Five-Year Cumulative Incidence and Progression of Myopic Maculopathy in a German Population

Hopf, Susanne; Heidt, Franziska; Korb, Christina; Schulz, Andreas; Münzel, Thomas; Wild, Philipp S.; Beutel, Manfred E.; Schmidtmann, Irene; Lackner, Karl J.; Pfeiffer, Norbert; Schuster, Alexander K.

doi:10.1016/j.ophtha.2021.12.014

Cited by 10 publications

(30 citation statements)

References 41 publications

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“…In our study, we observed that the most common progression pattern of myopic maculopathy was the enlargement of diffuse atrophy, which is comparable with the Gutenberg Health Study (32%) and the SEED study (71.4%). However, the most common change of myopic maculopathy in Guo and colleagues’ study was category from C1 to C2 in 44 of 139 eyes (31.9%).…”

Section: Discussionsupporting

confidence: 84%

“…The 4-year incidence rate of myopic maculopathy progression in Chinese children and adolescents found in this study was 12.2%, which was lower compared with previous investigations in an older population, ranging from 19.6% to 58.6% . A recent study conducted by Guo et al that included Chinese children with high myopia aged 4 to 17 years (mean age, 11.8 [SD, 2.5] years; mean SE, −7.65 [SD, 1.86] D) with a mean follow-up of 4.9 (SD, 1.2) years reported that myopic maculopathy progressed in 52 of 274 eyes (18.9%).…”

Section: Discussioncontrasting

confidence: 63%

“…The 4-year incidence rate of myopic maculopathy progression in Chinese children and adolescents found in this study was 12.2%, which was lower compared with previous investigations in an older population, ranging from 19.6% to 58.6%. [14][15][16][17] A recent study conducted by Guo et al 11 that myopic maculopathy progressed in 52 of 274 eyes (18.9%). The difference in progression rates between Guo and colleagues' study and our study may be attributed to variations in the follow-up duration and the definition of myopic maculopathy progression.…”

Section: Discussionmentioning

confidence: 99%

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Four-Year Progression of Myopic Maculopathy in Children and Adolescents With High Myopia

Jiang,

Wang,

Xiao

et al. 2024

JAMA Ophthalmol

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ImportanceIndividuals with high myopia younger than 18 years are at relatively high risk of progressively worsening myopic maculopathy. Additional studies are needed to investigate the progression of myopic maculopathy in this age group, as well as the risk factors associated with progression.ObjectiveTo investigate the 4-year progression of myopic maculopathy in children and adolescents with high myopia, and to explore potential risk factors.Design, Setting, and ParticipantsThis hospital-based observational study with 4-year follow-up included a total of 548 high myopic eyes (spherical power −6.00 or less diopters) of 274 participants aged 7 to 17 years. Participants underwent comprehensive ophthalmic examination at baseline and 4-year follow-up. Myopic maculopathy was accessed by the International Photographic Classification and Grading System. The data analysis was performed from August 1 to 15, 2023.Main Outcomes and MeasuresThe progression of myopic maculopathy progression over 4 years and associated risk factors.ResultsThe 4-year progression of myopic maculopathy was found in 67 of 548 eyes (12.2%) of 274 participants (138 girls [50.4%] at baseline and 4-year follow-up) with 88 lesion changes, including new signs of the tessellated fundus in 16 eyes (18.2%), diffuse atrophy in 12 eyes (13.6%), patchy atrophy in 2 eyes (2.3%), lacquer cracks in 9 eyes (10.2%), and enlargement of diffuse atrophy in 49 eyes (55.7%). By multivariable analysis, worse best-corrected visual acuity (odds ratio [OR], 6.68; 95% CI, 1.15-38.99; P = .04), longer axial length (AL) (OR, 1.73; 95% CI, 1.34-2.24; P &lt; .001), faster AL elongation (OR, 302.83; 95% CI, 28.61-3205.64; P &lt; .001), and more severe myopic maculopathy (diffuse atrophy; OR, 4.52; 95% CI, 1.98-10.30; P &lt; .001 and patchy atrophy; OR, 3.82; 95% CI, 1.66-8.80; P = .002) were associated with myopic maculopathy progression.Conclusions and RelevanceIn this observational study, the progression of myopic maculopathy was observed in approximately 12% of pediatric high myopes for 4 years. The major type of progression was the enlargement of diffuse atrophy. Risk factors for myopic maculopathy progression were worse best-corrected visual acuity, longer AL, faster AL elongation, and more severe myopic maculopathy. These findings support consideration of follow-up in these individuals and trying to identify those at higher risk for progression.

