Five-year results of vocal fold augmentation using autologous fat or calcium hydroxylapatite

Zeleník, Karol; Formánek, Martin; Walderová, Radana; Formánková, Debora; Komínek, Pavel

doi:10.1007/s00405-020-06479-6

Cited by 16 publications

(10 citation statements)

References 16 publications

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“…We read with interest the well-written recent article by Zelenik et al reporting on the long-term results of vocal fold augmentation using autologous fat or calcium hydroxylapatite [1]. This is a great effort by experienced laryngologists.…”

Section: Dear Editorsmentioning

confidence: 99%

In response to “Five-year results of vocal fold augmentation using autologous fat or calcium hydroxylapatite”

Karkos

Koskinas

Stavrakas

et al. 2021

Eur Arch Otorhinolaryngol

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Section: Dear Editorsmentioning

confidence: 99%

In response to “Five-year results of vocal fold augmentation using autologous fat or calcium hydroxylapatite”

Karkos

Koskinas

Stavrakas

et al. 2021

Eur Arch Otorhinolaryngol

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“…Intracordal drug injection is an intermediate approach between conservative treatment and surgery. Intracordal injection of several materials, including atelocollagen, 7 autologous fat, 8 and calcium hydroxylapatite, 9 is currently used to treat dysphonia. Steroid injection is widely used to treat benign vocal fold lesions, including vocal fold scarring 10–13 .…”

Section: Introductionmentioning

confidence: 99%

Intracordal injection therapy for vocal fold scarring: Steroid versus basic fibroblast growth factor

Nozawa

Takahashi

Kanazawa

et al. 2022

Laryngoscope Investig Oto

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Objectives Vocal fold scarring is caused by replacement of vocal fold mucosa with fibrous tissue due to repeated inflammation or trauma. It can lead to severe dysphonia. It is currently treated conservatively and with phonosurgery and intracordal injections. Intracordal injection of steroid or basic fibroblast growth factor (bFGF) has been recently found to be useful for treating vocal fold scarring that does not respond to voice therapy. Methods This retrospective study involved the administration of steroid injection and bFGF injection bilaterally under local anesthesia in 16 patients each. Laboratory measurements of voice parameters were performed before and 3–6 months after injection. Results In the steroid injection group, the Voice Handicap Index (VHI) score significantly improved from 57.1 to 40.5, total Grade, Roughness, Breathiness, Asthenia, Strain (tGRBAS) score significantly improved from 4.2 to 2.6, and mean speech fundamental frequency (SFF) increased from 192.5 to 211.4 dB, but there was no improvement in maximum phonation time (MPT) and mean airflow rate (MFR). In the bFGF injection group, significant improvements in the VHI score (from 53.3 to 35.7), MPT (from 16.9 to 21.8 s) and MFR (from 314.6 to 210.5 ml/s) were seen; however, the tGRBAS score did not improve. In addition, the SFF significantly decreased from 178.1 to 160.5 Hz. Conclusion These results suggest that both steroid and bFGF injections are effective for treating vocal fold scarring, with steroids improving voice quality and bFGF improving glottic closure, thereby contributing to improvements in VHI scores. Level of Evidence 4.

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“…As presbylaryngis is a form of glottic insufficiency, it can be treated with methods to increase glottic contact, such as voice therapy, injection laryngoplasty, and medialization thyroplasty [ 7 – 9 ]. In addition to medialization by injection of space-occupying materials (e.g., calcium hydroxyapatite), the use of various substances, such as growth factors, platelet-rich plasma, and stem cells, has been examined to restore the sophisticated and unique structure of vocal-fold mucosa and muscles both in vivo and in clinical trials [ 10 – 12 ]. Regeneration of laryngeal tissues and restoration of intrinsic laryngeal functions are challenging problems that have yet to be addressed by existing injectable materials.…”

Section: Introductionmentioning

confidence: 99%

Injection laryngoplasty of human adipose-derived stem cell spheroids with hyaluronic acid-based hydrogel improves the morphological and functional characteristics of geriatric larynx

Lee

Choi

et al. 2022

Biomater Res

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Aim As the geriatric population increased, the need of treatment for laryngeal atrophy and dysfunction increased. This study was performed to evaluate the effects of injection of human adipose-derived stem cell (hASC) spheroid-loaded catechol-conjugated hyaluronic acid (HA-CA) hydrogel on therapeutic rejuvenation of the geriatric larynx. Methods Stem cell spheroids with hyaluronic acid-based hydrogel were injected into the laryngeal muscles of 18-month-old Sprague–Dawley rats. The effects of hASC spheroids were examined in the following four groups: SHAM, injected with PBS; GEL, injected with HA-CA hydrogel; MONO, injected with single hASCs in HA-CA hydrogel; and SP, injected with hASCs spheroids in HA-CA hydrogel. The rejuvenation efficacy in geriatric laryngeal muscle tissues at 12 weeks postinjection was evaluated and compared by histology, immunofluorescence staining, and functionality analysis. Results Total myofiber cross-sectional area and myofiber number/density, evaluated by detection of myosin heavy chain with antibodies against laminin and fast myosin heavy chain, were significantly higher in the SP group than in the other groups. The lamina propria of the larynx was evaluated by alcian blue staining, which showed that the HA was increased significantly in the SP group compared to the other groups. In functional analysis, the glottal gap area was significantly reduced in the SP group compared to the other groups. The phase difference in the vocal fold during vibration was also smaller in the SP group than in the other groups, but the difference did not reach statistical significance. Conclusion Injection of hASC spheroids with hyaluronic acid-based hydrogel improves the morphological and functional characteristics of geriatric larynx. Graphical abstract

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Five-year results of vocal fold augmentation using autologous fat or calcium hydroxylapatite

Cited by 16 publications

References 16 publications

In response to “Five-year results of vocal fold augmentation using autologous fat or calcium hydroxylapatite”

In response to “Five-year results of vocal fold augmentation using autologous fat or calcium hydroxylapatite”

Intracordal injection therapy for vocal fold scarring: Steroid versus basic fibroblast growth factor

Injection laryngoplasty of human adipose-derived stem cell spheroids with hyaluronic acid-based hydrogel improves the morphological and functional characteristics of geriatric larynx

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