4-benzeneazoanilino)-N-benzyl]phosphonates: synthesis, characterization and antitumour activity

1H, 13C and 31P NMR spectral analysis of monoalkyl (α‐anilinobenzyl)phosphonates and their dipalladium(II) metallocyclic complexes

“…Electrospray ionization mass spectrometric studies revealed the formation of binuclear -tetrakis(anilinobenzylphosphonato) dipalladium(II) complexes, Pd 2 L 4 , in which two palladium atoms are N,O-bridged by four organophosphorus ligand molecules. 12 There was no indication of the formation of polynuclear complexes. The most probable structure with a trans ligand orientation is shown in Fig.…”

“…12,14 Monobutyl ester (HL2) was prepared by acidification of the sodium salt NaL2 in a mixture of water-methanol (3 : 1) by a small excess of 5% hydrochloric acid; yield 85%, m.p. 102-103°C.…”

“…8,9 As a part of our systematic investigation of the complexing properties of various aminophosphonic acid derivatives towards palladium(II) ion, 6,7,10,11 we recently reported the synthesis and some spectroscopic and thermal properties of the [N,O] metallocyclic dipalladium(II) complexes of monoethyl (HL1) and monobutyl (HL2) esters of (˛-anilinobenzyl)phosphonic acid. 12 In these binuclear complexes, Pd 2 L 4 L D L1, L2 , four organophosphorus ligands bridge two palladium atoms by bonding through the aniline nitrogen and the deprotonated phosphonic acid oxygen. In this paper we describe a detailed 1 H, 13 C and 31 P NMR study of free monoalkyl anilinobenzylphosphonates, HL1 and HL2, and their palladium complexes in DMSO-d 6 solution.…”

“…In this paper we describe a detailed 1 H, 13 C and 31 P NMR study of free monoalkyl anilinobenzylphosphonates, HL1 and HL2, and their palladium complexes in DMSO-d 6 solution. The results obtained are compared with those obtained for the corresponding sodium salts, NaL1 and NaL2, 12 [N,O] metallocyclic complexes of monoalkyl [4-˛-(benzeneazoanilino)benzyl]phosphonates 11 and palladium(II) complexes of the corresponding dialkyl phosphonates. 13 The spectral properties of the complexes are discussed in terms of their structure-stability relationship.…”

Thermal decomposition kinetics of palladium(II) 1‐allylimidazole complexes

“…Palladium(II) halide complexes have been the subject of numerous papers because of their biological and toxicological properties as well as for their antitumor activity [1,2]. It is known that Pd(II) and Pt(II) can manifest their activities as anticancer by binding directly to DNA and deactivating it [3] (i.e.…”