Five novel dicyanidoaurate(<scp>i</scp>)-based complexes exhibiting significant biological activities: synthesis, characterization and three crystal structures

“…L = multidentate N-donor ligand). [133][134][135][136][137][138][139][140][141][142][143][144][145][146][147][148] The general connectivity is illustrated in Scheme 4.…”

Section: Purely Anionic Chain Linksmentioning

confidence: 99%

Molecular gold strings: aurophilicity, luminescence and structure–property correlations

et al. 2020

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“…The cell proliferation results disclosed that the Ag(I) molecules were remarkably more antiproliferative than cisplatin and 5FU (Fig. 6) [30][31][32][33][34]58 .…”

Section: Stability Studymentioning

confidence: 99%

Metalo components exhibiting significant anticancer and antibacterial properties: a novel sandwich-type like polymeric structure

Karadağ

Korkmaz

Aydın

et al. 2020

Sci Rep

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Four new dicyanoargentate(I)-based complexes 1-4 were synthesized from certain metal ions with a tetradentate ligand [N, N-bis (2-hydroxyethyl)-ethylenediamine; N-bishydeten] and determined by diverse procedures (elemental, thermal, FT-IR, ESI-MS for 1-3 and, magnetic susceptibility and EPR for 1, and 2) including crystal analysis of 4. The crystal method revealed that complex 4 has a sandwich-type like polymeric chemical structure with layers formed by [Cd(N-bishydeten) 2 ] 2+ cations and [Ag(CN) 2 ] − anions. The complexes were further characterized by fluorescence and UV spectroscopy to determine their physicochemical features. The complexes displayed a DNA binding activity within the same range as found for cisplatin, in addition to their strong stability in the presence of the physiological buffer system. The complexes were also investigated for pharmacological properties like interaction with DNA/Bovine serum albumin, anticancer and antibacterial activities. Physicochemical studies of DNA with the complexes suggested that the interaction mode between them are possibly both intercalative and groove binding types. These spectroscopic measurements also show that there may be a binding tendency between BSA and the complexes via hydrogen or Van der Waals bonds. The viability tests demonstrated that all the complexes exhibited antibacterial (1-4) and anticancer effects (2-4) toward ten diverse bacterial strains and three tumor cells (HT-29 colon adenocarcinoma, HeLa cervical cancer, and C6 glioma), respectively. Despite the current advances in cancer therapy, the death rate from cancer and therapeutic agents are still increasing 1. A significant number of studies have focused on the synthesis and design of a new antiproliferative agent to reduce the risk of drug resistance and cell toxicity 2-4. Some of these studies are related to metallo compounds which constitute a significant part of agents with potent pharmacological activities, and their medicinal availability has been still explored 5,6. For example, some macrocyclic polyamines containing Ni, Cu, and Ru could recognize TAR RNA molecules and cleave them, and affect the interaction of Tat-RNA 7. Mn(II) complex of 2H-5-hydroxy-1,2,5-oxadiazo[3,4-f]1,10-phenanthroline has significant antitumor activity against HL-60, KB, Hela and BGC-823 cells.

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“…Cells were incubated with tested complexes at 37°C with 5% CO2 for overnight. Cell proliferation assay was analyzed using ELISA BrdU methods as described previously [7].…”

Section: Cell Proliferation Assay (Cpa)mentioning

confidence: 99%

“…Research efforts on the development of novel anticancer agents play an important role in the current treatment process for cancer. These investigations are focused on the goal to find effective drugs without side effects or drug resistance [2][3][4][5][6][7]. It is known that the metal complexes including copper, gold, germanium, iron, that has a vital role in the normal functioning of the nervous system.…”

mentioning

confidence: 99%

Six coordination compounds: mode of cytotoxic action and biological evaluation

Aydın

Korkmaz

2016

J. Turk. Chem. Soc., Sect. A: Chem.

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anti-proliferative activity against human cervical cancer (HeLa), human colon cancer (HT29), rat glioma (C6) and African green monkey kidney (Vero) cell lines. The DNA/BSA binding affinities of these compounds were also elucidated by spectroscopic titrations, displacement experiments, and electrophoresis measurements. Studies on cancerous cells revealed that C1, C2, C4 and C6 have exhibited the significant antitumor activity and inhibited tumor progression during testing cell lines and showed high solubility in the solvent. The results of absorbance and emission spectra data have revealed that the complexes interact with the DNA via groove binding mode of interaction. Overall, these compounds have been found to demonstrate effective antiproliferative activity against the cancer cell lines, indicating that they are a potent candidate for preclinical or clinical studies.

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Five novel dicyanidoaurate(i)-based complexes exhibiting significant biological activities: synthesis, characterization and three crystal structures

Abstract: Herein the anticancer, antibacterial, and antifungal effects of the five novel dicyanidoaurate(i)-based complexes have been reported.

Cited by 21 publications

References 78 publications

Molecular gold strings: aurophilicity, luminescence and structure–property correlations

Molecular gold strings: aurophilicity, luminescence and structure–property correlations

Metalo components exhibiting significant anticancer and antibacterial properties: a novel sandwich-type like polymeric structure

Six coordination compounds: mode of cytotoxic action and biological evaluation

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