This month's issue of the World Journal of Surgery presents a meta-analysis and systemic review of laparoscopic anterior versus posterior fundoplication for gastro-esophageal reflux disease [1]. The authors' aim was to answer the above (very important) question, which is asked of an upper gastrointestinal surgeon countless times by his/her patients. However, although the authors have prepared a comprehensive and thorough review, their study design has not answered this question. By not addressing the anatomical differences between varying degrees of fundoplication, misleading outcomes might have been generated that will not influence current surgical practice.Why is the design of this study problematic? Similar to a meta-analysis published in Annals of Surgery in 2011 [2] by a group from the Netherlands, the authors of the current study have grouped together 90°, 120°, and 180°wraps into an 'anterior' group, and 270°and 360°wraps into a 'posterior' group. The decision to combine these quite different operations into only two groups might have falsely minimized the side effects reported in the posterior group, and falsely decreased the apparent efficacy in the anterior group, thereby leading to the conclusion that laparoscopic posterior fundoplication is the best anti-reflux operation, which may not be true.A brief review of the history of laparoscopic fundoplication illustrates the differences between wraps. Initial reports describing the technique of a laparoscopic 360°( Nissen) fundoplication emerged in 1991 [3,4]. The principles of this operation closely followed the open technique for Nissen fundoplication, which at that time included division of the short gastric vessels, posterior closure of the diaphragmatic hiatus, and creation of a 1-2 cm 360°fun-doplication, calibrated by at least a 52 Fr intra-esophageal bougie. Results were very good, with excellent reflux control. However, adverse effects including dysphagia, inability to belch, gas bloat, and excessive flatulence were not uncommon, and a flood of research ensued (which continues today) to achieve an effective anti-reflux barrier with less side effects.The posterior 270°wrap was the first partial fundoplication to emerge in the laparoscopic era, with Cuschieri et al. describing their experience with the laparoscopic Toupet (270°) fundoplication in 1993 [5]. The 270°wrap is a 'semi-fundoplication' with intra-abdominal fixation of the fundus to the diaphragm, and placement of the fundus behind the esophagus. In 2010, it was compared to the Nissen 360°fundoplication in a well-constructed metaanalysis (compiling data from seven randomized controlled trials) [6]. The total 360°wrap was found to have a significantly higher prevalence of adverse effects, with equal reflux control to the 270°wrap. It was clear from this metaanalysis that the laparoscopic 270°wrap is not equivalent to the 360°wrap, and the author's decision (in the current meta-analysis) to group both of these wraps together is questionable.Reports of a laparoscopic anterior partial fundopli...