Five-year follow-up of bilateral choroidal neovascularization secondary to optic nerve head drusen treated with ranibizumab in a nine-year-old girl

Benouaich, X.; Salmon, L.; Mahieu, L.; Soler, V.

doi:10.1016/j.jfo.2015.01.026

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Recently, anti-VEGF agents have been increasingly used as the first line treatment for CNV in paediatric cases 12. Several cases have been reported in the literature describing the successful use of anti-VEGF agents including intravitreal ranibizumab and bevacizumab for the treatment of CNV associated with optic disc drusen in childhood 2–8. We report the first case in the literature of a successful treatment using the newer intravitreal agent, aflibercept.…”

Section: Discussionmentioning

confidence: 94%

“…In recent years, several case reports2–8 have been published illustrating the successful use of anti-vascular endothelial growth factor (anti-VEGF) agents, such as ranibizumab and bevacizumab, for the treatment of PPCNV secondary to optic disc drusen in children. We report the first case of successful treatment using the newer intravitreal therapy, aflibercept.…”

Section: Introductionmentioning

confidence: 99%

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Paediatric case of peripapillary choroidal neovascularisation associated with optic disc drusen treated with aflibercept

Gan

Long

2019

BMJ Case Rep

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Peripapillary choroidal neovascularisation (PPCNV) associated with optic disc drusen is a rare complication that can result in severe vision impairment in children. We report the first case of paediatric PPCNV secondary to optic disc drusen successfully treated with intravitreal aflibercept. A 6-year-old girl presented with a one week history of reduced vision in her right eye with best-corrected visual acuity of 20/500. Fundus examination revealed bilateral elevated discs with a peripapillary pigmentary lesion in the right eye. Optical coherence tomography of the right eye showed marked subfoveal fluid. Both B-scan ultrasonography and fundus autofluorescence demonstrated findings consistent with optic disc drusen. Diagnosis of PPCNV was further confirmed on fluorescein fundus angiography. The child received three intravitreal aflibercept injections with complete resolution of the subfoveal fluid. Her visual acuity improved to 20/25 with no recurrence at a 16-month follow-up. No adverse side effects were reported.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Paediatric case of peripapillary choroidal neovascularisation associated with optic disc drusen treated with aflibercept

Gan

Long

2019

BMJ Case Rep

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Néovaisseau choroïdien péripapillaire secondaire à des drusen papillaires traité par ranibizumab : résultats à 6 ans

Gambrelle

Bobo

Robinet

et al. 2021

Journal Français d'Ophtalmologie

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Four-Year Outcome of Aflibercept for Peripapillary Choroidal Neovascularization Secondary to Optic Nerve Head Drusen in a Child

Ledesma¹,

García²,

Pereda³

2020

J Pediatr Ophthalmol Strabismus

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Choroidal neovascularization is an optic nerve head drusen complication that can lead to severe vision loss. There is no prior evidence of the efficacy of intravitreal aflibercept in children in such cases. The authors report the case of a boy who was successfully treated with aflibercept with benefits lasting up to 4 years. [ J Pediatr Ophthalmol Strabismus . 2020;57:e63–e67.]

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Five-year follow-up of bilateral choroidal neovascularization secondary to optic nerve head drusen treated with ranibizumab in a nine-year-old girl

Cited by 3 publications

References 13 publications

Paediatric case of peripapillary choroidal neovascularisation associated with optic disc drusen treated with aflibercept

Paediatric case of peripapillary choroidal neovascularisation associated with optic disc drusen treated with aflibercept

Néovaisseau choroïdien péripapillaire secondaire à des drusen papillaires traité par ranibizumab : résultats à 6 ans

Four-Year Outcome of Aflibercept for Peripapillary Choroidal Neovascularization Secondary to Optic Nerve Head Drusen in a Child

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