Five Year Experience in Prenatal Ultrasound Diagnosis of Esophageal Atresia in Saudi Arabia

Khorshid, Ezzeldin; Dokhan, Azza Labib; Turkistani, Adnana F; Shadi, Sulaiman M; Hassab, M Hanny

doi:10.5144/0256-4947.2003.132

Cited by 10 publications

(8 citation statements)

References 15 publications

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“…The second reason for achieving an improved survival is thanks to an ever increasing antenatal diagnosis. 5 An antenatal diagnosis results in immediate neonatal care, and pulmonary complications can also be avoided. However, there are pseudopositive cases as well as pseudonegative cases.…”

Section: Esophageal Atresiamentioning

confidence: 99%

Current progress in neonatal surgery

Taguchi

2008

Surg Today

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Neonatal surgery is the most specialized and sophisticated field of pediatric surgery. I herein review esophageal atresia, abdominal wall defects, gastrointestinal perforation, and congenital diaphragmatic hernia (CDH) as representative types of neonatal surgery. The clinical results of esophageal atresia have been considered to reflect the level of medicine of an individual country. Owing to an early diagnosis, improved operative techniques, and better perioperative management, the mortality rate has now become almost 0%. In addition, a minimally invasive thoracotomy is considered to improve long-term quality of life. The overall mortality rate of neonatal surgical disease has markedly decreased and is now less than 10%. However, abdominal wall defects, gastrointestinal perforation, and CDH still show a high mortality rate. A high incidence of chromosomal anomalies results in a poor outcome for abdominal wall defect. A gastrointestinal perforation in an infant complicated with an extremely how birth weight shows a high mortality rate. In CDH, pulmonary hypoplasia as well as pulmonary hypertension often causes an acute respiratory and circulatory deterioration after birth. Neither intensive care for pulmonary hypertension, including ECMO, nor fetal intervention has yet achieved a satisfactory outcome. Permissive hypercapnea and a delayed operation aiming at circulatory stabilization have resulted in a good survival rate. However, CDH survivors may be at risk for long-term morbidities. The method to induce pulmonary development is considered to be mandatory to achieve a good quality of life for severe CDH.

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Section: Esophageal Atresiamentioning

confidence: 99%

Current progress in neonatal surgery

Taguchi

2008

Surg Today

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“…Many studies found the incidence of congenital abnormalities to be 23/1000 live births. The incidence for birth defects of the gastrointestinal tract was 1.3 per 1000 live births, for neural tube defects (NTD) 1.9/1000 live births, and for Down’s syndrome 1.8 per 1000 live births [10-13]. …”

Section: Introductionmentioning

confidence: 99%

Risk factors and birth prevalence of birth defects and inborn errors of metabolism in Al Ahsa, Saudi Arabia

Ali¹,

Balaha²,

Moghannum³

et al. 2011

Pan Afr Med Jrnl

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BackgroundBirth defects and inborn errors of metabolism are related to variable poor perinatal and neonatal outcomes. Our aim was to explore the pattern and prevalence of birth defects and metabolic birth errors in Al-Ahsa Governorate in the Eastern Province of Saudi Arabia.MethodsThis retrospective case control study was done from April 2006 to 2009. Children with any birth defect or metabolic errors of metabolism at birth or in the neonatology section were our sample for study. Control group was randomly selected from the cases with normal live births. Blood tests were performed for children suspected to suffer from genetic blood disorders. The principal BD as per the International Classification of Diseases-10 (ICD-10) code was also noted.ResultsOut of 38001 live births, birth defects were found in 1.14% and errors of metabolism were detected in 0.17%. The most common birth defects were craniofacial malformations. The 3-methylcrotonyl-CoA carboxylase deficiency was the most common inborn errors of metabolism. Consanguinity, rural residence and prematurity were associated with significant rise in birth defects. On the other hand, consanguinity and low birth weight were associated with significant rise in metabolic errors.ConclusionFirst cousins consanguinity represented the most significant risk factor for birth defects and inborn errors of metabolism. High degree of inbreeding, consanguinity may exacerbate underlying recessive genetic risk factors.

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“…11 Another study found the incidence of congenital abnormalities to be 23/1000 live births. 12 The incidence for congenital malformation of the gastrointestinal tract was 1.3 per 1000 live births, 13 for neural tube defects (NTD) 1.9/1000 live births, 14 and for Down' s syndrome 1.8 per 1000 live births. 15 The exact antenatal prevalence of major congenital anomalies in Saudi Arabia and the prognosis of those anomalies have not been reported.…”

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Antenatal diagnosis, prevalence and outcome of major congenital anomalies in Saudi Arabia : A hospital-based study

Sallout¹,

Al-Hoshan²,

Attyyaa³

et al. 2008

Ann Saudi Med

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BACKGROUND AND OBJECTIVESThe exact antenatal prevalence of congenital anomalies in Saudi society is unknown. Early antenatal diagnosis of congenital anomalies is crucial for early counselling, intervention and possible fetal therapy. The objective of this study was to evaluate the antenatal frequency of major congenital anomalies and malformation patterns in our hospital population and to evaluate the outcome and perinatal mortality rates for major congenital anomalies.PATIENTS AND METHODSThis was a prospective study of the antenatal diagnosis of major fetal congenital anomalies conducted in the Ultrasound Department of the Women’s Specialized Hospital at King Fahad Medical City from March 2005 to February 2007. During this period, 16 639 obstetrical ultrasound examinations were performed for 7762 patients and 5379 babies delivered in our institution.RESULTSWe diagnosed 217 cases of fetal anomalies. The antenatal prevalence of congenital anomalies was 27.96 per 1000. The median maternal age at diagnosis was 27.5 years. The median gestational age at diagnosis was 31 weeks. Genitourinary and cranial anomalies were the commonest; for 186 patients delivered in our institution, the birth prevalence was 34.57 per 1000 births. The median gestational age at delivery was 38 weeks. The perinatal mortality rate was 34.9% (65/186), including all cases of intrauterine fetal and neonatal deaths.CONCLUSIONThe prevalence of major congenital anomalies in our population appears to be similar to international figures. Major congenital anomalies are a major cause of perinatal mortality.

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Five Year Experience in Prenatal Ultrasound Diagnosis of Esophageal Atresia in Saudi Arabia

Cited by 10 publications

References 15 publications

Current progress in neonatal surgery

Current progress in neonatal surgery

Risk factors and birth prevalence of birth defects and inborn errors of metabolism in Al Ahsa, Saudi Arabia

Antenatal diagnosis, prevalence and outcome of major congenital anomalies in Saudi Arabia : A hospital-based study

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