Five-year major clinical outcomes according to severity of coronary artery spasm as assessed by intracoronary acetylcholine provocation test

Kim, Yong Hoon; Her, Ae Young; Rha, Seung Woon; Choi, Byoung Geol; Shim, Minsuk; Choi, Se Yeon; Byun, Jae Kyeong; Li, Hu; Kim, Woohyeun; Kang, Jun Hyuk; Choi, Jah Yeon; Park, Eun Jin; Park, Sung Hun; Lee, Sunki; Na, Jin Oh; Choi, Cheol Ung; Lim, Hong Euy; Kim, Eung Ju; Park, Chang Gyu; Seo, Hong Seog; Oh, Dong Joo

doi:10.1016/j.acvd.2017.05.008

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…Vasospastic angina (VA) is highly prevalent in Korea and Japan [1][2][3][4]. Although patients with VA are known to have favorable long-term prognosis [5], critical patients who present with acute coronary syndrome (ACS) and cardiac arrest have been reported [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Calcium channel blockers (CCBs) are usually prescribed to VA patients in an effort to prevent angina attacks with coronary vasospasm, and reduce the occurrence of accompanying sudden cardiovascular death and other cardiac events [4,9,10]. The first generation of CCBs like nifedipine, verapamil and diltiazem, which were introduced in 1980s, have been validated for the control of angina in patients with VA [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of calcium-channel blockers for long-term clinical outcomes in patients with vasospastic angina

Kim

Han

et al. 2021

Korean J Intern Med

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Background/Aims: Calcium channel blockers (CCBs) are the most widely prescribed medication for patients with vasospastic angina (VA). However, few studies have compared the prognosis of VA patients who are prescribed different CCBs. Methods: We enrolled 2,960 patients who received provocation test prospectively in 11 university hospitals in Korea. We divided 1,586 patients received four major CCBs into two groups: a first generation CCB (diltiazem and nifedipine) group and a second generation CCB (amlodipine and benidipine) group. Primary outcome was time to events of composite of death from any cause, acute coronary syndrome (ACS) and symptomatic arrhythmia during 3-year follow-up. We also compared the effect of each CCB on the control of angina symptoms. Results: There was no difference of the primary outcome among the two groups with a cumulative incidence rate of 5.4%, 2.9%, and a person-month incidence rate of 2.33 and 1.26, respectively (hazard ratio [HR], 0.54; 95% confidence interval [CI], 0.25 to 1.17; p = 0.120, as reference with the 1st generation CCBs). The incidence of ACS was significantly lower in 2nd generation CCBs group with a person-month incidence rate of 1.66 vs. 0.35 (HR, 0.22; 95% CI, 0.05 to 0.89; p = 0.034). Use of benidipine showed a significant better control of angina symptom compared with diltiazem for 3-years (odds ratio, 0.17; 95% CI, 0.09 to 0.32; p < 0.0001 at 3rd year). Conclusions: The first and second generation CCB groups did not differ in terms of composite outcome occurrence. However, the ACS incidence rate was significantly lower in the users of the 2nd generation CCBs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of calcium-channel blockers for long-term clinical outcomes in patients with vasospastic angina

Kim

Han

et al. 2021

Korean J Intern Med

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“…Although coronary artery spasm used to be the most common cause of MINOCA irrespective of racial, genetic, and geographic variations [2], its prevalence has tended to decrease nowadays, partly due to a reduction in smoking but, mostly, due to a decreased functional coronary reactivity assessment in busy cardiac catheterization centers. Overall, the prognosis is good once the diagnosis is made, and appropriate treatment is prescribed [3].…”

mentioning

confidence: 99%

A “NaSTy” spasm responsible for repetitive myocardial infarction with no obstructive coronary arteries and severe left ventricular dysfunction

et al. 2022

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Multivessel Coronary Function Testing Increases Diagnostic Yield in Patients With Angina and Nonobstructive Coronary Arteries

Rehan,

Wong,

Weaver

et al. 2024

JACC: Cardiovascular Interventions

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Five-year major clinical outcomes according to severity of coronary artery spasm as assessed by intracoronary acetylcholine provocation test

Cited by 4 publications

References 23 publications

Comparison of calcium-channel blockers for long-term clinical outcomes in patients with vasospastic angina

Comparison of calcium-channel blockers for long-term clinical outcomes in patients with vasospastic angina

A “NaSTy” spasm responsible for repetitive myocardial infarction with no obstructive coronary arteries and severe left ventricular dysfunction

Multivessel Coronary Function Testing Increases Diagnostic Yield in Patients With Angina and Nonobstructive Coronary Arteries

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