Five Year Study of Cardiovascular Risk Factors in Japanese People: Implications Concerning New Onset of Metabolic Syndrome

Suzuki, Akiko; Kosuge, Keiichiro; Nanyu, Osamu; Watanabe, Hiroshi; Watanabe, Tôru; Usuda, Yoshimaru; Sasaki, Shigeru; Aizawa, Yoshifusa

doi:10.2169/internalmedicine.49.2689

Cited by 11 publications

(11 citation statements)

References 25 publications

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“…In our previous study [19], new onset of MetS was determined as new clustering of 3 or more CVD risk factors during the followup of 5 years in the general population. In this study, we studied the reversal rate from clustering of CVD risk factors during the same followup period.…”

Section: Introductionmentioning

confidence: 99%

Reversal Rate of Clustering of Cardiovascular Disease Risk Factors of Metabolic Syndrome in the General Population: The Niigata Preventive Medicine Study

et al. 2010

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The reversal rate from clustering of cardiovascular disease (CVD) risk factors—components of the metabolic syndrome (MetS) is not known. Methods and Results. Among 35,534 subjects who received the annual health examinations at the NiigataHealth Foundation (Niigata, Japan), 4,911 subjects had clustering of 3 or more of the following CVD risk factors: (1) body mass index (BMI) ≥25 Kg/m2, (2) blood pressure ≥130 mm Hg in systolic and/or ≥85 mm Hg in diastolic, (3) triglycerides ≥150 mg/dL, (4) high-density lipoprotein cholesterol ≤40 mg/dL in men, ≤50 mg/dL in women, and (5) fasting blood glucose ≥100 mg/dL. After 5 years 1,929 subjects had a reversal of clustering (39.4%). A reversal occurred more often in males. The subjects with a reversal of clustering had milder level of each risk factor and a smaller number of risk factors, while BMI was associated with the least chance of a reversal. Conclusion. We concluded that a reversal of clustering CVD risk factors is possible in 4/10 subjects over a 5-year period by habitual or medical interventions. Gender and each CVD risk factor affected the reversal rate adversely, and BMI was associated with the least chance of a reversal.

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Section: Introductionmentioning

confidence: 99%

Reversal Rate of Clustering of Cardiovascular Disease Risk Factors of Metabolic Syndrome in the General Population: The Niigata Preventive Medicine Study

et al. 2010

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“…AH was repeatedly reported to be a strong individual risk factor for both IHD and IS [11][12][13][14][15] . However, AH seems to be more strongly related to IHD than to IS.…”

Section: Discussionmentioning

confidence: 99%

“…Risk factors for atherosclerosis which plays a crucial role in the development of both IHD and IS, have already had been well-studied [11][12][13][14][15] . However, IHD and IS represent different nosological entities.…”

Section: Discussionmentioning

confidence: 99%

“…Atherosclerosis plays a major role in IHD as well as IS development, but in IS stroke the situation is far more complex and other etiologies play a significant role too (e.g. cardio-embolism, small vessel disease, thrombophilia) [11][12][13][14][15] .…”

Section: Discussionmentioning

confidence: 99%

“…It is not clear to date, why IHD is present only in some IS patients and not in others 9,10 . IHD and IS traditional risk factors have been well-studied and documented individually on large prospective cohorts [11][12][13][14][15] and there are new studies appearing. In the majority of cases, these risk factors are same for both entities.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors associated with ischemic heart disease occurence in acute ischemic stroke patients

Kováčik¹,

Madarasz²,

Král³

et al. 2013

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aims. At specific time periods following ischemic stroke (IS), acute coronary syndrome as ischemic heart disease (IHD) represents a higher risk of death than IS. Not all IS patients can undergo specific examination for IHD detection. The aim of this study was to assess exclusive risk factors (RFs) associated with IHD occurrence in IS patients. Knowledge of these RFs should help in stratifying IS patients for IHD detection. Materials and methods. This was a hospital-based, retrospective, single centre study. The sample consisted of 192 consecutive IS patients, divided into two subgroups -Subgroup 1 (54 patients without IHD; 55.6% males; 63.1 ± 11.8 years) and Subgroup 2 (138 patients with IHD; 39.1% males; 76.3 ± 9.6 years). The following factors were identified: age; sex; presence of arterial hypertension, atrial fibrillation, diabetes mellitus; plasma levels of total cholesterol, triglycerides, low-density cholesterol, high-density cholesterol; body mass index; presence of carotid plaques. Logistic regression analysis was used for statistical evaluation. Results. Of all identified risk factors only age (OR=1.109; 95% CI: 1.069 -1.150, P=0.001) and the presence of arterial hypertension (OR=6.298; 95% CI: 2.215 -17.905, P=0.003) were exclusively and significantly associated with the presence of IHD in IS patients. Conclusions. Age and arterial hypertension may be exclusive risk factors associated with IHD in IS patients.

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Citrin Deficiency

Song¹,

Yazaki²,

Saheki³

2019

Human Pathobiochemistry

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Five Year Study of Cardiovascular Risk Factors in Japanese People: Implications Concerning New Onset of Metabolic Syndrome

Abstract: Background

Cited by 11 publications

References 25 publications

Reversal Rate of Clustering of Cardiovascular Disease Risk Factors of Metabolic Syndrome in the General Population: The Niigata Preventive Medicine Study

Reversal Rate of Clustering of Cardiovascular Disease Risk Factors of Metabolic Syndrome in the General Population: The Niigata Preventive Medicine Study

Risk factors associated with ischemic heart disease occurence in acute ischemic stroke patients

Citrin Deficiency

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