Five‐Year Results Evaluating the Effects of Platelet‐Rich Plasma on the Healing of Intrabony Defects Treated With Enamel Matrix Derivative and Natural Bone Mineral

Dőri, Ferenc; Arweiler, Nicole Birgit; Húszár, Tamás; Gera, István; Miron, Richard J.; Sculean, Anton

doi:10.1902/jop.2013.120501

Cited by 30 publications

(31 citation statements)

References 33 publications

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“…There are several studies in which EMD has been used in combined therapy (Table 6). 71,78,109,[111][112][113][114][115][116][119][120][121][122][123][124][130][131][132][152][153][154][155] Histologic evidence of periodontal regeneration has been demonstrated when EMD is used in combination with autogenous bone, a bovine-derived natural bone mineral (NBM), † † bioactive glass, ‡ ‡ NBM + PRP, nanocrystalline hydroxyapatite (NHA), or biphasic calcium phosphate. 7,136,[156][157][158] The majority of the studies indicate no added benefits in either clinical and radiographic gains when EMD is used with the addition of graft materials.…”

Section: Periodontal Regenerative Materials and Approach Bone Replacementioning

confidence: 99%

Periodontal Regeneration – Intrabony Defects: A Systematic Review From the AAP Regeneration Workshop

Kao¹,

Nares

Reynolds

2015

Journal of Periodontology

240

228

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Background: Previous systematic reviews of periodontal regeneration with bone replacement grafts and guided tissue regeneration (GTR) were defined as state of the art for clinical periodontal regeneration as of 2002.Methods: The purpose of this systematic review is to update those consensus reports by reviewing periodontal regeneration approaches developed for the correction of intrabony defects with the focus on patient-, tooth-, and site-centered factors, surgical approaches, surgical determinants, and biologics. This review adheres to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for systematic reviews.A computerized search of the PubMed and Cochrane databases was performed to evaluate the clinically available regenerative approaches for intrabony defects. The search included screening of original reports, review articles, and reference lists of retrieved articles and hand searches of selected journals.All searches were focused on clinically available regenerative approaches with histologic evidence of periodontal regeneration in humans published in English. For topics in which the literature is lacking, non-randomized observational and experimental animal model studies were used.Therapeutic endpoints examined included changes in clinical attachment level, changes in bone level/fill, and probing depth. For purposes of analysis, change in bone fill was used as the primary outcome measure, except in cases in which this information was not available. The SORT (Strength of Recommendation Taxonomy) grading scale was used in evaluating the body of knowledge.Results: 1) Fifty-eight studies provided data on patient, tooth, and surgical-site considerations in the treatment of intrabony defects. 2) Forty-five controlled studies provided outcome analysis on the use of biologics for the treatment of intrabony defects.Conclusions: 1) Biologics (enamel matrix derivative and recombinant human platelet-derived growth factor-BB plus b-tricalcium phosphate) are generally comparable with demineralized freezedried bone allograft and GTR and superior to open flap debridement procedures in improving clinical parameters in the treatment of intrabony defects. 2) Histologic evidence of regeneration has been demonstrated with laser therapy; however, data are limited on clinical predictability and effectiveness. 3) Clinical outcomes appear most appreciably influenced by patient behaviors and surgical approach rather than by tooth and defect characteristics. 4) Long-term studies indicate that improvements in clinical parameters are maintainable up to 10 years, even in severely compromised teeth, consistent with a favorable/good long-term prognosis. J Periodontol 2015;86(Suppl.):S77-S104.

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Section: Periodontal Regenerative Materials and Approach Bone Replacementioning

confidence: 99%

Periodontal Regeneration – Intrabony Defects: A Systematic Review From the AAP Regeneration Workshop

Kao¹,

Nares

Reynolds

2015

Journal of Periodontology

240

228

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“…Acceleration of hard tissue maturation and block graft procedures also produces a quantity of immature hard osteoid tissue within lesser time than the conventional time, hence improves primary stability for implant along with 20% greater trabecular bone density and 85% greater proportion of mature haversian system in the initial months supported by no evidence of active resorption and remodeling, indicating a level of stable maturity. 8,32 The main purpose of PRP is to reduce the use of autologous bone graft collected from the patients sites and reducing the mucosal incisions 32 Though Ozdemir, Raghoebar, Schaaf et al conveyed no beneficial effects of PRP with grafts in their literature [33][34][35][36][37][38][39][40][41][42][43] (Table 2).…”