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Section: Discussionsupporting

confidence: 84%

Section: Discussioncontrasting

confidence: 63%

“…The 4-year incidence rate of myopic maculopathy progression in Chinese children and adolescents found in this study was 12.2%, which was lower compared with previous investigations in an older population, ranging from 19.6% to 58.6%. [14][15][16][17] A recent study conducted by Guo et al 11 that myopic maculopathy progressed in 52 of 274 eyes (18.9%). The difference in progression rates between Guo and colleagues' study and our study may be attributed to variations in the follow-up duration and the definition of myopic maculopathy progression.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Four-Year Progression of Myopic Maculopathy in Children and Adolescents With High Myopia

Jiang,

Wang,

Xiao

et al. 2024

JAMA Ophthalmol

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“…Age was found not to be associated with the risk of progression of myopic maculopathy in high myopes (people with extreme or severe near-sightedness) aged between 35 and 74 (Hopf et al 2022) or with developing visual field damage in glaucoma suspects of African or European descent (Khachatryan et al 2015).…”

Section: Resultsmentioning

confidence: 99%

“…However, as stated in Section 2.2, the risk of visual field damage in glaucoma suspects of African descent compared to European descent did show a positive correlation with mean IOP increase. Hopf et al (2022) found that increasing IOP increased the risk of progression of myopic maculopathy in high myopes aged 35 to 74 years by 62% per mmHg at 5 years. Whilst another study found that IOP is not associated with increased risk of a change in refractive error at 5 years in adults aged 35 to 74 years (Stingl et al 2023).…”

Section: Intraocular Pressurementioning

confidence: 96%

Prognostic factors for a change in eye health or vision: A rapid review

Hammond,

Needham-Taylor,

Bromham

et al. 2024

Preprint

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The general public are advised to have regular routine eye examinations to check their vision and ocular health; however current UK guidance on how often to have eye examinations is not evidence-based and was issued in 2002.This Rapid Review aims to provide an evidence base that stakeholders can use to form updated guidance for Wales by asking the question 'What are the prognostic factors for a change in ocular status in the general population attending routine eye examinations?' The review included evidence available from January 2009 up until August 2023. Evidence was included from 2011 up until 2023. 19 studies were included: two systematic reviews; nine prospective cohort studies; three retrospective cohort studies; two longitudinal studies; two case-control studies; and one cross-sectional study were included. Research Implications and Evidence Gaps: Future research to inform appropriate eye examination intervals should be narrower in focus to ensure as much relevant and useful evidence as possible is gathered. There are large amounts of evidence on prevalence and prognostic factors for prevalent conditions, which did not meet the inclusion criteria of this rapid review which looks at incident or changing conditions. Policy and Practice Implications: Caution should be taken if using this review for decision making on appropriate eye examination intervals due to low certainty and generalisability. This review should be used to identify key prognostic factors and suggesting these for further targeted research and evidence synthesis. Economic considerations: Sight loss costs the UK economy 25 billion pounds per annum, with more than 2 million people in the UK currently living with sight loss. The economic implications of appropriate or inappropriate testing intervals for different causes of vision loss will be different. When captured at a population wide scale, the earlier detection of conditions through examination can result in significant economic savings.

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Six-month repeated irradiation of 650 nm low-level red light reduces the risk of myopia in children: a randomized controlled trial

Tian

Cao

et al. 2023

Int Ophthalmol

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Five-Year Cumulative Incidence and Progression of Myopic Maculopathy in a German Population

Cited by 10 publications

References 41 publications

Four-Year Progression of Myopic Maculopathy in Children and Adolescents With High Myopia

Four-Year Progression of Myopic Maculopathy in Children and Adolescents With High Myopia

Prognostic factors for a change in eye health or vision: A rapid review

Six-month repeated irradiation of 650 nm low-level red light reduces the risk of myopia in children: a randomized controlled trial

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