Five‐year stability of clinical attachment after regenerative treatment of infrabony defects compared to controls

Abstract

Aim:To evaluate the stability of attachment achieved in infrabony defects by regenerative treatment over 60 ± 12 months compared to control teeth. Methods:Patients treated regeneratively in at least one infrabony defect between 2004 and 2010 were screened for this retrospective cohort study. Complete examinations available for baseline, 12 and 60 ± 12 months after surgery, and a respective control tooth without treatment, provided eligibility for analysis. Results: Twenty-seven patients (age 58 ± 11.7 years; 12 females, five smokers) were included, each contributing one infrabony defect and one control tooth. Regenerative therapy resulted in significant attachment gain (2.7 ± 1.6 mm; p < 0.001) after 1 and (3.0 ± 2.2 mm; p < 0.001) 5 years. Control teeth were stable (vertical probing attachment level [PAL-V] change: 1 year: 0 ± 0.8 mm; 5 years: −0.2 ± 1.2 mm). The study did not detect any significant change of PAL-V from 1 to 5 years after surgery for regenerative (−0.3 ± 2.4 mm) and control teeth (−0.2 ± 1.4 mm). Multivariate analysis associated smoking and generalized recurrence of periodontitis (amount of sites with PPD > 5 mm) with attachment loss. Conclusions: PAL-V achieved by regenerative therapy in infrabony defects is as stable over 5 years as periodontally reduced but gingivally healthy or gingivitis sites. Smoking and periodontitis recurrence are associated with attachment loss. K E Y W O R D S guided tissue regeneration, operative, periodontal attachment loss, periodontitis, surgical procedures | 651 ABDUL RAHMAN et AL.

Application of Chitosan in Bone and Dental Engineering

“…However, such a treatment strategy is associated mainly to wound repair, characterized by a long junctional epithelium. In most severe cases (probing pocket depth (PPD) > 5 mm), non-surgical treatment alone could be insufficient in emphasizing the need of adjuvant therapy [72,73]. Therefore, the use of local delivery of active drugs or compounds has been suggested to target inflammation and infection, and in promoting tissue regeneration [74,75,76,77].…”

Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration

“…In general, reducing the inflammation is a key to control the infection for periodontal therapy, but traditional mechanical treatments like scaling and root planin are closely connected with the wound repair. In addition, non-surgical treatment alone is insufficient for adjuvant therapy ( Abdul Rahman et al, 2019 ; Harmouche et al, 2019 ). Therefore, use of local delivery of active drugs has been utilized as an effective strategy to address the inflammation and promote tissue repair ( Morand et al, 2017 ; Batool et al, 2018 ; Petit et al, 2019 ).…”

Layered scaffolds in periodontal regeneration

“…Moreover, continuous periodontitis can dramatically reduce the regeneration capacity of PDL and CM and also, affect the regeneration of the whole multiple periodontal tissues. 8 In addition, the clinical outcomes of those techniques are variable and uncertain. 6 …”