Five New Furostanol Glycosides from the Fruits of Tribulus terrestris with NO Production Inhibitory Activity
Phan Van Kiem,
Nguyen Van Quoc,
Bui Huu Tai
et al.
Abstract:Eight furostanol glycosides including five undescribed compounds, named tribufurostanosides A‐E (1‐5), and three known ones (6‐8) were isolated from the fruits of Tribulus terrestris L. Their chemical structures were determined by the IR, HR‐ESI‐MS, 1D‐, and 2D‐NMR spectra. Furostanols 1‐8 significantly inhibited nitric oxide production in LPS activated RAW 264.7 cells with IC50 values ranging from 14.2 to 64.7 µM, compared to that of the positive control compound, dexamethazone (IC50 13.6 µM).
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.