Five patients with iodine-induced hyperthyroidism

Rajatanavin, Rajata; Safran, Marjorie; Stoller, Walter A.; Mordes, John P.; Braverman, Lewis E.

doi:10.1016/0002-9343(84)90726-5

Cited by 47 publications

(21 citation statements)

References 26 publications

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“…The iodine-induced hyperthyroidism might be the result of excess iodine supply to small areas of thyroid autonomy [32]. The thyroid autoregulatory mechanisms [33] in our elderly population, especially in the low TSH values group, may be impaired following chronic overexposure to iodine. It might explain why the prevalence of subclinical hyperthyroidism was higher than that of subclinical hypothyroidism in our report.…”

Section: Discussionmentioning

confidence: 99%

Prevalence Study of Thyroid Dysfunction in the Elderly of Taiwan

Chuang

Wang

et al. 1998

Gerontology

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The present study was aimed at investigating the prevalence of thyroid dysfunction in the elderly, aged 65 years or older, in a community of southern Taiwan. By using the records of the local household registry, a sampling frame for the elderly population was constructed, and a sample of 1,400 subjects was drawn by simple random sampling. After the exclusion of nonresponse subjects, 917 subjects aged between 65 and 88 years (mean 71.9) were included in our survey. The serum thyrotropin levels of these participants were measured by monoclonal antibodies TSH immunoradiometric assays. A normal range, 0.45–4.65 µU/ml, was determined from the middle 95% of the TSH distribu- tion of 140 ‘disease-free’ subjects. By reference to the normal range, 23 (2.51%) participants had high (>4.65 µU/ml), and 41 (4.47%) had low (<0.46 µU/ml) TSH levels. The overall prevalence of thyroid dysfunction in the sample was 6.98%. Of the 23 participants with high TSH levels, 8 (34.8%) had low free T4 values (<1.21 ng/dl), so-called overt hypothyroidism, and of the 41 participants with low TSH levels, only 1 (2.4%) had high T3 values, so-called T3 thyrotoxicosis. Antithyroid antibodies were found in 56.5% of those with high TSH levels but only 12.2% of those with low TSH levels (odds ratio = 8.53, 95% confidence limits = 2.55–28.50, p < 0.001). This result indicates that autoimmune disease is still the major cause of hypothyroidism in aged people. However, the prevalence of subclinical hyperthyroidism is higher than that of subclinical hypothyroidism and it might relate to nonautoimmune factors.

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Section: Discussionmentioning

confidence: 99%

Prevalence Study of Thyroid Dysfunction in the Elderly of Taiwan

Chuang

Wang

et al. 1998

Gerontology

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“…6 New Zealand is an area of low iodine intake, 7 which may increase the risk of iodine-induced thyrotoxicosis. 8 Low iodine intake can result in reduced thyroid hormone production resulting in mild increases in Thyroid Stimulating Hormone (TSH) level. This increase in TSH can stimulate development of thyroid nodules, some of which have the ability to produce thyroid hormone independent of TSH (thyroid autonomy).…”

Section: Discussionmentioning

confidence: 99%

A cluster of thyrotoxicosis associated with consumption of a soy milk product

O’Connell¹,

Parkin

Manning

et al. 2005

Australian and New Zealand Journal of Public Health

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“…However, patients with underlying thyroid disease, such as treated or untreated Graves' disease, Hashimoto's disease, or multinodular goiter, often previously undiagnosed, were much more susceptible to the effect of iodine. When such patients consume large amounts of iodine for prolonged periods, they may develop overt and severe hypothyroidism (13,14) or paradoxically, and without explanation, thyrotoxicosis ( 15,16). Therefore, when administering iodides to large populations, one must be aware that some members are likely to develop significant thyroid dysfunction.…”

Section: Discussionmentioning

confidence: 99%