Five year experience of gallbladder polyp surveillance and cost effective analysis against new European consensus guidelines

Patel, Krashna; Dajani, Khaled; Vickramarajah, Saranya; Huguet, Emmanuel

doi:10.1016/j.hpb.2018.10.008

Cited by 22 publications

(16 citation statements)

References 34 publications

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“…16 Patel et al found that the management of gallbladder polyps based on the European consensus guidelines would be clinically cost-effective, but will significantly increase the proportion of patients requiring cholecystectomy. 15,20 Currently, no studies have been conducted to assess the impact of following these guidelines, larger-scale retrospective and prospective studies are needed to assess the benefit of managing gallbladder polyps in accordance with current guidelines.…”

Section: Gallbladder Polypsmentioning

confidence: 99%

Risk factors for the onset of gallbladder cancer: a review

Tan¹,

Deng

Gong

2021

Int Surg J

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Gallbladder cancer (GBC) is the most common malignancy of the biliary system in clinic, which has the characteristics of insidious onset and high degree of malignancy. Most patients have progressed to an advanced stage when they are diagnosed. Early identification of risk factors of the onset of gallbladder cancer and active intervention are the key to improve the rate of early diagnosis and prognosis of gallbladder cancer. At present, the risk factors related to the onset of gallbladder cancer include gallstone, gallbladder polyps, primary sclerosing cholangitis, etc. In this review, we discuss the relevant latest research on the risk factors of the onset of gallbladder cancer in order to provide clinical evidence for the prevention and early diagnosis of gallbladder cancer. The intervention, follow-up, and monitoring of risk factors should be strengthened, and the possibility of malignancy of the gallbladder should be accurately assessed in combination with factors such as age and sex. In the case of possible malignancy, prophylactic cholecystectomy should be actively performed.

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Section: Gallbladder Polypsmentioning

confidence: 99%

Risk factors for the onset of gallbladder cancer: a review

Tan¹,

Deng

Gong

2021

Int Surg J

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“…However, polyp number, shape, patient age, and sessile features also have been demonstrated as the high-risk clinical factors in previous studies [7] [8]. In addition, a considerable part of patients who underwent cholecystectomy according to the guidelines proved to be non-neoplastic polyps, and these patients bared unnecessary surgical risks and economic burdens [9]. Moreover, incidental gallbladder carcinoma in cases with polyps less than 10mm were frequently reported [10] [11].…”

Section: Introductionmentioning

confidence: 99%

A Nomogram-Based Model to Predict Neoplastic Risk For Patients With Gallbladder Polyps

Zhang

Wang

et al. 2021

Preprint

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Background: Gallbladder polyps (GBPs) assessment seeks to identify early-stage gallbladder carcinoma (GBC). Many studies have analyzed the risk factors for malignant GBPs, and we try to establish a more accurate predictive model for potential neoplastic polyps in patients with GBPs.Methods: This retrospective study developed a nomogram-based model in a training cohort of 233 GBP patients. Clinical information, ultrasonographic findings, and blood tests were retrospectively analyzed. Spearman correlation and logistic regression analysis were used to identify independent predictors and establish a nomogram model. An internal validation was conducted in 225 consecutive patients. Performance of models was evaluated through the receiver operating characteristic curve (ROC) and decision curve analysis (DCA). Results: Age, cholelithiasis, CEA, polyp size and sessile were confirmed as independent predictors for neoplastic potential of GBPs in the training group. Compared with other proposed prediction methods, the established nomogram model presented good discrimination ability in the training cohort (area under the curve [AUC]: 0.845) and the validation cohort (AUC: 0.836). DCA demonstrated the most clinical benefits can be provided by the nomogram. Conclusions: Our developed preoperative nomogram model can successfully evaluate the neoplastic potential of GBPs based on simple clinical variables, that maybe useful for clinical decision-making.

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“…7,8 A considerable number of patients who underwent cholecystectomy in accordance with GBP management guidelines were shown to have non-neoplastic polyps. 9 These patients experienced unnecessary surgical risks and economic burdens. Moreover, incidental GBC in cases with polyps <10 mm have been reported.…”

Section: Introductionmentioning

confidence: 99%

A Nomogram-based Model to Predict Neoplastic Risk for Patients with Gallbladder Polyps

Zhang

Wang

Qin

et al. 2021

J Clin Transl Hepatol

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Background and Aims: Gallbladder polyp (GBP) assessment aims to identify the early stages of gallbladder carcinoma. Many studies have analyzed the risk factors for malignant GBPs. In this retrospective study, we aimed to establish a more accurate predictive model for potential neoplastic polyps in patients with GBPs. Methods: We developed a nomogram-based model in a training cohort of 233 GBP patients. Clinical information, ultrasonographic findings, and blood test findings were analyzed. Mann-Whitney U test and multivariate logistic regression analyses were used to identify independent predictors and establish the nomogram model. An internal validation was conducted in 225 consecutive patients. Performance and clinical benefit of the model were evaluated using receiver operating characteristic curves and decision curve analysis (DCA), respectively. Results: Age, cholelithiasis, carcinoembryonic antigen, polyp size, and sessile shape were confirmed as independent predictors of GBP neoplastic potential in the training group. Compared with five other proposed prediction methods, the established nomogram model presented better discrimination of neoplastic GBPs in the training cohort (area under the curve [AUC]: 0.846) and the validation cohort (AUC: 0.835). DCA demonstrated that the greatest clinical benefit was provided by the nomogram compared with the other five methods. Conclusions: Our developed preoperative nomogram model can successfully be used to evaluate the neoplastic potential of GBPs based on simple clinical variables that maybe useful for clinical decisionmaking.

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Five year experience of gallbladder polyp surveillance and cost effective analysis against new European consensus guidelines

Cited by 22 publications

References 34 publications

Risk factors for the onset of gallbladder cancer: a review

Risk factors for the onset of gallbladder cancer: a review

A Nomogram-Based Model to Predict Neoplastic Risk For Patients With Gallbladder Polyps

A Nomogram-based Model to Predict Neoplastic Risk for Patients with Gallbladder Polyps

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