Section: Marx Et Al Supported By Garg Et Al 2004mentioning

confidence: 99%

The Clinical Application Of Platelet Concentrates: A Systematic Meta-analysis

Gada¹

2015

International Journal of Prosthodontics and Restorative Dentistry

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Background: Autologous plasma rich in platelets is derived blood product whose uses in dentistry dates back to the 1990s and it has been gaining popularity ever since.Aim: A systematic review of the available literature to determine the efficacy, safety and success of platelet concentrates in physiological systems as well as describing its vigilant use. Study design and methods:A Medline search with keywords 'platelet rich plasma dental' further filtered using Boolean operators (AND, Or, NOt) and combination of specific keywords as follows: 'platelet rich fibrin', 'platelet rich plasma regenerative', 'platelet rich plasma periodontal', 'platelet rich plasma extraction' with a custom range of 10 years was performed, which yielded 88 results out of which 32 were selected based on the inclusion criteria.Results: Significantly, successful outcomes have been witnessed in the field of osteoregeneration though it has been evidenced that adequate platelet rich plasma (PrP) additives are essential to bear a therapeutic potential. Favoring blood cell adhesion on the root surface optimizing periodontal healing, PrP has also shown positive effect on gingival repair; though controversial facts have also been reported. In the scope of implant dentistry, PrP has also reported greater implant-bone contact when used in both gel or liquid form. Emerging as a possible pulp capping agent along with properties of decreased chances root growth, PrP has successfully completed apexogenesis in cases of pulpotomy.research has shown that although clinical results from the comparison of PrP alone vs PrP and resorbable membrane or various graft materials has shown a varied results, additional research in the field is needed. Conclusion:Platelet rich plasma has shown promising results in the field of regenerative dentistry, with high success rate in implantology, periodontology and oral surgery. Because of conflicting success rates reported in literature further research is warrented. Clinical implication:Platelet rich fibrin has displayed various features of rapid clinical healing, excellent bone density, less surgical time, less resorption during healing and decreased postoperative pain, as compared to guided bone regeneration procedures. Platelet rich plasma has also shown a myriad of applications ranging from hard tissue regeneration to soft tissue management, stretching across to the field of pediatric dentistry and endodontics.

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“…Nonetheless, the limited effectiveness of formation of periodontal soft and hard tissues still leaves room for additional improvement. 5,[9][10][11] Potential shortcomings include inadequate properties of currently used absorbable membranes, such as limited rigidity and low osteoconductivity, and occasional membrane exposure. 12 These aspects require additional improvement to better use barrier materials.…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, additional regenerative strategies, such as the use of biomaterials and growth factors, have been combined with GTR to promote periodontal tissue restoration. Nonetheless, the limited effectiveness of formation of periodontal soft and hard tissues still leaves room for additional improvement 5,9‐11 . Potential shortcomings include inadequate properties of currently used absorbable membranes, such as limited rigidity and low osteoconductivity, and occasional membrane exposure 12 .…”

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confidence: 99%

Demineralized Dentin as a Semi‐Rigid Barrier for Guiding Periodontal Tissue Regeneration

Zou

Chen

et al. 2015

Journal of Periodontology

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Five‐Year Results Evaluating the Effects of Platelet‐Rich Plasma on the Healing of Intrabony Defects Treated With Enamel Matrix Derivative and Natural Bone Mineral

Abstract: Within their limits, the present results indicate that: 1) the clinical outcomes obtained with both treatments can be maintained up to a period of 5 years; and 2) the use of PRP does not appear to improve the results obtained with EMD + NBM.

Cited by 30 publications

References 33 publications

Periodontal Regeneration – Intrabony Defects: A Systematic Review From the AAP Regeneration Workshop

Periodontal Regeneration – Intrabony Defects: A Systematic Review From the AAP Regeneration Workshop

The Clinical Application Of Platelet Concentrates: A Systematic Meta-analysis

Demineralized Dentin as a Semi‐Rigid Barrier for Guiding Periodontal Tissue Regeneration

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